Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 18189
  • Symbol: Nrxn1
  • Description: neurexin I

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18189 GO:0004888 IDA enables transmembrane signaling receptor activity 12796785 Function
18189 GO:0005246 IGI enables calcium channel regulator activity 12827191 Function
18189 GO:0005515 IPI enables protein binding 19816407,20537373,21356198,24094106,29107521,29782851..... Function
18189 GO:0033130 IDA enables acetylcholine receptor binding 19567877 Function
18189 GO:0048306 IDA enables calcium-dependent protein binding 19098102 Function
18189 GO:0050839 IPI enables cell adhesion molecule binding 12796785,19098102,21424692 Function
18189 GO:0097109 IPI enables neuroligin family protein binding 12796785,19098102,21424692 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18189 GO:0005783 IDA located_in endoplasmic reticulum 19036990 Component
18189 GO:0009986 IDA located_in cell surface 19098102,21424692 Component
18189 GO:0031965 IDA located_in nuclear membrane 19036990 Component
18189 GO:0031982 IDA located_in vesicle 19036990 Component
18189 GO:0032991 IPI part_of protein-containing complex 24613359 Component
18189 GO:0042734 IDA is_active_in presynaptic membrane 19036990,27872870 Component
18189 GO:0042734 IDA located_in presynaptic membrane 12827191 Component
18189 GO:0042734 IMP is_active_in presynaptic membrane 19036990,27872870 Component
18189 GO:0043025 IDA located_in neuronal cell body 19036990 Component
18189 GO:0044295 IDA located_in axonal growth cone 12796785 Component
18189 GO:0048787 IDA is_active_in presynaptic active zone membrane 17360903 Component
18189 GO:0048787 IMP is_active_in presynaptic active zone membrane 17360903 Component
18189 GO:0098635 EXP part_of protein complex involved in cell-cell adhesion 18084303 Component
18189 GO:0098685 IDA is_active_in Schaffer collateral - CA1 synapse 19036990,19822762 Component
18189 GO:0098685 IMP is_active_in Schaffer collateral - CA1 synapse 19036990,19822762 Component
18189 GO:0098978 IDA is_active_in glutamatergic synapse 15620359,17360903,19036990,21410790,31995730 Component
18189 GO:0098978 IMP is_active_in glutamatergic synapse 15620359,17360903,19036990,21410790,31995730 Component
18189 GO:0098978 IPI is_active_in glutamatergic synapse 21410790,31995730 Component
18189 GO:0098982 IDA is_active_in GABA-ergic synapse 15620359 Component
18189 GO:0098982 IMP is_active_in GABA-ergic synapse 15620359 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18189 GO:0007157 IDA involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 12796785 Process
18189 GO:0007157 IGI involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 20537373 Process
18189 GO:0007158 IDA involved_in neuron cell-cell adhesion 12796785 Process
18189 GO:0007165 IDA involved_in signal transduction 12796785 Process
18189 GO:0007268 IGI acts_upstream_of_or_within chemical synaptic transmission 12827191 Process
18189 GO:0007269 IGI acts_upstream_of_or_within neurotransmitter secretion 12827191 Process
18189 GO:0007416 IDA involved_in synapse assembly 31995730 Process
18189 GO:0007416 IGI acts_upstream_of synapse assembly 21356198 Process
18189 GO:0007416 IGI acts_upstream_of_or_within synapse assembly 12827191 Process
18189 GO:0007416 IMP involved_in synapse assembly 31995730 Process
18189 GO:0007416 IPI involved_in synapse assembly 31995730 Process
18189 GO:0007612 IMP acts_upstream_of learning 19822762 Process
18189 GO:0016339 IDA involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 12796785 Process
18189 GO:0021707 IGI involved_in cerebellar granule cell differentiation 20537373 Process
18189 GO:0030534 IMP acts_upstream_of adult behavior 19822762 Process
18189 GO:0035418 IDA involved_in protein localization to synapse 12796785 Process
18189 GO:0042551 IDA involved_in neuron maturation 15620359 Process
18189 GO:0045184 IDA involved_in establishment of protein localization 12796785 Process
18189 GO:0046847 IMP involved_in filopodium assembly 20869594 Process
18189 GO:0050885 IMP acts_upstream_of neuromuscular process controlling balance 19822762 Process
18189 GO:0051490 IDA involved_in negative regulation of filopodium assembly 20869594 Process
18189 GO:0051965 IGI acts_upstream_of_or_within positive regulation of synapse assembly 21356198 Process
18189 GO:0051968 IDA involved_in positive regulation of synaptic transmission, glutamatergic 19098102 Process
18189 GO:0051968 IMP involved_in positive regulation of synaptic transmission, glutamatergic 19822762 Process
18189 GO:0060134 IMP involved_in prepulse inhibition 19822762 Process
18189 GO:0090126 IDA involved_in protein-containing complex assembly involved in synapse maturation 12796785 Process
18189 GO:0090129 IDA acts_upstream_of_or_within positive regulation of synapse maturation 19567877 Process
18189 GO:0097091 IDA involved_in synaptic vesicle clustering 12796785 Process
18189 GO:0097104 IDA involved_in postsynaptic membrane assembly 15620359,21424692 Process
18189 GO:0097105 IDA involved_in presynaptic membrane assembly 12796785 Process
18189 GO:0097112 IDA involved_in gamma-aminobutyric acid receptor clustering 15620359 Process
18189 GO:0097114 IDA involved_in NMDA glutamate receptor clustering 15620359 Process
18189 GO:0097116 IDA involved_in gephyrin clustering involved in postsynaptic density assembly 15620359,21424692 Process
18189 GO:0097117 IDA involved_in guanylate kinase-associated protein clustering 15620359 Process
18189 GO:0097118 IDA involved_in neuroligin clustering involved in postsynaptic membrane assembly 15620359,21424692 Process
18189 GO:0097119 IDA involved_in postsynaptic density protein 95 clustering 15620359,21424692 Process
18189 GO:0097120 IDA involved_in receptor localization to synapse 15620359 Process
18189 GO:0098693 IDA involved_in regulation of synaptic vesicle cycle 19822762 Process
18189 GO:0098693 IMP involved_in regulation of synaptic vesicle cycle 19822762 Process
18189 GO:0099054 IDA involved_in presynapse assembly 21410790 Process
18189 GO:0099054 IMP involved_in presynapse assembly 21410790 Process
18189 GO:0099054 IPI involved_in presynapse assembly 21410790 Process
18189 GO:0099150 IDA involved_in regulation of postsynaptic specialization assembly 15620359 Process
18189 GO:0099150 IMP involved_in regulation of postsynaptic specialization assembly 15620359 Process
18189 GO:0099151 IDA involved_in regulation of postsynaptic density assembly 21410790 Process
18189 GO:0099151 IMP involved_in regulation of postsynaptic density assembly 21410790 Process
18189 GO:0099560 IDA involved_in synaptic membrane adhesion 12796785 Process
18189 GO:0099560 IMP involved_in synaptic membrane adhesion 12796785,26771491 Process
18189 GO:0150036 IDA involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 26213384 Process
18189 GO:0150036 IMP involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 26213384 Process
18189 GO:1903078 IDA involved_in positive regulation of protein localization to plasma membrane 19098102 Process
18189 GO:1905606 IDA involved_in regulation of presynapse assembly 17360903 Process
18189 GO:1905606 IMP involved_in regulation of presynapse assembly 17360903 Process
18189 GO:2000310 IDA involved_in regulation of NMDA receptor activity 19098102 Process
18189 GO:2000311 IDA involved_in regulation of AMPA receptor activity 19098102,20869594 Process
18189 GO:2000463 IDA involved_in positive regulation of excitatory postsynaptic potential 19098102 Process
18189 GO:2000463 IMP involved_in positive regulation of excitatory postsynaptic potential 19822762 Process
18189 GO:2000821 IMP acts_upstream_of regulation of grooming behavior 19822762 Process