Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 16846
  • Symbol: Lep
  • Description: leptin

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16846 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 21234744 Process
16846 GO:0001932 IDA involved_in regulation of protein phosphorylation 21234744 Process
16846 GO:0002021 IGI acts_upstream_of_or_within response to dietary excess 12177191 Process
16846 GO:0002021 IMP acts_upstream_of_or_within response to dietary excess 16141392 Process
16846 GO:0006006 IMP acts_upstream_of_or_within glucose metabolic process 12540600 Process
16846 GO:0006111 IMP acts_upstream_of_or_within regulation of gluconeogenesis 16513828 Process
16846 GO:0006629 IMP acts_upstream_of_or_within lipid metabolic process 12815040 Process
16846 GO:0006635 IGI acts_upstream_of_or_within fatty acid beta-oxidation 22958918 Process
16846 GO:0006909 IDA involved_in phagocytosis 9438411 Process
16846 GO:0007260 IDA involved_in tyrosine phosphorylation of STAT protein 21234744 Process
16846 GO:0008203 IGI acts_upstream_of_or_within cholesterol metabolic process 15995171 Process
16846 GO:0008206 IDA acts_upstream_of_or_within bile acid metabolic process 12114517 Process
16846 GO:0008340 IGI acts_upstream_of_or_within determination of adult lifespan 28069950 Process
16846 GO:0008343 IDA involved_in adult feeding behavior 9590691 Process
16846 GO:0010507 IMP involved_in negative regulation of autophagy 25060689 Process
16846 GO:0014068 IDA involved_in positive regulation of phosphatidylinositol 3-kinase signaling 20620997 Process
16846 GO:0019222 IMP acts_upstream_of_or_within regulation of metabolic process 12925742 Process
16846 GO:0019953 IMP involved_in sexual reproduction 8589726 Process
16846 GO:0021954 IMP acts_upstream_of_or_within central nervous system neuron development 10592285 Process
16846 GO:0030073 IGI acts_upstream_of_or_within insulin secretion 16141392 Process
16846 GO:0030217 IMP involved_in T cell differentiation 9732873 Process
16846 GO:0030300 IDA acts_upstream_of_or_within regulation of intestinal cholesterol absorption 12114517 Process
16846 GO:0032099 IDA involved_in negative regulation of appetite 9590691 Process
16846 GO:0032735 IDA involved_in positive regulation of interleukin-12 production 9438411 Process
16846 GO:0032755 IDA involved_in positive regulation of interleukin-6 production 9438411 Process
16846 GO:0032760 IDA involved_in positive regulation of tumor necrosis factor production 9438411 Process
16846 GO:0032868 IMP acts_upstream_of_or_within response to insulin 16141392 Process
16846 GO:0032869 IDA acts_upstream_of_or_within cellular response to insulin stimulus 29519872 Process
16846 GO:0033210 IDA involved_in leptin-mediated signaling pathway 16825198 Process
16846 GO:0035904 IMP acts_upstream_of_or_within aorta development 23413430 Process
16846 GO:0042307 IDA involved_in positive regulation of protein import into nucleus 21234744 Process
16846 GO:0042445 IMP acts_upstream_of_or_within hormone metabolic process 16513828 Process
16846 GO:0042593 IGI acts_upstream_of_or_within glucose homeostasis 22958918 Process
16846 GO:0042755 IGI acts_upstream_of_or_within eating behavior 10802666 Process
16846 GO:0043410 IDA involved_in positive regulation of MAPK cascade 16825198 Process
16846 GO:0045598 IGI acts_upstream_of_or_within regulation of fat cell differentiation 22927639 Process
16846 GO:0045639 IDA acts_upstream_of_or_within positive regulation of myeloid cell differentiation Process
16846 GO:0046427 IDA involved_in positive regulation of receptor signaling pathway via JAK-STAT 16825198,21234744 Process
16846 GO:0046850 IMP involved_in regulation of bone remodeling 10660043 Process
16846 GO:0046890 IGI acts_upstream_of_or_within regulation of lipid biosynthetic process 28069950 Process
16846 GO:0050790 IMP acts_upstream_of_or_within regulation of catalytic activity 23413430 Process
16846 GO:0050796 IMP acts_upstream_of_or_within regulation of insulin secretion 16513828 Process
16846 GO:0050810 IMP acts_upstream_of_or_within regulation of steroid biosynthetic process 16513828 Process
16846 GO:0050999 IDA involved_in regulation of nitric-oxide synthase activity 15899045 Process
16846 GO:0051541 IMP acts_upstream_of_or_within elastin metabolic process 23413430 Process
16846 GO:0051726 IDA involved_in regulation of cell cycle 16825198 Process
16846 GO:0051897 IDA involved_in positive regulation of protein kinase B signaling 16825198 Process
16846 GO:0060612 IGI acts_upstream_of_or_within adipose tissue development 10742101 Process
16846 GO:0070093 IDA involved_in negative regulation of glucagon secretion 21234744 Process
16846 GO:0090335 IDA involved_in regulation of brown fat cell differentiation 20620997 Process
16846 GO:0098868 IMP involved_in bone growth 10660043 Process
16846 GO:0120162 IMP involved_in positive regulation of cold-induced thermogenesis 27986616 Process
16846 GO:1900180 IMP acts_upstream_of_or_within regulation of protein localization to nucleus 20541607 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16846 GO:0003677 IDA enables DNA binding 29519872 Function
16846 GO:0005515 IPI enables protein binding 24882746 Function
16846 GO:0008083 IDA enables growth factor activity Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16846 GO:0005615 IDA located_in extracellular space 9590691,11387233,12540600,17693256,20952387 Component
16846 GO:0005737 IDA located_in cytoplasm 11387233 Component