Gene Ontology

Gene Info

• Species: Worm (Caenorhabditis elegans)
• GeneID: 177924
• Symbol: sir-2.1
• Description: Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
177924	GO:0000781	IDA	located_in	chromosome, telomeric region	19380489	Component
177924	GO:0005634	IDA	located_in	nucleus	16280150,16777605	Component
177924	GO:0005737	IDA	located_in	cytoplasm	18923081	Component
177924	GO:0048471	IDA	located_in	perinuclear region of cytoplasm	18923081	Component

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
177924	GO:0005515	IPI	enables	protein binding	16777605,16860373,21909281	Function
177924	GO:0019213	IDA	enables	deacetylase activity	15254550	Function

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
177924	GO:0006476	IDA	involved_in	protein deacetylation	15254550	Process
177924	GO:0008340	IMP	involved_in	determination of adult lifespan	15254550,23870130	Process
177924	GO:0008630	IMP	involved_in	intrinsic apoptotic signaling pathway in response to DNA damage	18923081	Process
177924	GO:0040024	IGI	involved_in	dauer larval development	11242085	Process
177924	GO:0043970	IDA	involved_in	histone H3-K9 acetylation	19380489	Process
177924	GO:0043970	IMP	involved_in	histone H3-K9 acetylation	19380489	Process
177924	GO:0070932	IDA	involved_in	histone H3 deacetylation	19380489	Process
177924	GO:0070932	IMP	involved_in	histone H3 deacetylation	19380489	Process