Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 22059
  • Symbol: Trp53
  • Description: transformation related protein 53

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22059 GO:0000122 IDA acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II 8183579 Process
22059 GO:0000122 IGI acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II 15657445,18212064,19411634 Process
22059 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 19749791 Process
22059 GO:0000423 IMP acts_upstream_of mitophagy 22044588 Process
22059 GO:0001701 IGI NOT acts_upstream_of_or_within in utero embryonic development 9425892 Process
22059 GO:0001701 IGI acts_upstream_of_or_within in utero embryonic development 9288110,17325035 Process
22059 GO:0001756 IGI acts_upstream_of_or_within somitogenesis 17320900 Process
22059 GO:0001836 IDA acts_upstream_of_or_within release of cytochrome c from mitochondria 15483136 Process
22059 GO:0001836 IGI acts_upstream_of_or_within release of cytochrome c from mitochondria 14963330 Process
22059 GO:0002309 IGI acts_upstream_of_or_within T cell proliferation involved in immune response 16357222 Process
22059 GO:0002326 IMP acts_upstream_of_or_within B cell lineage commitment 8788039 Process
22059 GO:0002360 IMP acts_upstream_of_or_within T cell lineage commitment 8788039 Process
22059 GO:0002931 IMP acts_upstream_of_or_within response to ischemia 22044588 Process
22059 GO:0006302 IMP acts_upstream_of_or_within double-strand break repair 17912366 Process
22059 GO:0006355 IDA acts_upstream_of_or_within regulation of DNA-templated transcription 12135983 Process
22059 GO:0006357 IDA acts_upstream_of_or_within regulation of transcription by RNA polymerase II 24013501 Process
22059 GO:0006606 IDA acts_upstream_of_or_within protein import into nucleus 11799106 Process
22059 GO:0006915 IDA acts_upstream_of_or_within apoptotic process 16183742 Process
22059 GO:0006915 IGI acts_upstream_of_or_within apoptotic process 17325035 Process
22059 GO:0006915 IMP acts_upstream_of apoptotic process 17912366 Process
22059 GO:0006915 IMP involved_in apoptotic process 17434459 Process
22059 GO:0006974 IDA acts_upstream_of_or_within DNA damage response 14744935,15383658 Process
22059 GO:0006974 IMP acts_upstream_of_or_within DNA damage response 11092819,12952892,17591690 Process
22059 GO:0006977 IGI acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 16107883 Process
22059 GO:0006978 IDA acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 10710310 Process
22059 GO:0006979 IGI acts_upstream_of_or_within response to oxidative stress 22726440 Process
22059 GO:0006979 IMP acts_upstream_of_or_within response to oxidative stress 17591690 Process
22059 GO:0007179 IGI acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway 18212064 Process
22059 GO:0007346 IDA acts_upstream_of_or_within regulation of mitotic cell cycle 17515607 Process
22059 GO:0007369 IGI acts_upstream_of_or_within gastrulation 17000767 Process
22059 GO:0007405 IGI acts_upstream_of neuroblast proliferation 9608530 Process
22059 GO:0007406 IGI acts_upstream_of_or_within negative regulation of neuroblast proliferation 9608530 Process
22059 GO:0007417 IGI acts_upstream_of_or_within central nervous system development 16199867 Process
22059 GO:0007507 IGI acts_upstream_of_or_within heart development 22821713 Process
22059 GO:0007623 IEP involved_in circadian rhythm 24051492 Process
22059 GO:0008156 IDA acts_upstream_of_or_within negative regulation of DNA replication 11884608 Process
22059 GO:0008156 IMP acts_upstream_of_or_within negative regulation of DNA replication 11884608 Process
22059 GO:0008283 IGI acts_upstream_of cell population proliferation 10973261 Process
22059 GO:0008285 IGI acts_upstream_of_or_within negative regulation of cell population proliferation 10591652,23935987 Process
22059 GO:0008285 IMP involved_in negative regulation of cell population proliferation 19749791 Process
22059 GO:0008340 IMP involved_in determination of adult lifespan 20818388 Process
22059 GO:0009303 IGI acts_upstream_of_or_within rRNA transcription 18809582 Process
22059 GO:0009410 IDA acts_upstream_of_or_within response to xenobiotic stimulus 9098922 Process
22059 GO:0009411 IDA acts_upstream_of_or_within response to UV 14744935 Process
22059 GO:0009411 IMP acts_upstream_of_or_within response to UV 10815637,11092819,12952892 Process
22059 GO:0009651 IGI acts_upstream_of_or_within response to salt stress 16571598 Process
22059 GO:0009792 IGI acts_upstream_of_or_within embryo development ending in birth or egg hatching 16702401 Process
22059 GO:0010035 IMP involved_in response to inorganic substance 17434459 Process
22059 GO:0010165 IDA acts_upstream_of_or_within response to X-ray 11884608 Process
22059 GO:0010165 IMP acts_upstream_of_or_within response to X-ray 22821713 Process
22059 GO:0010332 IDA acts_upstream_of_or_within response to gamma radiation 14744935 Process
22059 GO:0010332 IMP acts_upstream_of_or_within response to gamma radiation 17068116 Process
22059 GO:0010629 IGI acts_upstream_of_or_within negative regulation of gene expression 18625840 Process
22059 GO:0010659 IMP acts_upstream_of cardiac muscle cell apoptotic process 22044588 Process
22059 GO:0010666 IMP acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process 22044588 Process
22059 GO:0014009 IGI acts_upstream_of glial cell proliferation 10973261,11246230 Process
22059 GO:0019661 IMP acts_upstream_of glucose catabolic process to lactate via pyruvate 20935145 Process
22059 GO:0021549 IDA acts_upstream_of_or_within cerebellum development 24013501 Process
22059 GO:0030330 IDA acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator 11790307,11884608 Process
22059 GO:0030330 IGI acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator 16199867,17476307 Process
22059 GO:0030512 IMP acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway 15657445 Process
22059 GO:0031571 IMP acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling 16107883 Process
22059 GO:0033077 IGI acts_upstream_of_or_within T cell differentiation in thymus 16357222 Process
22059 GO:0033554 IGI acts_upstream_of_or_within cellular response to stress 26158450 Process
22059 GO:0034103 IMP acts_upstream_of_or_within regulation of tissue remodeling 22044588 Process
22059 GO:0034644 IDA involved_in cellular response to UV 23629966 Process
22059 GO:0034644 IGI acts_upstream_of_or_within cellular response to UV 14963330 Process
22059 GO:0035264 IGI acts_upstream_of_or_within multicellular organism growth 17116431,17325035 Process
22059 GO:0035794 IGI acts_upstream_of_or_within positive regulation of mitochondrial membrane permeability 22726440 Process
22059 GO:0036003 IDA involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress 22262176 Process
22059 GO:0042127 IGI acts_upstream_of_or_within regulation of cell population proliferation 10716720,10805805 Process
22059 GO:0042127 IMP acts_upstream_of_or_within regulation of cell population proliferation 12878730 Process
22059 GO:0042771 IDA involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 16213212 Process
22059 GO:0042771 IGI acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 15983387,16286009,17476307 Process
22059 GO:0042771 IMP acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12135983,12952892,16777961 Process
22059 GO:0042771 IMP involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 20818388 Process
22059 GO:0043065 IGI acts_upstream_of_or_within positive regulation of apoptotic process 9024662,16571598 Process
22059 GO:0043065 IMP acts_upstream_of_or_within positive regulation of apoptotic process 17068116 Process
22059 GO:0043066 IMP acts_upstream_of_or_within negative regulation of apoptotic process 8183579,17912366 Process
22059 GO:0043153 IMP involved_in entrainment of circadian clock by photoperiod 24051492 Process
22059 GO:0043504 IMP acts_upstream_of_or_within mitochondrial DNA repair 24101517 Process
22059 GO:0043516 IGI acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator 21522133 Process
22059 GO:0043523 IGI acts_upstream_of_or_within regulation of neuron apoptotic process 15483136 Process
22059 GO:0043525 IDA acts_upstream_of_or_within positive regulation of neuron apoptotic process 10894779 Process
22059 GO:0043525 IGI acts_upstream_of_or_within positive regulation of neuron apoptotic process 10911993,16777961 Process
22059 GO:0043525 IMP acts_upstream_of_or_within positive regulation of neuron apoptotic process 9608530,11092819,11150333,15483136 Process
22059 GO:0045861 IMP acts_upstream_of_or_within negative regulation of proteolysis 23277542 Process
22059 GO:0045892 IDA involved_in negative regulation of DNA-templated transcription 24051492 Process
22059 GO:0045892 IMP involved_in negative regulation of DNA-templated transcription 19749791,23629966 Process
22059 GO:0045893 IDA acts_upstream_of_or_within positive regulation of DNA-templated transcription 15735665,16044147 Process
22059 GO:0045893 IGI acts_upstream_of_or_within positive regulation of DNA-templated transcription 15735665 Process
22059 GO:0045930 IGI acts_upstream_of_or_within negative regulation of mitotic cell cycle 8612582 Process
22059 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 7677753,8183579,16098148,16107883,19411634,20368352,21159655..... Process
22059 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 22362889 Process
22059 GO:0045944 IMP acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 20434500,21159655 Process
22059 GO:0048144 IGI acts_upstream_of fibroblast proliferation 16107883 Process
22059 GO:0048144 IMP acts_upstream_of fibroblast proliferation 17332504 Process
22059 GO:0048147 IGI acts_upstream_of_or_within negative regulation of fibroblast proliferation 16107883 Process
22059 GO:0048147 IMP acts_upstream_of_or_within negative regulation of fibroblast proliferation 12952892,17332504 Process
22059 GO:0048512 IMP involved_in circadian behavior 24051492 Process
22059 GO:0048568 IGI acts_upstream_of_or_within embryonic organ development 17470788 Process
22059 GO:0050731 IMP involved_in positive regulation of peptidyl-tyrosine phosphorylation 19749791 Process
22059 GO:0050821 IGI acts_upstream_of_or_within protein stabilization 18625840 Process
22059 GO:0051276 IGI acts_upstream_of_or_within chromosome organization 17053789,17200209 Process
22059 GO:0051402 IGI acts_upstream_of neuron apoptotic process 10911993 Process
22059 GO:0051402 IGI acts_upstream_of_or_within neuron apoptotic process 15485914 Process
22059 GO:0051402 IMP acts_upstream_of neuron apoptotic process 9608530,11092819,11150333 Process
22059 GO:0051402 IMP acts_upstream_of_or_within neuron apoptotic process 17591690 Process
22059 GO:0051726 IGI acts_upstream_of_or_within regulation of cell cycle 18332125 Process
22059 GO:0051726 IMP acts_upstream_of_or_within regulation of cell cycle 15898111 Process
22059 GO:0060253 IGI acts_upstream_of_or_within negative regulation of glial cell proliferation 10973261,11246230 Process
22059 GO:0060333 IMP involved_in type II interferon-mediated signaling pathway 23629966 Process
22059 GO:0060411 IGI acts_upstream_of_or_within cardiac septum morphogenesis 22821713 Process
22059 GO:0061419 IMP acts_upstream_of_or_within positive regulation of transcription from RNA polymerase II promoter in response to hypoxia 20935145 Process
22059 GO:0062100 IMP involved_in positive regulation of programmed necrotic cell death 27258785 Process
22059 GO:0070059 IMP involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 16407291 Process
22059 GO:0070242 IMP acts_upstream_of thymocyte apoptotic process 17210642 Process
22059 GO:0070243 IGI acts_upstream_of_or_within regulation of thymocyte apoptotic process 17210642 Process
22059 GO:0070245 IMP acts_upstream_of_or_within positive regulation of thymocyte apoptotic process 17210642 Process
22059 GO:0070245 IMP involved_in positive regulation of thymocyte apoptotic process 20818388 Process
22059 GO:0070266 IGI acts_upstream_of_or_within necroptotic process 22726440 Process
22059 GO:0071479 IDA involved_in cellular response to ionizing radiation 16213212 Process
22059 GO:0071479 IGI acts_upstream_of_or_within cellular response to ionizing radiation 16286009 Process
22059 GO:0071480 IDA acts_upstream_of_or_within cellular response to gamma radiation 10710310 Process
22059 GO:0071494 IGI acts_upstream_of_or_within cellular response to UV-C 24014029 Process
22059 GO:0072089 IGI acts_upstream_of stem cell proliferation 10591653 Process
22059 GO:0072332 IDA acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator 12135983,16107883 Process
22059 GO:0072332 IDA involved_in intrinsic apoptotic signaling pathway by p53 class mediator 22262176 Process
22059 GO:0072332 IGI acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator 20434500 Process
22059 GO:0072593 IMP acts_upstream_of reactive oxygen species metabolic process 22044588 Process
22059 GO:1901525 IMP acts_upstream_of_or_within negative regulation of mitophagy 22044588 Process
22059 GO:1902108 IGI acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process 14963330 Process
22059 GO:1902253 IMP acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator 17571083 Process
22059 GO:1903799 IGI acts_upstream_of_or_within negative regulation of miRNA processing 21522133 Process
22059 GO:1904024 IMP acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate 20935145 Process
22059 GO:1990144 IMP acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to hypoxia 20935145 Process
22059 GO:1990440 IMP involved_in positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 16407291 Process
22059 GO:2000269 IGI acts_upstream_of_or_within regulation of fibroblast apoptotic process 17116431 Process
22059 GO:2000378 IMP acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process 22044588 Process
22059 GO:2000647 IGI acts_upstream_of_or_within negative regulation of stem cell proliferation 10591653 Process
22059 GO:2000772 IGI acts_upstream_of_or_within regulation of cellular senescence 22904064 Process
22059 GO:2000774 IGI acts_upstream_of_or_within positive regulation of cellular senescence 17053789 Process
22059 GO:2000774 IMP involved_in positive regulation of cellular senescence 10562313 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22059 GO:0000977 IDA enables RNA polymerase II transcription regulatory region sequence-specific DNA binding 22897442 Function
22059 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 10205143,12135983,16107883,16363065,21159655,22737085,24013501..... Function
22059 GO:0001228 IDA enables DNA-binding transcription activator activity, RNA polymerase II-specific 21159655,21300779 Function
22059 GO:0001228 IGI enables DNA-binding transcription activator activity, RNA polymerase II-specific 16286009 Function
22059 GO:0003682 IDA enables chromatin binding 15657445,18212064,20434500 Function
22059 GO:0003700 IDA enables DNA-binding transcription factor activity 12135983,16044147,16098148 Function
22059 GO:0005515 IPI enables protein binding 9194565,10205143,10329544,10329696,10894779,11181729,11274052,..... Function
22059 GO:0031625 IPI enables ubiquitin protein ligase binding 24240685 Function
22059 GO:0035033 IDA enables histone deacetylase regulator activity 15657445 Function
22059 GO:0097371 IPI enables MDM2/MDM4 family protein binding 20818388 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22059 GO:0005634 IDA located_in nucleus 11799106,11900485,14729462,15532030,16407291,17591690,18332125..... Component
22059 GO:0005657 IDA located_in replication fork 15364958 Component
22059 GO:0005737 IDA located_in cytoplasm 11799106,11900485,12524542 Component
22059 GO:0005739 IDA located_in mitochondrion 12667443 Component
22059 GO:0005759 IDA located_in mitochondrial matrix 22726440 Component
22059 GO:0005829 IDA located_in cytosol 11799106 Component
22059 GO:0035861 IDA located_in site of double-strand break 24550317 Component
22059 GO:0043073 IDA located_in germ cell nucleus 12524542 Component