Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 2064
  • Symbol: ERBB2
  • Description: erb-b2 receptor tyrosine kinase 2

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2064 GO:0001042 IDA enables RNA polymerase I core binding 21555369 Function
2064 GO:0004713 IDA enables protein tyrosine kinase activity 7556068,12000754 Function
2064 GO:0004714 IDA enables transmembrane receptor protein tyrosine kinase activity 7514177 Function
2064 GO:0004888 IDA enables transmembrane signaling receptor activity 7514177 Function
2064 GO:0005515 IPI enables protein binding 7592681,9079677,9705354,10572067,10805725,11940572,12061724,12..... Function
2064 GO:0019838 IDA contributes_to growth factor binding 7514177 Function
2064 GO:0042802 IPI enables identical protein binding 12000754,16843263,17148612,19650109,21203579,21255571,21480528..... Function
2064 GO:0043125 IPI enables ErbB-3 class receptor binding 12000754 Function
2064 GO:0046982 IPI enables protein heterodimerization activity 7556068 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2064 GO:0005634 IDA located_in nucleus 16314522,21555369 Component
2064 GO:0005654 IDA located_in nucleoplasm Component
2064 GO:0005829 IDA located_in cytosol Component
2064 GO:0005886 IDA located_in plasma membrane 20010870 Component
2064 GO:0010008 IDA located_in endosome membrane 16314522 Component
2064 GO:0016323 IDA located_in basolateral plasma membrane 12646923 Component
2064 GO:0038143 IDA part_of ERBB3:ERBB2 complex 12000754 Component
2064 GO:0043235 IDA part_of receptor complex 7514177,23382219 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2064 GO:0007165 IDA involved_in signal transduction 10572067 Process
2064 GO:0007166 IDA acts_upstream_of_or_within cell surface receptor signaling pathway 9685399 Process
2064 GO:0007169 IDA involved_in transmembrane receptor protein tyrosine kinase signaling pathway 7514177 Process
2064 GO:0014065 IDA involved_in phosphatidylinositol 3-kinase signaling 7556068 Process
2064 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 12000754 Process
2064 GO:0030307 IMP involved_in positive regulation of cell growth 21555369 Process
2064 GO:0032886 IDA involved_in regulation of microtubule-based process 20937854 Process
2064 GO:0035556 IDA involved_in intracellular signal transduction 19372587 Process
2064 GO:0038134 IDA involved_in ERBB2-EGFR signaling pathway 8702723 Process
2064 GO:0042060 IDA involved_in wound healing 12646923 Process
2064 GO:0043406 IDA involved_in positive regulation of MAP kinase activity 10572067 Process
2064 GO:0045727 IMP involved_in positive regulation of translation 21555369 Process
2064 GO:0045785 IDA involved_in positive regulation of cell adhesion 7556068 Process
2064 GO:0045943 IMP involved_in positive regulation of transcription by RNA polymerase I 21555369 Process
2064 GO:0046777 IDA involved_in protein autophosphorylation 7556068 Process
2064 GO:0050679 IDA involved_in positive regulation of epithelial cell proliferation 10572067 Process
2064 GO:0070372 IMP involved_in regulation of ERK1 and ERK2 cascade 16314522 Process
2064 GO:0071363 IDA involved_in cellular response to growth factor stimulus 20010870 Process
2064 GO:0071364 IMP involved_in cellular response to epidermal growth factor stimulus 27134172 Process
2064 GO:0090314 IDA involved_in positive regulation of protein targeting to membrane 20010870 Process