Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 16409
  • Symbol: Itgam
  • Description: integrin alpha M

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16409 GO:0001774 IMP involved_in microglial cell activation 18981141 Process
16409 GO:0001781 IMP involved_in neutrophil apoptotic process 8986723 Process
16409 GO:0002523 IMP acts_upstream_of_or_within leukocyte migration involved in inflammatory response 23550035 Process
16409 GO:0006898 IMP involved_in receptor-mediated endocytosis 20199584,22438044 Process
16409 GO:0006909 IMP involved_in phagocytosis 8986723 Process
16409 GO:0006911 IMP involved_in phagocytosis, engulfment 20199584,22438044,22632727 Process
16409 GO:0007155 IGI acts_upstream_of_or_within cell adhesion 19342649 Process
16409 GO:0007155 IMP acts_upstream_of_or_within cell adhesion 10528208 Process
16409 GO:0007159 IMP acts_upstream_of_or_within leukocyte cell-cell adhesion 8562500 Process
16409 GO:0014005 IDA acts_upstream_of_or_within microglia development 20578039 Process
16409 GO:0030593 IMP acts_upstream_of_or_within neutrophil chemotaxis 10528208 Process
16409 GO:0030900 IDA involved_in forebrain development 18685038 Process
16409 GO:0032930 IDA involved_in positive regulation of superoxide anion generation 18685038 Process
16409 GO:0032930 IMP involved_in positive regulation of superoxide anion generation 18981141 Process
16409 GO:0045123 IMP acts_upstream_of_or_within cellular extravasation 10528208 Process
16409 GO:0045963 IDA involved_in negative regulation of dopamine metabolic process 18981141 Process
16409 GO:0050798 IMP acts_upstream_of_or_within activated T cell proliferation 15210787 Process
16409 GO:0060376 IMP involved_in positive regulation of mast cell differentiation 9862668 Process
16409 GO:0061756 IMP involved_in leukocyte adhesion to vascular endothelial cell 8986723 Process
16409 GO:0090314 IMP involved_in positive regulation of protein targeting to membrane 18981141 Process
16409 GO:0097190 IDA involved_in apoptotic signaling pathway 18685038 Process
16409 GO:0097242 IGI involved_in amyloid-beta clearance 20199584 Process
16409 GO:0097242 IMP involved_in amyloid-beta clearance 22438044 Process
16409 GO:0098609 IGI acts_upstream_of_or_within cell-cell adhesion 16093349 Process
16409 GO:0110090 IDA involved_in positive regulation of hippocampal neuron apoptotic process 18685038 Process
16409 GO:0150062 IMP involved_in complement-mediated synapse pruning 22632727 Process
16409 GO:0150064 IMP involved_in vertebrate eye-specific patterning 22632727 Process
16409 GO:1904151 IMP involved_in positive regulation of microglial cell mediated cytotoxicity 18685038 Process
16409 GO:1905114 IMP involved_in cell surface receptor signaling pathway involved in cell-cell signaling 22632727 Process
16409 GO:2000363 IMP involved_in positive regulation of prostaglandin-E synthase activity 18981141 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16409 GO:0001846 IDA enables opsonin binding 12163569 Function
16409 GO:0001846 IMP enables opsonin binding 12163569 Function
16409 GO:0001851 IGI enables complement component C3b binding 20199584 Function
16409 GO:0005515 IPI enables protein binding 28228282 Function
16409 GO:0008201 IDA enables heparin binding 8043862 Function
16409 GO:0038024 IGI enables cargo receptor activity 22438044 Function
16409 GO:0038024 IMP contributes_to cargo receptor activity 20199584 Function
16409 GO:0043395 IDA enables heparan sulfate proteoglycan binding 8043862 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16409 GO:0005634 IDA located_in nucleus 15138196 Component
16409 GO:0005886 IDA located_in plasma membrane 8986723,9862668 Component
16409 GO:0009897 IDA located_in external side of plasma membrane 8043862,8552190,8557754,8769481,8788039,10848813,12163569,1460..... Component
16409 GO:0009986 IDA located_in cell surface 9324354 Component
16409 GO:0016020 IDA located_in membrane 12529407 Component
16409 GO:0034688 IMP part_of integrin alphaM-beta2 complex 20199584 Component