Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 19122
  • Symbol: Prnp
  • Description: prion protein

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19122 GO:0001540 IDA enables amyloid-beta binding 19242475 Function
19122 GO:0002020 IPI enables protease binding 17573534 Function
19122 GO:0005507 IDA enables copper ion binding 12500977 Function
19122 GO:0005515 IPI enables protein binding 11571277,15301538,19242475,20133875,22285492,22542184,24225951..... Function
19122 GO:0005539 IDA enables glycosaminoglycan binding 17573534 Function
19122 GO:0019828 IDA enables aspartic-type endopeptidase inhibitor activity 17573534 Function
19122 GO:0031802 IPI enables type 5 metabotropic glutamate receptor binding 24012003 Function
19122 GO:0038023 IMP enables signaling receptor activity 19242475 Function
19122 GO:0042802 IPI enables identical protein binding 19805070,20345906,21041683,21441913,22449963,22854022,23892077..... Function
19122 GO:0044877 IPI enables protein-containing complex binding 19242475 Function
19122 GO:0046872 EXP enables metal ion binding 11438695 Function
19122 GO:0046872 IDA enables metal ion binding 11438695 Function
19122 GO:0060090 EXP enables molecular adaptor activity 29791485 Function
19122 GO:0060090 IPI enables molecular adaptor activity 28945221 Function
19122 GO:0140311 IDA enables protein sequestering activity 21441896 Function
19122 GO:0140693 EXP enables molecular condensate scaffold activity 34102212 Function
19122 GO:0140693 IDA enables molecular condensate scaffold activity 34102212 Function
19122 GO:1903135 IMP enables cupric ion binding 19381258 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19122 GO:0001933 IMP involved_in negative regulation of protein phosphorylation 20145049 Process
19122 GO:0006979 IDA acts_upstream_of_or_within response to oxidative stress 12500977 Process
19122 GO:0007611 IGI involved_in learning or memory 20445063 Process
19122 GO:0032147 IGI involved_in activation of protein kinase activity 23386614 Process
19122 GO:0032689 IMP involved_in negative regulation of type II interferon production 20145049 Process
19122 GO:0032700 IMP involved_in negative regulation of interleukin-17 production 20145049 Process
19122 GO:0032703 IMP involved_in negative regulation of interleukin-2 production 20145049 Process
19122 GO:0032880 IMP acts_upstream_of_or_within regulation of protein localization 10037495 Process
19122 GO:0035584 IGI involved_in calcium-mediated signaling using intracellular calcium source 24012003 Process
19122 GO:0042982 IGI NOT involved_in amyloid precursor protein metabolic process 20445063 Process
19122 GO:0043066 IGI acts_upstream_of_or_within negative regulation of apoptotic process 15753097 Process
19122 GO:0043433 IMP involved_in negative regulation of DNA-binding transcription factor activity 20145049 Process
19122 GO:0046007 IMP involved_in negative regulation of activated T cell proliferation 20145049 Process
19122 GO:0050730 IGI involved_in regulation of peptidyl-tyrosine phosphorylation 22820466 Process
19122 GO:0050731 IMP involved_in positive regulation of peptidyl-tyrosine phosphorylation 22820466 Process
19122 GO:0050860 IMP involved_in negative regulation of T cell receptor signaling pathway 20145049 Process
19122 GO:0070885 IMP involved_in negative regulation of calcineurin-NFAT signaling cascade 20145049 Process
19122 GO:0071466 IDA acts_upstream_of_or_within cellular response to xenobiotic stimulus 16254249 Process
19122 GO:0090314 IGI involved_in positive regulation of protein targeting to membrane 22820466 Process
19122 GO:1900449 IGI involved_in regulation of glutamate receptor signaling pathway 22820466 Process
19122 GO:1901216 IGI involved_in positive regulation of neuron death 22820466 Process
19122 GO:1901379 IGI acts_upstream_of_or_within regulation of potassium ion transmembrane transport 24225951 Process
19122 GO:1902430 IGI involved_in negative regulation of amyloid-beta formation 17573534 Process
19122 GO:1902951 IGI involved_in negative regulation of dendritic spine maintenance 22820466,24012003 Process
19122 GO:1902992 IGI involved_in negative regulation of amyloid precursor protein catabolic process 17573534 Process
19122 GO:1903078 IMP involved_in positive regulation of protein localization to plasma membrane 23386614 Process
19122 GO:1904645 IGI involved_in response to amyloid-beta 22820466 Process
19122 GO:1904646 IGI involved_in cellular response to amyloid-beta 24012003 Process
19122 GO:1905664 IGI involved_in regulation of calcium ion import across plasma membrane 22820466 Process
19122 GO:1990535 IGI involved_in neuron projection maintenance 20445063 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19122 GO:0005783 IDA located_in endoplasmic reticulum 11756421 Component
19122 GO:0005794 IDA located_in Golgi apparatus 11756421 Component
19122 GO:0005886 IDA located_in plasma membrane 9837873 Component
19122 GO:0009986 IDA located_in cell surface 16254249 Component
19122 GO:0016020 IDA located_in membrane 24225951 Component
19122 GO:0030425 IDA colocalizes_with dendrite 19242475 Component
19122 GO:0043195 IDA located_in terminal bouton 15262264 Component
19122 GO:0045121 IDA located_in membrane raft 10037495,12927782 Component
19122 GO:0045121 IMP located_in membrane raft 17573534 Component