Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 2066
  • Symbol: ERBB4
  • Description: erb-b2 receptor tyrosine kinase 4

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2066 GO:0000976 IMP enables transcription cis-regulatory region binding 15534001 Function
2066 GO:0004713 IDA enables protein tyrosine kinase activity 18334220 Function
2066 GO:0004714 IDA enables transmembrane receptor protein tyrosine kinase activity 18334220 Function
2066 GO:0005154 IPI enables epidermal growth factor receptor binding 8617750 Function
2066 GO:0005515 IPI enables protein binding 9135143,9419975,10572067,10725395,11867753,15282549,15345710,1..... Function
2066 GO:0038131 IDA enables neuregulin receptor activity 9275162,12466964 Function
2066 GO:0042803 IPI enables protein homodimerization activity 18334220 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2066 GO:0005634 IDA located_in nucleus 15534001 Component
2066 GO:0005739 IDA located_in mitochondrion 16778220 Component
2066 GO:0005886 IDA is_active_in plasma membrane 9275162,12466964 Component
2066 GO:0016323 IDA located_in basolateral plasma membrane 12646923 Component
2066 GO:0043235 IDA part_of receptor complex 23382219 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2066 GO:0007165 IDA involved_in signal transduction 10572067 Process
2066 GO:0007169 IDA involved_in transmembrane receptor protein tyrosine kinase signaling pathway 10353604,18334220 Process
2066 GO:0007595 IMP involved_in lactation 15534001 Process
2066 GO:0008284 IMP involved_in positive regulation of cell population proliferation 8617750,9135143 Process
2066 GO:0008285 IMP involved_in negative regulation of cell population proliferation 17120616 Process
2066 GO:0016477 IDA involved_in cell migration 9135143 Process
2066 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 18334220 Process
2066 GO:0038130 IDA involved_in ERBB4 signaling pathway 9275162,12466964 Process
2066 GO:0038138 IDA involved_in ERBB4-ERBB4 signaling pathway 9275162,12466964 Process
2066 GO:0042531 IMP involved_in positive regulation of tyrosine phosphorylation of STAT protein 16837552 Process
2066 GO:0043653 IMP involved_in mitochondrial fragmentation involved in apoptotic process 16778220 Process
2066 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 15534001 Process
2066 GO:0046427 IMP involved_in positive regulation of receptor signaling pathway via JAK-STAT 15534001 Process
2066 GO:0046777 IDA involved_in protein autophosphorylation 18334220 Process
2066 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 10348342 Process