Gene Ontology

Gene Info

• Species: Mouse (Mus musculus)
• GeneID: 16367
• Symbol: Irs1
• Description: insulin receptor substrate 1

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
16367	GO:0002053	IGI	acts_upstream_of_or_within	positive regulation of mesenchymal cell proliferation	17662267	Process
16367	GO:0008286	IDA	acts_upstream_of_or_within	insulin receptor signaling pathway	9813005	Process
16367	GO:0008286	IDA	involved_in	insulin receptor signaling pathway	7542745	Process
16367	GO:0008286	IGI	involved_in	insulin receptor signaling pathway	9038347	Process
16367	GO:0008286	IMP	involved_in	insulin receptor signaling pathway	7526222,8649419,33839150	Process
16367	GO:0010468	IMP	acts_upstream_of_or_within	regulation of gene expression	11375348	Process
16367	GO:0010631	IGI	acts_upstream_of	epithelial cell migration	17662267	Process
16367	GO:0010634	IGI	acts_upstream_of_or_within	positive regulation of epithelial cell migration	17662267	Process
16367	GO:0016042	IMP	acts_upstream_of_or_within	lipid catabolic process	11375348	Process
16367	GO:0016477	IGI	acts_upstream_of	cell migration	17662267	Process
16367	GO:0030073	IMP	NOT acts_upstream_of_or_within	insulin secretion	9062343	Process
16367	GO:0030879	IGI	acts_upstream_of_or_within	mammary gland development	17662267	Process
16367	GO:0032869	IDA	acts_upstream_of_or_within	cellular response to insulin stimulus	11375348	Process
16367	GO:0034504	IDA	acts_upstream_of_or_within	protein localization to nucleus	19952108	Process
16367	GO:0034504	IMP	acts_upstream_of_or_within	protein localization to nucleus	19952108	Process
16367	GO:0043491	IGI	acts_upstream_of_or_within	protein kinase B signaling	15249583	Process
16367	GO:0043552	IMP	acts_upstream_of_or_within	positive regulation of phosphatidylinositol 3-kinase activity	11375348	Process
16367	GO:0048009	IDA	involved_in	insulin-like growth factor receptor signaling pathway	12483226	Process
16367	GO:0048009	IGI	involved_in	insulin-like growth factor receptor signaling pathway	7969452	Process
16367	GO:0048009	IMP	involved_in	insulin-like growth factor receptor signaling pathway	7969452	Process
16367	GO:0061903	IMP	acts_upstream_of_or_within	positive regulation of 1-phosphatidylinositol-3-kinase activity	11375348	Process
16367	GO:0071398	IMP	involved_in	cellular response to fatty acid	21986524	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
16367	GO:0005068	IDA	enables	transmembrane receptor protein tyrosine kinase adaptor activity	8649419,12483226	Function
16367	GO:0005068	IMP	enables	transmembrane receptor protein tyrosine kinase adaptor activity	11784871	Function
16367	GO:0005515	IPI	enables	protein binding	9813005,17965023,18059474,18296638,19952108,20144759,20804756,.....	Function
16367	GO:0019901	IDA	enables	protein kinase binding	14733908	Function
16367	GO:0030674	IDA	enables	protein-macromolecule adaptor activity	7542745,9399964	Function
16367	GO:0030674	IGI	enables	protein-macromolecule adaptor activity	9038347	Function
16367	GO:0043548	IDA	enables	phosphatidylinositol 3-kinase binding	11375348	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
16367	GO:0005634	IDA	located_in	nucleus	12878164	Component
16367	GO:0005737	IDA	located_in	cytoplasm	12878164	Component
16367	GO:0005886	IDA	located_in	plasma membrane	11375348	Component
16367	GO:0036064	IDA	located_in	ciliary basal body	19596798	Component