Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 17128
  • Symbol: Smad4
  • Description: SMAD family member 4

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
17128 GO:0000122 IMP acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II 24739304 Process
17128 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 16151019,16330325,18539898 Process
17128 GO:0001541 IGI acts_upstream_of_or_within ovarian follicle development 24739304 Process
17128 GO:0001541 IMP acts_upstream_of_or_within ovarian follicle development 24739304 Process
17128 GO:0001658 IGI acts_upstream_of_or_within branching involved in ureteric bud morphogenesis 15925496 Process
17128 GO:0001701 IMP acts_upstream_of_or_within in utero embryonic development 9420335 Process
17128 GO:0001702 IMP acts_upstream_of_or_within gastrulation with mouth forming second 15215210 Process
17128 GO:0001822 IMP acts_upstream_of_or_within kidney development 15342483 Process
17128 GO:0003148 IGI involved_in outflow tract septum morphogenesis 17628518 Process
17128 GO:0003190 IGI involved_in atrioventricular valve formation 21330551 Process
17128 GO:0003198 IMP involved_in epithelial to mesenchymal transition involved in endocardial cushion formation 21330551 Process
17128 GO:0003220 IMP involved_in left ventricular cardiac muscle tissue morphogenesis 16151019 Process
17128 GO:0003251 IMP involved_in positive regulation of cell proliferation involved in heart valve morphogenesis 21330551 Process
17128 GO:0003279 IGI involved_in cardiac septum development 21330551 Process
17128 GO:0003360 IMP acts_upstream_of_or_within brainstem development 21300867 Process
17128 GO:0006357 IDA acts_upstream_of_or_within regulation of transcription by RNA polymerase II 12270938 Process
17128 GO:0006366 IMP acts_upstream_of transcription by RNA polymerase II 18692037 Process
17128 GO:0006879 IMP involved_in intracellular iron ion homeostasis 16330325 Process
17128 GO:0007179 IGI acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway 18212064 Process
17128 GO:0007179 IMP involved_in transforming growth factor beta receptor signaling pathway 16330325 Process
17128 GO:0007283 IMP acts_upstream_of_or_within spermatogenesis 24739304 Process
17128 GO:0007338 IGI acts_upstream_of_or_within single fertilization 24739304 Process
17128 GO:0007369 IMP acts_upstream_of_or_within gastrulation 9420335 Process
17128 GO:0007411 IMP acts_upstream_of_or_within axon guidance 21300867 Process
17128 GO:0007492 IMP acts_upstream_of_or_within endoderm development 9420335,26494787 Process
17128 GO:0007498 IMP acts_upstream_of_or_within mesoderm development 9420335 Process
17128 GO:0008283 IGI acts_upstream_of cell population proliferation 9506519,10626800,11197776,15925496 Process
17128 GO:0008283 IMP acts_upstream_of_or_within cell population proliferation 9420335 Process
17128 GO:0008285 IGI acts_upstream_of_or_within negative regulation of cell population proliferation 9506519,10626800,11197776,15925496 Process
17128 GO:0008584 IMP acts_upstream_of_or_within male gonad development 24739304 Process
17128 GO:0008585 IGI acts_upstream_of_or_within female gonad development 24739304 Process
17128 GO:0009653 IMP acts_upstream_of_or_within anatomical structure morphogenesis 26494787 Process
17128 GO:0009952 IMP acts_upstream_of_or_within anterior/posterior pattern specification 15215210 Process
17128 GO:0010614 IMP involved_in negative regulation of cardiac muscle hypertrophy 16151019 Process
17128 GO:0010718 IMP involved_in positive regulation of epithelial to mesenchymal transition 14691138 Process
17128 GO:0010862 IMP involved_in positive regulation of pathway-restricted SMAD protein phosphorylation 14691138 Process
17128 GO:0014033 IMP acts_upstream_of_or_within neural crest cell differentiation 19793887 Process
17128 GO:0030154 IMP acts_upstream_of_or_within cell differentiation 26494787 Process
17128 GO:0030509 IMP involved_in BMP signaling pathway 16330325 Process
17128 GO:0032525 IMP acts_upstream_of_or_within somite rostral/caudal axis specification 9420335 Process
17128 GO:0033686 IGI acts_upstream_of_or_within positive regulation of luteinizing hormone secretion 24739304 Process
17128 GO:0033686 IMP acts_upstream_of_or_within positive regulation of luteinizing hormone secretion 24739304 Process
17128 GO:0036302 IGI involved_in atrioventricular canal development 21330551 Process
17128 GO:0042118 IMP involved_in endothelial cell activation 21330551 Process
17128 GO:0042127 IGI acts_upstream_of_or_within regulation of cell population proliferation 10708962,11809702 Process
17128 GO:0042127 IMP acts_upstream_of_or_within regulation of cell population proliferation 10708962 Process
17128 GO:0042733 IMP involved_in embryonic digit morphogenesis 23034633 Process
17128 GO:0045893 IDA acts_upstream_of_or_within positive regulation of DNA-templated transcription 15282343 Process
17128 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 9702197,16556916,19251704 Process
17128 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 19366691,21330551 Process
17128 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 17159989,17568773,18986983,24739304 Process
17128 GO:0045944 IMP acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 18692037,24739304 Process
17128 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 16330325,18539898 Process
17128 GO:0046881 IGI acts_upstream_of_or_within positive regulation of follicle-stimulating hormone secretion 24739304 Process
17128 GO:0046881 IMP acts_upstream_of_or_within positive regulation of follicle-stimulating hormone secretion 24739304 Process
17128 GO:0048382 IMP acts_upstream_of mesendoderm development 26494787 Process
17128 GO:0048589 IMP acts_upstream_of_or_within developmental growth 9420335 Process
17128 GO:0048663 IMP acts_upstream_of_or_within neuron fate commitment 17698011 Process
17128 GO:0048729 IMP acts_upstream_of_or_within tissue morphogenesis 9420335 Process
17128 GO:0048733 IMP acts_upstream_of_or_within sebaceous gland development 18692037 Process
17128 GO:0048859 IMP acts_upstream_of_or_within formation of anatomical boundary 9420335 Process
17128 GO:0051098 IDA acts_upstream_of_or_within regulation of binding 15282343 Process
17128 GO:0051571 IMP involved_in positive regulation of histone H3-K4 methylation 16330325 Process
17128 GO:0051797 IMP acts_upstream_of_or_within regulation of hair follicle development 18692037 Process
17128 GO:0060065 IGI acts_upstream_of_or_within uterus development 24739304 Process
17128 GO:0060391 IMP involved_in positive regulation of SMAD protein signal transduction 14691138 Process
17128 GO:0060412 IMP involved_in ventricular septum morphogenesis 16151019 Process
17128 GO:0060956 IMP involved_in endocardial cell differentiation 21330551 Process
17128 GO:0061040 IMP acts_upstream_of_or_within female gonad morphogenesis 24739304 Process
17128 GO:0062009 IMP involved_in secondary palate development 14691138 Process
17128 GO:0070102 IDA involved_in interleukin-6-mediated signaling pathway 16330325 Process
17128 GO:0070373 IMP involved_in negative regulation of ERK1 and ERK2 cascade 16151019 Process
17128 GO:0072133 IMP involved_in metanephric mesenchyme morphogenesis 15342483 Process
17128 GO:0072134 IMP involved_in nephrogenic mesenchyme morphogenesis 15342483 Process
17128 GO:0072520 IMP acts_upstream_of_or_within seminiferous tubule development 24739304 Process
17128 GO:1902895 IMP involved_in positive regulation of miRNA transcription 23426367 Process
17128 GO:1905305 IMP involved_in negative regulation of cardiac myofibril assembly 16151019 Process
17128 GO:2000617 IMP involved_in positive regulation of histone H3-K9 acetylation 16330325 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
17128 GO:0000977 IDA enables RNA polymerase II transcription regulatory region sequence-specific DNA binding 21724602 Function
17128 GO:0000977 IGI enables RNA polymerase II transcription regulatory region sequence-specific DNA binding 21330551 Function
17128 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 14764653 Function
17128 GO:0001228 IDA enables DNA-binding transcription activator activity, RNA polymerase II-specific 19366691 Function
17128 GO:0001228 IGI enables DNA-binding transcription activator activity, RNA polymerase II-specific 21330551 Function
17128 GO:0003677 IDA enables DNA binding 12270938,15459107 Function
17128 GO:0003682 IDA enables chromatin binding 15657445,18212064 Function
17128 GO:0003700 IDA enables DNA-binding transcription factor activity 12943993,14633973,16556916 Function
17128 GO:0005515 IPI enables protein binding 12543979,14633973,14764653,15282343,16115198,18268325,21145499..... Function
17128 GO:0005518 IPI enables collagen binding 14559231 Function
17128 GO:0042802 IPI enables identical protein binding 21724602 Function
17128 GO:0061629 IPI enables RNA polymerase II-specific DNA-binding transcription factor binding 21330551 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
17128 GO:0005634 IDA located_in nucleus 14691138,18692037,19796622 Component
17128 GO:0005667 IPI part_of transcription regulator complex 9288972 Component
17128 GO:0005737 IDA located_in cytoplasm 14691138 Component
17128 GO:0090575 IDA part_of RNA polymerase II transcription regulator complex 19366691 Component