Gene Ontology

Gene Info

• Species: Rat (Rattus norvegicus)
• GeneID: 170851
• Symbol: Map2k1
• Description: mitogen activated protein kinase kinase 1

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
170851	GO:0003056	IMP	involved_in	regulation of vascular associated smooth muscle contraction	10198244	Process
170851	GO:0006468	IDA	involved_in	protein phosphorylation	7565670,7611406,8393135	Process
170851	GO:0006979	IDA	involved_in	response to oxidative stress	16481589	Process
170851	GO:0010508	IDA	involved_in	positive regulation of autophagy	26581593	Process
170851	GO:0010628	IGI	involved_in	positive regulation of gene expression	15459207	Process
170851	GO:0010628	IMP	involved_in	positive regulation of gene expression	15459207	Process
170851	GO:0010629	IGI	involved_in	negative regulation of gene expression	28947594	Process
170851	GO:0030182	IMP	involved_in	neuron differentiation	17202850	Process
170851	GO:0030335	IMP	involved_in	positive regulation of cell migration	17183546	Process
170851	GO:0032402	IDA	involved_in	melanosome transport	15753041	Process
170851	GO:0032968	IMP	involved_in	positive regulation of transcription elongation by RNA polymerase II	18086894	Process
170851	GO:0034111	IMP	involved_in	negative regulation of homotypic cell-cell adhesion	17183546	Process
170851	GO:0043410	IDA	involved_in	positive regulation of MAPK cascade	7935430	Process
170851	GO:0043547	IMP	involved_in	positive regulation of GTPase activity	17183546	Process
170851	GO:0045933	IGI	involved_in	positive regulation of muscle contraction	15459207	Process
170851	GO:0045933	IMP	involved_in	positive regulation of muscle contraction	15459207	Process
170851	GO:0046579	IMP	acts_upstream_of_or_within	positive regulation of Ras protein signal transduction	19029245	Process
170851	GO:0047496	IDA	involved_in	vesicle transport along microtubule	15753041	Process
170851	GO:0048313	IMP	involved_in	Golgi inheritance	9458043	Process
170851	GO:0048678	IMP	involved_in	response to axon injury	15737734	Process
170851	GO:0048812	IMP	involved_in	neuron projection morphogenesis	17202850	Process
170851	GO:0051384	IDA	involved_in	response to glucocorticoid	11872750	Process
170851	GO:0070328	IDA	involved_in	triglyceride homeostasis	26581593	Process
170851	GO:0070372	IDA	involved_in	regulation of ERK1 and ERK2 cascade	26581593	Process
170851	GO:0098696	EXP	involved_in	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	12202034	Process
170851	GO:0098696	IDA	involved_in	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	12202034	Process
170851	GO:1903298	IGI	involved_in	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	15459207	Process
170851	GO:1903298	IMP	involved_in	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	15459207	Process
170851	GO:2001171	IGI	involved_in	positive regulation of ATP biosynthetic process	15459207	Process
170851	GO:2001171	IMP	involved_in	positive regulation of ATP biosynthetic process	15459207	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
170851	GO:0004708	IDA	enables	MAP kinase kinase activity	7611406,7624324,7935430,8393135	Function
170851	GO:0005515	IPI	enables	protein binding	16272159	Function
170851	GO:0005524	IDA	enables	ATP binding	7611406	Function
170851	GO:0019901	IPI	enables	protein kinase binding	15917294	Function
170851	GO:0031267	IPI	enables	small GTPase binding	7935430	Function
170851	GO:0031435	IDA	enables	mitogen-activated protein kinase kinase kinase binding	7565670	Function
170851	GO:0031435	IPI	enables	mitogen-activated protein kinase kinase kinase binding	16006144	Function
170851	GO:0044877	IPI	enables	protein-containing complex binding	15917294	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
170851	GO:0005874	IDA	colocalizes_with	microtubule	10465442	Component
170851	GO:0005938	IDA	located_in	cell cortex	16272159	Component
170851	GO:0014069	IDA	is_active_in	postsynaptic density	7478291	Component
170851	GO:0030424	IDA	located_in	axon	9714150	Component
170851	GO:0030425	IDA	located_in	dendrite	10465442	Component
170851	GO:0032839	IDA	located_in	dendrite cytoplasm	9714150	Component
170851	GO:0043204	IDA	located_in	perikaryon	9714150,10465442	Component
170851	GO:0048471	IDA	located_in	perinuclear region of cytoplasm	12876277	Component
170851	GO:0098978	EXP	is_active_in	glutamatergic synapse	12202034	Component
170851	GO:0098978	IDA	is_active_in	glutamatergic synapse	12202034	Component