Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 22084
  • Symbol: Tsc2
  • Description: TSC complex subunit 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22084 GO:0001666 IMP acts_upstream_of_or_within response to hypoxia 18198340 Process
22084 GO:0001843 IMP acts_upstream_of_or_within neural tube closure 10096549 Process
22084 GO:0006366 IMP acts_upstream_of transcription by RNA polymerase II 23858058 Process
22084 GO:0006469 IMP acts_upstream_of_or_within negative regulation of protein kinase activity 15249583 Process
22084 GO:0006606 IMP acts_upstream_of_or_within protein import into nucleus 10827137 Process
22084 GO:0007507 IMP acts_upstream_of_or_within heart development 10096549 Process
22084 GO:0008104 IDA acts_upstream_of_or_within protein localization 11741832 Process
22084 GO:0008283 IGI acts_upstream_of cell population proliferation 16027168,16027169 Process
22084 GO:0008283 IMP acts_upstream_of cell population proliferation 10096549,10491404 Process
22084 GO:0008285 IGI acts_upstream_of_or_within negative regulation of cell population proliferation 16027168 Process
22084 GO:0008285 IMP acts_upstream_of_or_within negative regulation of cell population proliferation 10096549,10491404,10827137 Process
22084 GO:0010508 IMP involved_in positive regulation of autophagy 23878245 Process
22084 GO:0014065 IMP acts_upstream_of phosphatidylinositol 3-kinase signaling 16027169 Process
22084 GO:0014065 IMP acts_upstream_of_or_within phosphatidylinositol 3-kinase signaling 15249583 Process
22084 GO:0014067 IMP acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase signaling 16027169 Process
22084 GO:0016239 IMP acts_upstream_of_or_within positive regulation of macroautophagy 20453062 Process
22084 GO:0016239 IMP involved_in positive regulation of macroautophagy 23778976 Process
22084 GO:0030100 IMP acts_upstream_of_or_within regulation of endocytosis 10827137 Process
22084 GO:0030889 IGI acts_upstream_of_or_within negative regulation of B cell proliferation 16027169 Process
22084 GO:0032007 IGI involved_in negative regulation of TOR signaling 23778976 Process
22084 GO:0032007 IMP acts_upstream_of_or_within negative regulation of TOR signaling 18198340 Process
22084 GO:0032869 IMP acts_upstream_of_or_within cellular response to insulin stimulus 18511518 Process
22084 GO:0042098 IGI acts_upstream_of T cell proliferation 16027169 Process
22084 GO:0042100 IGI acts_upstream_of B cell proliferation 16027169 Process
22084 GO:0042130 IGI acts_upstream_of_or_within negative regulation of T cell proliferation 16027169 Process
22084 GO:0043276 IMP involved_in anoikis 23778976 Process
22084 GO:0043491 IGI acts_upstream_of protein kinase B signaling 16027169 Process
22084 GO:0043491 IGI acts_upstream_of_or_within protein kinase B signaling 15249583 Process
22084 GO:0043491 IMP acts_upstream_of protein kinase B signaling 16027169 Process
22084 GO:0043491 IMP acts_upstream_of_or_within protein kinase B signaling 15249583 Process
22084 GO:0044861 IMP acts_upstream_of_or_within protein transport into plasma membrane raft 18511518 Process
22084 GO:0045944 IMP acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 23858058 Process
22084 GO:0046323 IMP acts_upstream_of_or_within glucose import 18511518 Process
22084 GO:0046626 IMP acts_upstream_of_or_within regulation of insulin receptor signaling pathway 12403809 Process
22084 GO:0048009 IGI acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway 15249583 Process
22084 GO:0048009 IMP acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway 15249583 Process
22084 GO:0050918 IMP acts_upstream_of_or_within positive chemotaxis 15249583 Process
22084 GO:0051898 IGI acts_upstream_of_or_within negative regulation of protein kinase B signaling 16027169 Process
22084 GO:0051898 IMP acts_upstream_of_or_within negative regulation of protein kinase B signaling 16027169 Process
22084 GO:0098976 IMP involved_in excitatory chemical synaptic transmission 30679017 Process
22084 GO:0098977 IMP involved_in inhibitory chemical synaptic transmission 30679017 Process
22084 GO:1904262 IMP involved_in negative regulation of TORC1 signaling 23878245 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22084 GO:0005515 IPI enables protein binding 11741832,18692468,20412061,28671696 Function
22084 GO:0071889 IDA enables 14-3-3 protein binding 18198340 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22084 GO:0005737 IDA located_in cytoplasm 11741832 Component
22084 GO:0045202 EXP is_active_in synapse 16452087,25211037 Component
22084 GO:0045202 IDA is_active_in synapse 16452087,25211037 Component