Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 16452
  • Symbol: Jak2
  • Description: Janus kinase 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16452 GO:0001774 IGI involved_in microglial cell activation 26227742 Process
16452 GO:0006366 IGI acts_upstream_of transcription by RNA polymerase II 20530874 Process
16452 GO:0006919 IDA involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process 12426001 Process
16452 GO:0007165 IMP involved_in signal transduction 9590173,9590174 Process
16452 GO:0007167 IDA acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway 8022486 Process
16452 GO:0007259 IDA acts_upstream_of_or_within receptor signaling pathway via JAK-STAT 12147240,21606371 Process
16452 GO:0007259 IGI involved_in receptor signaling pathway via JAK-STAT 26227742 Process
16452 GO:0007259 IMP acts_upstream_of_or_within receptor signaling pathway via JAK-STAT 11821424,15354294 Process
16452 GO:0007260 IDA acts_upstream_of_or_within tyrosine phosphorylation of STAT protein 12388746 Process
16452 GO:0007260 IMP acts_upstream_of_or_within tyrosine phosphorylation of STAT protein 11821424 Process
16452 GO:0008285 IMP acts_upstream_of_or_within negative regulation of cell population proliferation 11821424 Process
16452 GO:0014068 IMP involved_in positive regulation of phosphatidylinositol 3-kinase signaling 7782332 Process
16452 GO:0018108 IDA acts_upstream_of_or_within peptidyl-tyrosine phosphorylation 10872802 Process
16452 GO:0019221 IMP involved_in cytokine-mediated signaling pathway 9590173,9590174 Process
16452 GO:0030099 IMP acts_upstream_of_or_within myeloid cell differentiation 15354294 Process
16452 GO:0030154 IMP acts_upstream_of_or_within cell differentiation 11821424 Process
16452 GO:0030218 IMP involved_in erythrocyte differentiation 9590173,9590174 Process
16452 GO:0032496 IDA involved_in response to lipopolysaccharide 11536325 Process
16452 GO:0032731 IGI involved_in positive regulation of interleukin-1 beta production 26227742 Process
16452 GO:0032760 IDA involved_in positive regulation of tumor necrosis factor production 12426001 Process
16452 GO:0032760 IGI involved_in positive regulation of tumor necrosis factor production 26227742 Process
16452 GO:0034050 IDA acts_upstream_of_or_within programmed cell death induced by symbiont 12426001 Process
16452 GO:0035166 IMP involved_in post-embryonic hemopoiesis 23544085 Process
16452 GO:0035556 IDA acts_upstream_of_or_within intracellular signal transduction 8022486 Process
16452 GO:0036016 IDA acts_upstream_of_or_within cellular response to interleukin-3 8378315 Process
16452 GO:0042102 IDA involved_in positive regulation of T cell proliferation 11114383 Process
16452 GO:0042531 IDA involved_in positive regulation of tyrosine phosphorylation of STAT protein 8923468,15156153 Process
16452 GO:0042976 IDA involved_in activation of Janus kinase activity 20304997 Process
16452 GO:0043066 IDA acts_upstream_of_or_within negative regulation of apoptotic process 12147240 Process
16452 GO:0043392 IDA acts_upstream_of_or_within negative regulation of DNA binding 12388746 Process
16452 GO:0045348 IGI involved_in positive regulation of MHC class II biosynthetic process 26227742 Process
16452 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 20530874 Process
16452 GO:0046777 IDA involved_in protein autophosphorylation 20304997 Process
16452 GO:0050731 IMP involved_in positive regulation of peptidyl-tyrosine phosphorylation 7782332 Process
16452 GO:0051770 IDA involved_in positive regulation of nitric-oxide synthase biosynthetic process 10600756,12426001 Process
16452 GO:0051770 IGI involved_in positive regulation of nitric-oxide synthase biosynthetic process 26227742 Process
16452 GO:0060397 IDA involved_in growth hormone receptor signaling pathway via JAK-STAT 8923468 Process
16452 GO:0060397 IMP involved_in growth hormone receptor signaling pathway via JAK-STAT 20304997 Process
16452 GO:0060399 IMP involved_in positive regulation of growth hormone receptor signaling pathway 17761766 Process
16452 GO:0061180 IMP acts_upstream_of_or_within mammary gland epithelium development 12040017 Process
16452 GO:0071222 IDA acts_upstream_of_or_within cellular response to lipopolysaccharide 21606371 Process
16452 GO:0071549 IDA acts_upstream_of_or_within cellular response to dexamethasone stimulus 21606371 Process
16452 GO:0097191 IDA acts_upstream_of_or_within extrinsic apoptotic signaling pathway 12426001 Process
16452 GO:0097296 IDA involved_in activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 12426001 Process
16452 GO:0120162 IMP involved_in positive regulation of cold-induced thermogenesis 26515423 Process
16452 GO:2000273 IGI involved_in positive regulation of signaling receptor activity 26227742 Process
16452 GO:2001235 IMP acts_upstream_of_or_within positive regulation of apoptotic signaling pathway 15012602 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16452 GO:0004713 EXP enables protein tyrosine kinase activity 7527668,7538110,7961995,8400282,9111318,10822380 Function
16452 GO:0004713 IDA enables protein tyrosine kinase activity 8378315,10872802,12147240,20304997 Function
16452 GO:0004713 IMP enables protein tyrosine kinase activity 15012602 Function
16452 GO:0005143 IPI enables interleukin-12 receptor binding 11489994 Function
16452 GO:0005515 IPI enables protein binding 7535773,8943354,10872802,12023369,15121872,15156153,16824542,1..... Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16452 GO:0005634 IDA located_in nucleus 15156153 Component
16452 GO:0005901 IDA located_in caveola 12388746 Component
16452 GO:0045121 IDA located_in membrane raft 12388746 Component