Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 1956
  • Symbol: EGFR
  • Description: epidermal growth factor receptor

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1956 GO:0001934 IDA involved_in positive regulation of protein phosphorylation 20551055 Process
1956 GO:0007165 IDA involved_in signal transduction 10572067 Process
1956 GO:0007166 IDA acts_upstream_of_or_within cell surface receptor signaling pathway 7736574 Process
1956 GO:0007173 IDA acts_upstream_of_or_within epidermal growth factor receptor signaling pathway 7736574 Process
1956 GO:0007173 IDA involved_in epidermal growth factor receptor signaling pathway 9890893,12435727 Process
1956 GO:0007173 IMP involved_in epidermal growth factor receptor signaling pathway 20878056 Process
1956 GO:0008284 IDA acts_upstream_of_or_within positive regulation of cell population proliferation 7736574 Process
1956 GO:0008284 IMP involved_in positive regulation of cell population proliferation 27057632 Process
1956 GO:0010750 IDA involved_in positive regulation of nitric oxide mediated signal transduction 12828935 Process
1956 GO:0014066 IMP involved_in regulation of phosphatidylinositol 3-kinase signaling 26514923 Process
1956 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 22732145 Process
1956 GO:0030307 IDA involved_in positive regulation of cell growth 15467833 Process
1956 GO:0030335 IMP involved_in positive regulation of cell migration 12435727,25678558 Process
1956 GO:0033138 IMP involved_in positive regulation of peptidyl-serine phosphorylation 20878056 Process
1956 GO:0034614 IMP involved_in cellular response to reactive oxygen species 26514923 Process
1956 GO:0038083 IMP involved_in peptidyl-tyrosine autophosphorylation 20878056 Process
1956 GO:0038134 IDA involved_in ERBB2-EGFR signaling pathway 11336639 Process
1956 GO:0042177 IDA involved_in negative regulation of protein catabolic process 17115032 Process
1956 GO:0042327 IDA involved_in positive regulation of phosphorylation 15082764 Process
1956 GO:0043066 IMP involved_in negative regulation of apoptotic process 18070883 Process
1956 GO:0043406 IDA involved_in positive regulation of MAP kinase activity 10572067 Process
1956 GO:0045737 IMP involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity 18483258 Process
1956 GO:0045739 IDA involved_in positive regulation of DNA repair 17115032 Process
1956 GO:0045740 IDA involved_in positive regulation of DNA replication 17115032 Process
1956 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 26514923 Process
1956 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 20551055 Process
1956 GO:0046328 IMP involved_in regulation of JNK cascade 26514923 Process
1956 GO:0046777 IMP involved_in protein autophosphorylation 18070883 Process
1956 GO:0050679 IDA involved_in positive regulation of epithelial cell proliferation 10572067 Process
1956 GO:0050730 IMP involved_in regulation of peptidyl-tyrosine phosphorylation 12435727 Process
1956 GO:0050999 IDA involved_in regulation of nitric-oxide synthase activity 12828935 Process
1956 GO:0051897 IMP involved_in positive regulation of protein kinase B signaling 17655843 Process
1956 GO:0070141 IDA involved_in response to UV-A 18483258 Process
1956 GO:0070372 IMP involved_in regulation of ERK1 and ERK2 cascade 26514923 Process
1956 GO:0070374 IDA involved_in positive regulation of ERK1 and ERK2 cascade 20551055 Process
1956 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 21673316 Process
1956 GO:0071276 IMP involved_in cellular response to cadmium ion 26514923 Process
1956 GO:0071392 IDA involved_in cellular response to estradiol stimulus 20551055 Process
1956 GO:0090263 IMP involved_in positive regulation of canonical Wnt signaling pathway 20302655 Process
1956 GO:0098609 IMP involved_in cell-cell adhesion 12435727 Process
1956 GO:1900020 IDA involved_in positive regulation of protein kinase C activity 22732145 Process
1956 GO:1900087 IMP involved_in positive regulation of G1/S transition of mitotic cell cycle 18483258 Process
1956 GO:1901224 IMP involved_in positive regulation of NIK/NF-kappaB signaling 26514923 Process
1956 GO:1902895 IMP involved_in positive regulation of miRNA transcription 21673316 Process
1956 GO:1903078 IDA involved_in positive regulation of protein localization to plasma membrane 22732145 Process
1956 GO:1905208 IMP involved_in negative regulation of cardiocyte differentiation 23069713 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1956 GO:0003682 IDA enables chromatin binding 20551055 Function
1956 GO:0004713 IDA enables protein tyrosine kinase activity 2472218,9890893,17115032,17599051 Function
1956 GO:0004713 IMP enables protein tyrosine kinase activity 14702346,20878056 Function
1956 GO:0004888 IDA enables transmembrane signaling receptor activity 7736574 Function
1956 GO:0005006 IDA enables epidermal growth factor receptor activity 2176151,11336639,12435727,17115032 Function
1956 GO:0005006 IMP enables epidermal growth factor receptor activity 22732145 Function
1956 GO:0019899 IPI enables enzyme binding 12009895 Function
1956 GO:0019900 IPI enables kinase binding 18722344 Function
1956 GO:0019903 IPI enables protein phosphatase binding 15899872,28759036 Function
1956 GO:0030235 IDA contributes_to nitric-oxide synthase regulator activity 12828935 Function
1956 GO:0030296 IDA enables protein tyrosine kinase activator activity 2176151,11336639 Function
1956 GO:0031625 IPI enables ubiquitin protein ligase binding 23418353 Function
1956 GO:0042802 IPI enables identical protein binding 16777603,17148612,18042729,19563760,19650109,20007378,20029029..... Function
1956 GO:0045296 HDA enables cadherin binding 25468996 Function
1956 GO:0051015 IDA enables actin filament binding 14702346 Function
1956 GO:0005515 IPI enables protein binding 2176151,2790960,7518560,7542744,7657591,7685104,7693694,779755..... Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1956 GO:0005634 IDA located_in nucleus 12828935,17115032,20551055 Component
1956 GO:0005737 IDA located_in cytoplasm 7588596,12435727,22298428 Component
1956 GO:0005768 IDA colocalizes_with endosome 16554368 Component
1956 GO:0005768 IDA located_in endosome 14702346,17182860,22732145 Component
1956 GO:0005886 IDA is_active_in plasma membrane 11331309,11336639,15611079 Component
1956 GO:0005886 IDA located_in plasma membrane 15465819,20462955,22298428,22732145 Component
1956 GO:0005925 HDA located_in focal adhesion 21423176 Component
1956 GO:0009986 IDA located_in cell surface 25666625 Component
1956 GO:0010008 IDA located_in endosome membrane 22719997 Component
1956 GO:0016020 IDA located_in membrane 12435727 Component
1956 GO:0016323 IDA located_in basolateral plasma membrane 12646923 Component
1956 GO:0030054 IDA located_in cell junction Component
1956 GO:0031901 IDA located_in early endosome membrane 17714434 Component
1956 GO:0032587 IDA is_active_in ruffle membrane 11331309 Component
1956 GO:0032991 IDA part_of protein-containing complex 20878056 Component
1956 GO:0043235 IDA part_of receptor complex 23382219 Component
1956 GO:0045121 IDA located_in membrane raft 12009895 Component
1956 GO:0048471 IMP located_in perinuclear region of cytoplasm 24854121 Component
1956 GO:0097489 IDA located_in multivesicular body, internal vesicle lumen 17714434 Component
1956 GO:0097708 IDA located_in intracellular vesicle 11331309 Component