Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 20191
  • Symbol: Ryr2
  • Description: ryanodine receptor 2, cardiac

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
20191 GO:0001666 IDA involved_in response to hypoxia 19120137 Process
20191 GO:0002027 IMP involved_in regulation of heart rate 17872467 Process
20191 GO:0003143 IMP involved_in embryonic heart tube morphogenesis 9628868 Process
20191 GO:0003220 IMP acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis 17431507 Process
20191 GO:0003300 IMP acts_upstream_of_or_within cardiac muscle hypertrophy 17431507 Process
20191 GO:0006816 IDA acts_upstream_of_or_within calcium ion transport 14593104 Process
20191 GO:0006816 IDA involved_in calcium ion transport 10473538 Process
20191 GO:0006816 IMP involved_in calcium ion transport 9628868 Process
20191 GO:0006816 IPI acts_upstream_of_or_within calcium ion transport 16204356 Process
20191 GO:0006874 IMP involved_in intracellular calcium ion homeostasis 9628868 Process
20191 GO:0010460 IMP acts_upstream_of_or_within positive regulation of heart rate 12089338,17431507 Process
20191 GO:0010881 IGI involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 12837242 Process
20191 GO:0014808 IDA involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 20226167 Process
20191 GO:0014808 IMP acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 12089338 Process
20191 GO:0019722 IMP involved_in calcium-mediated signaling 9628868 Process
20191 GO:0031000 IDA acts_upstream_of_or_within response to caffeine 14593104 Process
20191 GO:0031000 IDA involved_in response to caffeine 10473538 Process
20191 GO:0051649 IMP acts_upstream_of_or_within establishment of localization in cell 12089338 Process
20191 GO:0070588 IMP acts_upstream_of_or_within calcium ion transmembrane transport 21673970 Process
20191 GO:0071313 IDA acts_upstream_of_or_within cellular response to caffeine 12089338 Process
20191 GO:0071313 IDA involved_in cellular response to caffeine 9628868,22406107 Process
20191 GO:0071872 IMP involved_in cellular response to epinephrine stimulus 17872467 Process
20191 GO:0086005 IMP involved_in ventricular cardiac muscle cell action potential 17872467 Process
20191 GO:0086029 IMP involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling 17872467 Process
20191 GO:0097050 IMP involved_in type B pancreatic cell apoptotic process 15044459 Process
20191 GO:0097553 IMP acts_upstream_of_or_within calcium ion transmembrane import into cytosol 17431507 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
20191 GO:0005219 IDA enables ryanodine-sensitive calcium-release channel activity 14593104,17431507 Function
20191 GO:0005262 IDA enables calcium channel activity 9628868 Function
20191 GO:0005515 IPI enables protein binding 16352659,16481613,20479242,21788490,22939628,23540699,24805197..... Function
20191 GO:0005516 IDA enables calmodulin binding 17431507 Function
20191 GO:0015278 IDA enables calcium-release channel activity 10473538 Function
20191 GO:0019899 IPI enables enzyme binding 16213210,20080623,22406107 Function
20191 GO:0019901 IPI enables protein kinase binding 12676814 Function
20191 GO:0042802 IPI enables identical protein binding 12324472,20427316 Function
20191 GO:0043621 IMP enables protein self-association 10473538 Function
20191 GO:0097159 IPI enables organic cyclic compound binding 17431507 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
20191 GO:0005790 IDA located_in smooth endoplasmic reticulum 23454728 Component
20191 GO:0016020 IDA located_in membrane 17431507 Component
20191 GO:0016529 IDA located_in sarcoplasmic reticulum 12919952,21788490,22406107 Component
20191 GO:0030017 IDA located_in sarcomere 20226167 Component
20191 GO:0030018 IDA located_in Z disc 16204356,19383796 Component
20191 GO:0033017 IDA located_in sarcoplasmic reticulum membrane 14592808,16481613 Component
20191 GO:0034704 IDA part_of calcium channel complex 16213210 Component