Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 16438
  • Symbol: Itpr1
  • Description: inositol 1,4,5-trisphosphate receptor 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16438 GO:0000902 IMP involved_in cell morphogenesis 32675284 Process
16438 GO:0001666 IDA involved_in response to hypoxia 19120137 Process
16438 GO:0006816 IDA acts_upstream_of_or_within calcium ion transport 16014380 Process
16438 GO:0007200 IMP involved_in phospholipase C-activating G protein-coupled receptor signaling pathway 26075576,31664108 Process
16438 GO:0007207 IGI involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 10570150 Process
16438 GO:0009791 IMP acts_upstream_of_or_within post-embryonic development 17590087 Process
16438 GO:0019722 EXP acts_upstream_of_or_within calcium-mediated signaling 11117745 Process
16438 GO:0032024 IGI involved_in positive regulation of insulin secretion 10570150 Process
16438 GO:0032024 IMP involved_in positive regulation of insulin secretion 26075576,31664108 Process
16438 GO:0032469 IGI acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis 15613488 Process
16438 GO:0042045 IDA involved_in epithelial fluid transport 23542070 Process
16438 GO:0048016 EXP acts_upstream_of_or_within inositol phosphate-mediated signaling 11117745 Process
16438 GO:0050882 IMP acts_upstream_of_or_within voluntary musculoskeletal movement 17590087 Process
16438 GO:0051209 EXP acts_upstream_of_or_within release of sequestered calcium ion into cytosol 11117745 Process
16438 GO:0051209 IMP involved_in release of sequestered calcium ion into cytosol 19752026 Process
16438 GO:0070059 IMP involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 19752026 Process
16438 GO:0099105 IGI involved_in ion channel modulating, G protein-coupled receptor signaling pathway 10570150 Process
16438 GO:0099105 IMP involved_in ion channel modulating, G protein-coupled receptor signaling pathway 31664108 Process
16438 GO:0099566 EXP acts_upstream_of_or_within regulation of postsynaptic cytosolic calcium ion concentration 11117745 Process
16438 GO:1990806 IGI involved_in ligand-gated ion channel signaling pathway 10570150 Process
16438 GO:1990806 IMP involved_in ligand-gated ion channel signaling pathway 26075576,31664108 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16438 GO:0005220 IDA enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 2554142,17327232,20813840 Function
16438 GO:0005220 IGI enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 10570150 Function
16438 GO:0005515 IPI enables protein binding 10051594,12444087,12611586,12617961,15483626,15579147,15613488..... Function
16438 GO:0015278 IDA enables calcium-release channel activity 20813840 Function
16438 GO:0019904 IPI enables protein domain specific binding 32675284 Function
16438 GO:0035091 IDA enables phosphatidylinositol binding 8663526,17327232,20813840 Function
16438 GO:0098695 EXP enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels 11117745 Function
16438 GO:0098695 IDA enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels 11117745 Function
16438 GO:0098695 IMP enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels 11117745 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16438 GO:0005635 IDA located_in nuclear envelope 16014380 Component
16438 GO:0005637 IDA located_in nuclear inner membrane 16014380 Component
16438 GO:0005730 IDA located_in nucleolus 16014380 Component
16438 GO:0005737 IDA located_in cytoplasm 9858485 Component
16438 GO:0005783 IDA located_in endoplasmic reticulum 24374158,25368151 Component
16438 GO:0005789 IDA located_in endoplasmic reticulum membrane 15613488 Component
16438 GO:0005955 IDA part_of calcineurin complex 12617961 Component
16438 GO:0014069 IDA located_in postsynaptic density 15579147 Component
16438 GO:0016529 IDA located_in sarcoplasmic reticulum 16014380 Component
16438 GO:0032991 IPI part_of protein-containing complex 17416589 Component
16438 GO:0045202 IPI is_active_in synapse 32675284 Component
16438 GO:0098685 EXP is_active_in Schaffer collateral - CA1 synapse 11117745 Component
16438 GO:0098685 IDA is_active_in Schaffer collateral - CA1 synapse 11117745 Component
16438 GO:0098685 IMP is_active_in Schaffer collateral - CA1 synapse 11117745 Component