Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 1654
  • Symbol: DDX3X
  • Description: DEAD-box helicase 3 X-linked

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1654 GO:0003677 IDA enables DNA binding 21589879 Function
1654 GO:0003678 IDA enables DNA helicase activity 21589879 Function
1654 GO:0003723 HDA enables RNA binding 22658674,22681889 Function
1654 GO:0003723 IDA enables RNA binding 21589879 Function
1654 GO:0003724 IDA enables RNA helicase activity 21589879,31575075 Function
1654 GO:0003729 IDA enables mRNA binding 29062139 Function
1654 GO:0003924 IDA enables GTPase activity 10074132 Function
1654 GO:0005515 IPI enables protein binding 10074132,10329544,10336476,17855521,18596238,18628297,18636090..... Function
1654 GO:0008134 IDA enables transcription factor binding 16818630 Function
1654 GO:0008143 IDA enables poly(A) binding 18596238 Function
1654 GO:0008190 IDA enables eukaryotic initiation factor 4E binding 17667941 Function
1654 GO:0016887 IDA enables ATP hydrolysis activity 10074132,21589879 Function
1654 GO:0017111 IDA enables ribonucleoside triphosphate phosphatase activity 10074132 Function
1654 GO:0031369 IDA enables translation initiation factor binding 22323517,22872150 Function
1654 GO:0033592 IDA enables RNA strand annealing activity 27546789 Function
1654 GO:0035591 IDA enables signaling adaptor activity 23478265 Function
1654 GO:0035613 IDA enables RNA stem-loop binding 22872150 Function
1654 GO:0043015 IDA enables gamma-tubulin binding 28842590 Function
1654 GO:0043024 IDA enables ribosomal small subunit binding 22323517 Function
1654 GO:0043273 IDA enables CTPase activity 10074132 Function
1654 GO:0043539 IDA enables protein serine/threonine kinase activator activity 23413191 Function
1654 GO:0045296 HDA enables cadherin binding 25468996 Function
1654 GO:0048027 IDA enables mRNA 5'-UTR binding 22872150 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1654 GO:0005634 IDA located_in nucleus 10074132,10329544,29899501,30131165,31575075 Component
1654 GO:0005654 IDA located_in nucleoplasm Component
1654 GO:0005737 IDA is_active_in cytoplasm 18636090 Component
1654 GO:0005737 IDA located_in cytoplasm 10329544,24965446,27736973,28733330,30131165,30341167,31575075..... Component
1654 GO:0005737 IMP located_in cytoplasm 10074132,26100019 Component
1654 GO:0005813 IDA located_in centrosome 28842590 Component
1654 GO:0005829 IDA located_in cytosol Component
1654 GO:0005886 IDA located_in plasma membrane 29899501 Component
1654 GO:0010494 IDA located_in cytoplasmic stress granule 18596238,21883093 Component
1654 GO:0031252 IDA located_in cell leading edge 28733330 Component
1654 GO:0070062 HDA located_in extracellular exosome 19056867,19199708,20458337 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1654 GO:0006413 IMP involved_in translational initiation 26100019 Process
1654 GO:0007059 IMP involved_in chromosome segregation 21730191 Process
1654 GO:0008625 IMP involved_in extrinsic apoptotic signaling pathway via death domain receptors 18846110 Process
1654 GO:0009615 IDA involved_in response to virus 18636090 Process
1654 GO:0010501 IDA involved_in RNA secondary structure unwinding 22872150 Process
1654 GO:0010628 IDA involved_in positive regulation of gene expression 10074132 Process
1654 GO:0016055 IMP involved_in Wnt signaling pathway 26235985 Process
1654 GO:0017148 IMP involved_in negative regulation of translation 17667941 Process
1654 GO:0030307 IMP involved_in positive regulation of cell growth 18628297,20837705 Process
1654 GO:0030308 IDA involved_in negative regulation of cell growth 16818630 Process
1654 GO:0031333 IDA involved_in negative regulation of protein-containing complex assembly 17667941 Process
1654 GO:0031954 IDA involved_in positive regulation of protein autophosphorylation 30341167 Process
1654 GO:0032481 IDA involved_in positive regulation of type I interferon production 23478265 Process
1654 GO:0032727 IDA involved_in positive regulation of interferon-alpha production 30341167 Process
1654 GO:0032728 IDA involved_in positive regulation of interferon-beta production 27980081,31575075 Process
1654 GO:0034063 IDA involved_in stress granule assembly 21883093 Process
1654 GO:0034157 IDA involved_in positive regulation of toll-like receptor 7 signaling pathway 30341167 Process
1654 GO:0034161 IDA involved_in positive regulation of toll-like receptor 8 signaling pathway 30341167 Process
1654 GO:0035556 IDA involved_in intracellular signal transduction 18636090 Process
1654 GO:0036493 IMP involved_in positive regulation of translation in response to endoplasmic reticulum stress 29062139 Process
1654 GO:0042256 IMP involved_in cytosolic ribosome assembly 22323517 Process
1654 GO:0043065 IMP involved_in positive regulation of apoptotic process 16301996 Process
1654 GO:0043066 IMP involved_in negative regulation of apoptotic process 18846110 Process
1654 GO:0043154 IMP involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 18846110 Process
1654 GO:0043280 IMP involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 16301996 Process
1654 GO:0045070 IMP involved_in positive regulation of viral genome replication 20862261 Process
1654 GO:0045087 IMP involved_in innate immune response 18583960 Process
1654 GO:0045727 IDA involved_in positive regulation of translation 18596238,22872150 Process
1654 GO:0045727 IMP involved_in positive regulation of translation 28842590 Process
1654 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 16818630,18636090,28128295 Process
1654 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 18583960,28842590 Process
1654 GO:0045948 IMP involved_in positive regulation of translational initiation 20837705 Process
1654 GO:0055088 IMP involved_in lipid homeostasis 28128295 Process
1654 GO:0071243 IDA involved_in cellular response to arsenic-containing substance 21883093 Process
1654 GO:0071470 IDA involved_in cellular response to osmotic stress 21883093 Process
1654 GO:0071902 IDA involved_in positive regulation of protein serine/threonine kinase activity 23413191 Process
1654 GO:0090263 IMP involved_in positive regulation of canonical Wnt signaling pathway 23413191 Process
1654 GO:0097193 IMP involved_in intrinsic apoptotic signaling pathway 16301996 Process
1654 GO:0098586 IDA involved_in cellular response to virus 31575075 Process
1654 GO:1900087 IMP involved_in positive regulation of G1/S transition of mitotic cell cycle 20837705 Process
1654 GO:1901223 IMP involved_in negative regulation of NIK/NF-kappaB signaling 27736973 Process
1654 GO:1901224 IMP involved_in positive regulation of NIK/NF-kappaB signaling 30341167 Process
1654 GO:1901985 IMP involved_in positive regulation of protein acetylation 28128295 Process
1654 GO:1902042 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 18846110 Process
1654 GO:1902523 IDA involved_in positive regulation of protein K63-linked ubiquitination 27980081 Process
1654 GO:1903608 IMP involved_in protein localization to cytoplasmic stress granule 24965446 Process
1654 GO:2001243 IMP involved_in negative regulation of intrinsic apoptotic signaling pathway 21883093 Process