Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 19165
  • Symbol: Psen2
  • Description: presenilin 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19165 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 20208556 Process
19165 GO:0001708 IGI acts_upstream_of_or_within cell fate specification 15525534 Process
19165 GO:0001756 IGI acts_upstream_of_or_within somitogenesis 10557208,19779553 Process
19165 GO:0001921 IMP involved_in positive regulation of receptor recycling 20208556 Process
19165 GO:0001933 IGI acts_upstream_of_or_within negative regulation of protein phosphorylation 15148382 Process
19165 GO:0001942 IGI acts_upstream_of_or_within hair follicle development 10557208 Process
19165 GO:0002244 IGI acts_upstream_of_or_within hematopoietic progenitor cell differentiation 15122901 Process
19165 GO:0002286 IGI acts_upstream_of_or_within T cell activation involved in immune response 17698590 Process
19165 GO:0002573 IGI acts_upstream_of_or_within myeloid leukocyte differentiation 15122901 Process
19165 GO:0006816 IPI acts_upstream_of_or_within calcium ion transport 16204356 Process
19165 GO:0007175 IMP involved_in negative regulation of epidermal growth factor-activated receptor activity 20208556 Process
19165 GO:0007176 IGI acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity 17556541 Process
19165 GO:0007219 IGI acts_upstream_of_or_within Notch signaling pathway 17698590 Process
19165 GO:0007611 IGI acts_upstream_of_or_within learning or memory 15066262 Process
19165 GO:0007613 IGI acts_upstream_of_or_within memory 15148382,17614943 Process
19165 GO:0009790 IGI acts_upstream_of_or_within embryo development 10518543,10557208 Process
19165 GO:0010934 IGI acts_upstream_of_or_within macrophage cytokine production 21206757 Process
19165 GO:0010934 IMP acts_upstream_of_or_within macrophage cytokine production 21206757 Process
19165 GO:0015031 IGI acts_upstream_of_or_within protein transport 11943765 Process
19165 GO:0016485 IGI acts_upstream_of_or_within protein processing 15280425 Process
19165 GO:0019538 IGI acts_upstream_of_or_within protein metabolic process 17097608 Process
19165 GO:0021904 IGI acts_upstream_of_or_within dorsal/ventral neural tube patterning 10557208 Process
19165 GO:0030326 IGI acts_upstream_of_or_within embryonic limb morphogenesis 16169548 Process
19165 GO:0030900 IGI acts_upstream_of_or_within forebrain development 15148382 Process
19165 GO:0032436 IMP involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 20208556 Process
19165 GO:0032469 IGI acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis 12460542 Process
19165 GO:0032635 IGI acts_upstream_of_or_within interleukin-6 production 21206757 Process
19165 GO:0032635 IMP acts_upstream_of_or_within interleukin-6 production 21206757 Process
19165 GO:0032640 IGI acts_upstream_of_or_within tumor necrosis factor production 21206757 Process
19165 GO:0032640 IMP acts_upstream_of_or_within tumor necrosis factor production 21206757 Process
19165 GO:0040011 IGI acts_upstream_of_or_within locomotion 15148382 Process
19165 GO:0042640 IGI acts_upstream_of_or_within anagen 15525534 Process
19165 GO:0043065 IGI acts_upstream_of_or_within positive regulation of apoptotic process 16169548 Process
19165 GO:0043393 IGI acts_upstream_of_or_within regulation of protein binding 17920016 Process
19165 GO:0043589 IMP involved_in skin morphogenesis 20208556 Process
19165 GO:0048167 IGI acts_upstream_of_or_within regulation of synaptic plasticity 15066262 Process
19165 GO:0048286 IMP acts_upstream_of_or_within lung alveolus development 10518543 Process
19165 GO:0048538 IGI acts_upstream_of_or_within thymus development 17698590 Process
19165 GO:0048854 IGI acts_upstream_of_or_within brain morphogenesis 17614943 Process
19165 GO:0050435 IDA acts_upstream_of_or_within amyloid-beta metabolic process 10846187 Process
19165 GO:0050435 IMP acts_upstream_of_or_within amyloid-beta metabolic process 12684521 Process
19165 GO:0050820 IMP acts_upstream_of_or_within positive regulation of coagulation 12646573 Process
19165 GO:0050852 IGI acts_upstream_of_or_within T cell receptor signaling pathway 17698590 Process
19165 GO:0051444 IMP involved_in negative regulation of ubiquitin-protein transferase activity 20208556 Process
19165 GO:0051604 IGI acts_upstream_of_or_within protein maturation 11943765 Process
19165 GO:0060048 IMP acts_upstream_of_or_within cardiac muscle contraction 16204356 Process
19165 GO:0070050 IGI involved_in neuron cellular homeostasis 25429133 Process
19165 GO:0097190 IGI acts_upstream_of apoptotic signaling pathway 15148382 Process
19165 GO:0099175 IDA involved_in regulation of postsynapse organization 23083742 Process
19165 GO:0099175 IEP involved_in regulation of postsynapse organization 23083742 Process
19165 GO:0099175 IMP involved_in regulation of postsynapse organization 23083742 Process
19165 GO:0140249 IDA involved_in protein catabolic process at postsynapse 23083742 Process
19165 GO:0140249 IEP involved_in protein catabolic process at postsynapse 23083742 Process
19165 GO:0140249 IMP involved_in protein catabolic process at postsynapse 23083742 Process
19165 GO:0150076 IGI acts_upstream_of_or_within neuroinflammatory response 21206757 Process
19165 GO:0150076 IMP acts_upstream_of_or_within neuroinflammatory response 21206757 Process
19165 GO:1902043 IDA acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 8940094 Process
19165 GO:2000059 IMP involved_in negative regulation of ubiquitin-dependent protein catabolic process 20208556 Process
19165 GO:2001234 IGI acts_upstream_of_or_within negative regulation of apoptotic signaling pathway 15148382 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19165 GO:0004175 IGI enables endopeptidase activity 17920016 Function
19165 GO:0004175 IMP enables endopeptidase activity 17556541 Function
19165 GO:0005515 IPI enables protein binding 11719200,15474363,16204356 Function
19165 GO:0042500 IGI enables aspartic endopeptidase activity, intramembrane cleaving 21206757 Function
19165 GO:0042500 IMP enables aspartic endopeptidase activity, intramembrane cleaving 12684521,21206757 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
19165 GO:0005829 IDA located_in cytosol 9535056 Component
19165 GO:0016020 IDA located_in membrane 9535056,9950750,12684521,15886206 Component
19165 GO:0030018 IDA located_in Z disc 16204356 Component
19165 GO:0036064 IDA located_in ciliary basal body 21703454 Component
19165 GO:0043025 IDA located_in neuronal cell body 9203550 Component
19165 GO:0070765 IDA part_of gamma-secretase complex 12684521 Component
19165 GO:0098978 IDA is_active_in glutamatergic synapse 23083742 Component
19165 GO:0098978 IEP is_active_in glutamatergic synapse 23083742 Component
19165 GO:0098978 IMP is_active_in glutamatergic synapse 23083742 Component