Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 22040
  • Symbol: Trex1
  • Description: three prime repair exonuclease 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22040 GO:0000077 IMP acts_upstream_of_or_within DNA damage checkpoint signaling 18045533 Process
22040 GO:0001568 IMP acts_upstream_of_or_within blood vessel development 25848017 Process
22040 GO:0001822 IMP acts_upstream_of_or_within kidney development 25848017 Process
22040 GO:0002250 IMP acts_upstream_of_or_within adaptive immune response 25848017 Process
22040 GO:0002251 IMP acts_upstream_of_or_within organ or tissue specific immune response 24218451 Process
22040 GO:0002253 IMP acts_upstream_of_or_within activation of immune response 18045533 Process
22040 GO:0002281 IMP acts_upstream_of_or_within macrophage activation involved in immune response 24218451 Process
22040 GO:0002320 IMP acts_upstream_of_or_within lymphoid progenitor cell differentiation 25848017 Process
22040 GO:0002381 IMP acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response 25848017 Process
22040 GO:0002383 IMP acts_upstream_of_or_within immune response in brain or nervous system 24218451 Process
22040 GO:0002437 IMP acts_upstream_of_or_within inflammatory response to antigenic stimulus 24218451 Process
22040 GO:0002457 IMP acts_upstream_of_or_within T cell antigen processing and presentation 24218451 Process
22040 GO:0002637 IGI acts_upstream_of_or_within regulation of immunoglobulin production 26371324 Process
22040 GO:0002637 IMP acts_upstream_of_or_within regulation of immunoglobulin production 26320659 Process
22040 GO:0003007 IMP acts_upstream_of_or_within heart morphogenesis 15254239 Process
22040 GO:0003015 IMP acts_upstream_of_or_within heart process 15254239 Process
22040 GO:0003228 IMP acts_upstream_of_or_within atrial cardiac muscle tissue development 15254239 Process
22040 GO:0006091 IMP acts_upstream_of_or_within generation of precursor metabolites and energy 28069950 Process
22040 GO:0006110 IMP acts_upstream_of_or_within regulation of glycolytic process 28069950 Process
22040 GO:0006259 IDA involved_in DNA metabolic process 11279105 Process
22040 GO:0006260 IMP acts_upstream_of_or_within DNA replication 20511593 Process
22040 GO:0006304 IMP acts_upstream_of_or_within DNA modification 24205360 Process
22040 GO:0006308 IDA acts_upstream_of_or_within DNA catabolic process 20871604 Process
22040 GO:0006308 IMP acts_upstream_of_or_within DNA catabolic process 18724932,19923437,23993650,25848017 Process
22040 GO:0006954 IMP acts_upstream_of_or_within inflammatory response 15254239,25848017,28351661 Process
22040 GO:0006955 IMP acts_upstream_of_or_within immune response 28835460 Process
22040 GO:0006974 IDA acts_upstream_of_or_within DNA damage response 20511593 Process
22040 GO:0008340 IGI acts_upstream_of_or_within determination of adult lifespan 26371324,28069950 Process
22040 GO:0008340 IMP acts_upstream_of_or_within determination of adult lifespan 15254239 Process
22040 GO:0009411 IMP acts_upstream_of_or_within response to UV 28351661 Process
22040 GO:0010468 IGI acts_upstream_of_or_within regulation of gene expression 23160154 Process
22040 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 23160154 Process
22040 GO:0019217 IMP acts_upstream_of_or_within regulation of fatty acid metabolic process 28069950 Process
22040 GO:0031323 IGI acts_upstream_of_or_within regulation of cellular metabolic process 28069950 Process
22040 GO:0031323 IMP acts_upstream_of_or_within regulation of cellular metabolic process 28069950 Process
22040 GO:0031571 IMP acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling 18045533,23993650 Process
22040 GO:0032197 IMP acts_upstream_of_or_within retrotransposition 28835460 Process
22040 GO:0032479 IGI acts_upstream_of_or_within regulation of type I interferon production 26371324 Process
22040 GO:0032479 IMP acts_upstream_of_or_within regulation of type I interferon production 20871604,24154727 Process
22040 GO:0032508 IDA acts_upstream_of_or_within DNA duplex unwinding 25848017 Process
22040 GO:0032607 IMP acts_upstream_of_or_within interferon-alpha production 24218451 Process
22040 GO:0032680 IMP acts_upstream_of_or_within regulation of tumor necrosis factor production 24218451 Process
22040 GO:0034599 IMP acts_upstream_of_or_within cellular response to oxidative stress 23993650 Process
22040 GO:0034614 IMP acts_upstream_of_or_within cellular response to reactive oxygen species 23993650 Process
22040 GO:0034644 IDA acts_upstream_of_or_within cellular response to UV 20511593 Process
22040 GO:0035458 IDA acts_upstream_of_or_within cellular response to interferon-beta 19158679 Process
22040 GO:0035781 IMP acts_upstream_of_or_within CD86 biosynthetic process 24218451 Process
22040 GO:0043277 IMP acts_upstream_of_or_within apoptotic cell clearance 24218451 Process
22040 GO:0043457 IMP acts_upstream_of_or_within regulation of cellular respiration 28069950 Process
22040 GO:0045087 IMP acts_upstream_of_or_within innate immune response 23160154 Process
22040 GO:0045088 IMP acts_upstream_of_or_within regulation of innate immune response 20871604,26320659 Process
22040 GO:0045184 IMP acts_upstream_of_or_within establishment of protein localization 23160154 Process
22040 GO:0046890 IGI acts_upstream_of_or_within regulation of lipid biosynthetic process 28069950 Process
22040 GO:0050727 IGI acts_upstream_of_or_within regulation of inflammatory response 28069950 Process
22040 GO:0050790 IMP acts_upstream_of_or_within regulation of catalytic activity 23160154 Process
22040 GO:0050821 IDA acts_upstream_of_or_within protein stabilization 26320659 Process
22040 GO:0050863 IGI acts_upstream_of_or_within regulation of T cell activation 26371324 Process
22040 GO:0051319 IMP acts_upstream_of_or_within G2 phase 18045533 Process
22040 GO:0051607 IMP acts_upstream_of_or_within defense response to virus 20871604,23160154 Process
22040 GO:0060337 IMP acts_upstream_of_or_within type I interferon-mediated signaling pathway 28351661 Process
22040 GO:0060339 IMP acts_upstream_of_or_within negative regulation of type I interferon-mediated signaling pathway 18724932 Process
22040 GO:0061635 IMP acts_upstream_of_or_within regulation of protein complex stability 26320659 Process
22040 GO:0071310 IMP acts_upstream_of_or_within cellular response to organic substance 28351661 Process
22040 GO:0071357 IMP acts_upstream_of_or_within cellular response to type I interferon 28835460 Process
22040 GO:0071480 IMP acts_upstream_of_or_within cellular response to gamma radiation 18045533 Process
22040 GO:0072711 IMP acts_upstream_of_or_within cellular response to hydroxyurea 18045533 Process
22040 GO:0097281 IMP acts_upstream_of_or_within immune complex formation 25848017 Process
22040 GO:1904161 IMP acts_upstream_of_or_within DNA synthesis involved in UV-damage excision repair 23993650 Process
22040 GO:1905671 IMP acts_upstream_of_or_within regulation of lysosome organization 23160154 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22040 GO:0000287 IDA enables magnesium ion binding 25848017 Function
22040 GO:0003677 IDA enables DNA binding 20871604 Function
22040 GO:0003690 IDA enables double-stranded DNA binding 19158679,25848017 Function
22040 GO:0003697 IDA enables single-stranded DNA binding 17293595,17355961 Function
22040 GO:0005515 IPI enables protein binding 11279105,18724932 Function
22040 GO:0008296 IDA enables 3'-5'-DNA exonuclease activity 11279105 Function
22040 GO:0008301 IDA enables DNA binding, bending 25848017 Function
22040 GO:0008408 IMP enables 3'-5' exonuclease activity 15254239 Function
22040 GO:0032558 IDA enables adenyl deoxyribonucleotide binding 17293595 Function
22040 GO:0042802 IPI enables identical protein binding 17293595 Function
22040 GO:0042803 IPI enables protein homodimerization activity 11279105 Function
22040 GO:0050699 IDA enables WW domain binding 17355961 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22040 GO:0005634 IDA located_in nucleus 18045533,20511593 Component
22040 GO:0005737 IDA located_in cytoplasm 17355961,20511593 Component
22040 GO:0005783 IDA located_in endoplasmic reticulum 18724932,26320659 Component
22040 GO:0005829 IDA located_in cytosol 28351661 Component
22040 GO:0008250 IDA part_of oligosaccharyltransferase complex 26320659 Component
22040 GO:0032993 IDA part_of protein-DNA complex 25848017 Component
22040 GO:0043596 IDA located_in nuclear replication fork 18045533 Component