Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 19164
  • Symbol: Psen1
  • Description: presenilin 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19164 GO:0000045 IMP acts_upstream_of_or_within autophagosome assembly 15452145 Process
19164 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 20208556 Process
19164 GO:0001568 IMP acts_upstream_of_or_within blood vessel development 9153393,15254914,16079160 Process
19164 GO:0001708 IGI acts_upstream_of_or_within cell fate specification 15525534 Process
19164 GO:0001756 IGI acts_upstream_of_or_within somitogenesis 10557208,19779553 Process
19164 GO:0001756 IMP acts_upstream_of_or_within somitogenesis 9153393 Process
19164 GO:0001764 IMP acts_upstream_of_or_within neuron migration 10421573,10821758,12391611,15163631 Process
19164 GO:0001921 IMP involved_in positive regulation of receptor recycling 20208556 Process
19164 GO:0001933 IGI acts_upstream_of_or_within negative regulation of protein phosphorylation 15148382 Process
19164 GO:0001934 IMP acts_upstream_of_or_within positive regulation of protein phosphorylation 15896720 Process
19164 GO:0001947 IGI acts_upstream_of_or_within heart looping 10557208 Process
19164 GO:0002038 IMP acts_upstream_of_or_within positive regulation of L-glutamate import across plasma membrane 15009636 Process
19164 GO:0002244 IGI acts_upstream_of_or_within hematopoietic progenitor cell differentiation 15122901 Process
19164 GO:0002286 IGI acts_upstream_of_or_within T cell activation involved in immune response 17698590 Process
19164 GO:0002573 IGI acts_upstream_of_or_within myeloid leukocyte differentiation 15122901 Process
19164 GO:0006469 IMP acts_upstream_of_or_within negative regulation of protein kinase activity 12805290 Process
19164 GO:0006486 IMP acts_upstream_of_or_within protein glycosylation 12646573 Process
19164 GO:0006839 IMP acts_upstream_of_or_within mitochondrial transport 12805290 Process
19164 GO:0006874 IMP acts_upstream_of_or_within intracellular calcium ion homeostasis 12431992 Process
19164 GO:0006914 IMP acts_upstream_of_or_within autophagy 15123735 Process
19164 GO:0006974 IMP acts_upstream_of_or_within DNA damage response 12460542 Process
19164 GO:0006979 IGI acts_upstream_of_or_within response to oxidative stress 16478525 Process
19164 GO:0006979 IMP acts_upstream_of_or_within response to oxidative stress 10097174 Process
19164 GO:0007175 IMP involved_in negative regulation of epidermal growth factor-activated receptor activity 20208556 Process
19164 GO:0007176 IGI acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity 17556541 Process
19164 GO:0007219 IGI acts_upstream_of_or_within Notch signaling pathway 17698590 Process
19164 GO:0007219 IMP acts_upstream_of_or_within Notch signaling pathway 10821758,11262239,16715081 Process
19164 GO:0007220 IMP acts_upstream_of_or_within Notch receptor processing 10206645,12391611,20130175 Process
19164 GO:0007420 IMP acts_upstream_of_or_within brain development 9153393 Process
19164 GO:0007507 IMP acts_upstream_of_or_within heart development 15254914 Process
19164 GO:0007611 IGI acts_upstream_of_or_within learning or memory 15066262 Process
19164 GO:0007613 IGI acts_upstream_of_or_within memory 15148382,17614943 Process
19164 GO:0007613 IMP acts_upstream_of_or_within memory 11567612,11738035 Process
19164 GO:0009790 IGI acts_upstream_of_or_within embryo development 10518543,10557208 Process
19164 GO:0009790 IMP acts_upstream_of_or_within embryo development 12391611,16079160 Process
19164 GO:0009791 IMP acts_upstream_of_or_within post-embryonic development 10518543 Process
19164 GO:0010467 IMP acts_upstream_of_or_within_positive_effect gene expression 15009636 Process
19164 GO:0015031 IGI acts_upstream_of_or_within protein transport 11943765 Process
19164 GO:0015871 IMP acts_upstream_of_or_within choline transport 17196556 Process
19164 GO:0016080 IMP acts_upstream_of_or_within synaptic vesicle targeting 12805290 Process
19164 GO:0016485 IMP acts_upstream_of_or_within protein processing 10206645,11567612 Process
19164 GO:0019538 IDA acts_upstream_of_or_within protein metabolic process 17097608 Process
19164 GO:0019538 IGI acts_upstream_of_or_within protein metabolic process 17097608 Process
19164 GO:0019538 IMP acts_upstream_of_or_within protein metabolic process 11953314 Process
19164 GO:0021795 IMP acts_upstream_of_or_within cerebral cortex cell migration 16079160 Process
19164 GO:0021870 IMP acts_upstream_of_or_within Cajal-Retzius cell differentiation 15548218 Process
19164 GO:0021904 IGI acts_upstream_of_or_within dorsal/ventral neural tube patterning 10557208 Process
19164 GO:0021987 IMP acts_upstream_of_or_within cerebral cortex development 16079160 Process
19164 GO:0022008 IMP acts_upstream_of_or_within neurogenesis 9160754,11738035 Process
19164 GO:0030182 IMP acts_upstream_of_or_within neuron differentiation 10821758 Process
19164 GO:0030326 IGI acts_upstream_of_or_within embryonic limb morphogenesis 16169548 Process
19164 GO:0030900 IGI acts_upstream_of_or_within forebrain development 15148382 Process
19164 GO:0032436 IMP involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 20208556 Process
19164 GO:0032469 IGI acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis 17431506 Process
19164 GO:0032469 IMP acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis 10662826,12460542,15009636,15123735 Process
19164 GO:0034205 IGI acts_upstream_of_or_within amyloid-beta formation 16371134 Process
19164 GO:0034205 IMP acts_upstream_of_or_within amyloid-beta formation 16371134,20130175 Process
19164 GO:0035282 IMP acts_upstream_of_or_within segmentation 11262239,16079160 Process
19164 GO:0040011 IGI acts_upstream_of_or_within locomotion 15148382 Process
19164 GO:0042640 IGI acts_upstream_of_or_within anagen 15525534 Process
19164 GO:0042987 IMP acts_upstream_of_or_within amyloid precursor protein catabolic process 10206645,11567612,15452145 Process
19164 GO:0043011 IMP acts_upstream_of_or_within myeloid dendritic cell differentiation 23913046 Process
19164 GO:0043065 IGI acts_upstream_of_or_within positive regulation of apoptotic process 16169548 Process
19164 GO:0043066 IDA acts_upstream_of_or_within negative regulation of apoptotic process 15192701 Process
19164 GO:0043393 IGI acts_upstream_of_or_within regulation of protein binding 17920016 Process
19164 GO:0043406 IMP acts_upstream_of_or_within positive regulation of MAP kinase activity 15896720 Process
19164 GO:0043589 IMP involved_in skin morphogenesis 20208556 Process
19164 GO:0045860 IDA acts_upstream_of_or_within positive regulation of protein kinase activity 15192701 Process
19164 GO:0048167 IGI acts_upstream_of_or_within regulation of synaptic plasticity 15066262 Process
19164 GO:0048167 IMP acts_upstream_of_or_within regulation of synaptic plasticity 11814648 Process
19164 GO:0048538 IGI acts_upstream_of_or_within thymus development 17698590 Process
19164 GO:0048538 IMP acts_upstream_of_or_within thymus development 17698590 Process
19164 GO:0048666 IMP acts_upstream_of_or_within neuron development 12391611 Process
19164 GO:0048666 IMP involved_in neuron development 21325529 Process
19164 GO:0048705 IMP acts_upstream_of_or_within skeletal system morphogenesis 9160754 Process
19164 GO:0048854 IGI acts_upstream_of_or_within brain morphogenesis 17614943 Process
19164 GO:0050435 IMP acts_upstream_of_or_within amyloid-beta metabolic process 12684521 Process
19164 GO:0050673 IGI acts_upstream_of_or_within epithelial cell proliferation 17913918 Process
19164 GO:0050771 IMP acts_upstream_of_or_within negative regulation of axonogenesis 15548218 Process
19164 GO:0050820 IMP acts_upstream_of_or_within positive regulation of coagulation 12646573 Process
19164 GO:0050852 IGI acts_upstream_of_or_within T cell receptor signaling pathway 17698590 Process
19164 GO:0051208 IMP acts_upstream_of_or_within_positive_effect sequestering of calcium ion 15009636 Process
19164 GO:0051402 IGI acts_upstream_of_or_within neuron apoptotic process 16478525 Process
19164 GO:0051444 IMP involved_in negative regulation of ubiquitin-protein transferase activity 20208556 Process
19164 GO:0051563 IGI acts_upstream_of_or_within smooth endoplasmic reticulum calcium ion homeostasis 12431992 Process
19164 GO:0051604 IGI acts_upstream_of_or_within protein maturation 11943765,15280425 Process
19164 GO:0051966 IMP acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic 10097174 Process
19164 GO:0060075 IMP acts_upstream_of_or_within regulation of resting membrane potential 15548218 Process
19164 GO:0060828 IMP involved_in regulation of canonical Wnt signaling pathway 11517342 Process
19164 GO:0070050 IGI acts_upstream_of_or_within neuron cellular homeostasis 12431992 Process
19164 GO:0070050 IMP acts_upstream_of_or_within neuron cellular homeostasis 12431992 Process
19164 GO:0097190 IGI acts_upstream_of apoptotic signaling pathway 15148382 Process
19164 GO:0098693 IDA involved_in regulation of synaptic vesicle cycle 17088253 Process
19164 GO:0098693 IMP involved_in regulation of synaptic vesicle cycle 17088253 Process
19164 GO:0098712 IMP acts_upstream_of_or_within_positive_effect L-glutamate import across plasma membrane 15009636 Process
19164 GO:0099175 IDA involved_in regulation of postsynapse organization 23083742 Process
19164 GO:0099175 IEP involved_in regulation of postsynapse organization 23083742 Process
19164 GO:0099175 IMP involved_in regulation of postsynapse organization 23083742 Process
19164 GO:0140249 IDA involved_in protein catabolic process at postsynapse 23083742 Process
19164 GO:0140249 IEP involved_in protein catabolic process at postsynapse 23083742 Process
19164 GO:0140249 IMP involved_in protein catabolic process at postsynapse 23083742 Process
19164 GO:2000059 IMP involved_in negative regulation of ubiquitin-dependent protein catabolic process 20208556 Process
19164 GO:2001234 IGI acts_upstream_of_or_within negative regulation of apoptotic signaling pathway 15148382 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19164 GO:0004175 IGI enables endopeptidase activity 17920016 Function
19164 GO:0004175 IMP enables endopeptidase activity 10206645,11262239,11953314,12391611,15452145,17097608,17556541..... Function
19164 GO:0004190 IMP enables aspartic-type endopeptidase activity 12684521 Function
19164 GO:0005515 IPI enables protein binding 10854253,11719200,12522139,12794186,12805290,15192701,15474363..... Function
19164 GO:0042500 IGI contributes_to aspartic endopeptidase activity, intramembrane cleaving 16371134 Function
19164 GO:0042500 IGI enables aspartic endopeptidase activity, intramembrane cleaving 21206757 Function
19164 GO:0042500 IMP contributes_to aspartic endopeptidase activity, intramembrane cleaving 16371134 Function
19164 GO:0045296 IPI enables cadherin binding 11953314 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19164 GO:0005622 IDA located_in intracellular anatomical structure 10421573 Component
19164 GO:0005634 IDA located_in nucleus 12794186 Component
19164 GO:0005737 IDA located_in cytoplasm 11517342 Component
19164 GO:0005783 IDA located_in endoplasmic reticulum 10854253,19376115 Component
19164 GO:0005794 IDA located_in Golgi apparatus 16018997,19376115 Component
19164 GO:0005886 IDA located_in plasma membrane 11517342,17097608 Component
19164 GO:0005938 IDA located_in cell cortex 11517342 Component
19164 GO:0016020 IDA located_in membrane 10854253,12684521,15474363,15634781,15886206 Component
19164 GO:0030424 IDA located_in axon 11740561 Component
19164 GO:0030425 IDA located_in dendrite 8922407 Component
19164 GO:0030426 IDA located_in growth cone 12805290 Component
19164 GO:0031410 IDA located_in cytoplasmic vesicle 11740561 Component
19164 GO:0035253 IDA located_in ciliary rootlet 16018997 Component
19164 GO:0043025 IDA located_in neuronal cell body 8922407,12805290 Component
19164 GO:0043198 IDA located_in dendritic shaft 12805290 Component
19164 GO:0043227 IDA located_in membrane-bounded organelle 12805290 Component
19164 GO:0070765 IDA part_of gamma-secretase complex 12684521,16371134,16641999,20674680 Component
19164 GO:0098978 IDA is_active_in glutamatergic synapse 23083742 Component
19164 GO:0098978 IEP is_active_in glutamatergic synapse 23083742 Component
19164 GO:0098978 IMP is_active_in glutamatergic synapse 23083742 Component