Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 21385
  • Symbol: Tbx2
  • Description: T-box 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
21385 GO:0000122 IDA acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II 12023302,15042700 Process
21385 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 9710594,11867218,18025091 Process
21385 GO:0000122 IGI acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II 18285513 Process
21385 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 26971330,27720610,28910203,33795231 Process
21385 GO:0003007 IMP acts_upstream_of_or_within heart morphogenesis 15459098 Process
21385 GO:0003148 IMP involved_in outflow tract septum morphogenesis 15459098 Process
21385 GO:0003151 IMP involved_in outflow tract morphogenesis 15042700,15459098,22186728 Process
21385 GO:0003203 IMP involved_in endocardial cushion morphogenesis 15459098 Process
21385 GO:0006357 IDA involved_in regulation of transcription by RNA polymerase II 15459098 Process
21385 GO:0006915 IMP involved_in apoptotic process 33795231 Process
21385 GO:0007219 IDA acts_upstream_of_or_within Notch signaling pathway 23117660 Process
21385 GO:0007521 IMP acts_upstream_of_or_within muscle cell fate determination 15459098 Process
21385 GO:0008543 IMP involved_in fibroblast growth factor receptor signaling pathway 33795231 Process
21385 GO:0022008 IMP involved_in neurogenesis 33795231 Process
21385 GO:0032526 IDA involved_in response to retinoic acid 22186728 Process
21385 GO:0035909 IMP involved_in aorta morphogenesis 15459098 Process
21385 GO:0036302 IGI involved_in atrioventricular canal development 22130515 Process
21385 GO:0036302 IMP involved_in atrioventricular canal development 15459098 Process
21385 GO:0042733 IMP involved_in embryonic digit morphogenesis 15459098 Process
21385 GO:0043474 IMP acts_upstream_of_negative_effect pigment metabolic process involved in pigmentation 26971330 Process
21385 GO:0045892 IDA acts_upstream_of_or_within negative regulation of DNA-templated transcription 11748239,15843407 Process
21385 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 22186728 Process
21385 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 11867218,26486273 Process
21385 GO:0048596 IMP involved_in embryonic camera-type eye morphogenesis 15459098 Process
21385 GO:0048738 IMP acts_upstream_of_or_within cardiac muscle tissue development 15459098 Process
21385 GO:0051145 IGI acts_upstream_of_or_within smooth muscle cell differentiation 30478225 Process
21385 GO:0060021 IGI acts_upstream_of_or_within roof of mouth development 19769959 Process
21385 GO:0060021 IMP acts_upstream_of_or_within roof of mouth development 19769959 Process
21385 GO:0060045 IMP involved_in positive regulation of cardiac muscle cell proliferation 15042700 Process
21385 GO:0060379 IDA involved_in cardiac muscle cell myoblast differentiation 15459098 Process
21385 GO:0060441 IGI involved_in epithelial tube branching involved in lung morphogenesis 27720610 Process
21385 GO:0060465 IMP involved_in pharynx development 15459098 Process
21385 GO:0060560 IMP acts_upstream_of_or_within developmental growth involved in morphogenesis 19769959 Process
21385 GO:0060596 IGI acts_upstream_of_or_within mammary placode formation 16222716 Process
21385 GO:0060916 IMP involved_in mesenchymal cell proliferation involved in lung development 27720610 Process
21385 GO:0072105 IGI acts_upstream_of_or_within ureteric peristalsis 30478225 Process
21385 GO:0090103 IMP involved_in cochlea morphogenesis 33795231 Process
21385 GO:0090398 IDA acts_upstream_of_or_within cellular senescence 11748239 Process
21385 GO:0097325 IMP involved_in melanocyte proliferation 26486273 Process
21385 GO:1901208 IMP involved_in negative regulation of heart looping 15042700 Process
21385 GO:1901211 IMP involved_in negative regulation of cardiac chamber formation 15042700 Process
21385 GO:1902808 IMP involved_in positive regulation of cell cycle G1/S phase transition 26486273 Process
21385 GO:1905222 IGI involved_in atrioventricular canal morphogenesis 22130515 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
21385 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 9710594,11867218,18025091,22186728,27720610,33795231..... Function
21385 GO:0000978 IMP enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 26486273,26971330,28910203 Function
21385 GO:0003677 IDA enables DNA binding 15843407 Function
21385 GO:0003700 IDA enables DNA-binding transcription factor activity 15843407 Function
21385 GO:0005515 IPI enables protein binding 12023302,33795231 Function
21385 GO:0042826 IPI enables histone deacetylase binding 33795231 Function
21385 GO:0140297 IPI enables DNA-binding transcription factor binding 33795231 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
21385 GO:0005634 IDA located_in nucleus 15042700,18025091,26486273,26971330,28910203 Component
21385 GO:0005667 IDA part_of transcription regulator complex 12023302 Component
21385 GO:0005667 IPI part_of transcription regulator complex 18285513 Component
21385 GO:0005737 IDA located_in cytoplasm 18025091 Component