Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 2332
  • Symbol: FMR1
  • Description: fragile X messenger ribonucleoprotein 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2332 GO:0000381 IDA involved_in regulation of alternative mRNA splicing, via spliceosome 18653529 Process
2332 GO:0002092 IDA involved_in positive regulation of receptor internalization 25561520 Process
2332 GO:0006281 IDA involved_in DNA repair 24813610 Process
2332 GO:0006406 IDA involved_in mRNA export from nucleus 31753916 Process
2332 GO:0017148 IDA involved_in negative regulation of translation 12417522,30765518,31439799 Process
2332 GO:0034063 IDA involved_in stress granule assembly 12417522 Process
2332 GO:0044830 IMP involved_in modulation by host of viral RNA genome replication 24514761 Process
2332 GO:0045727 IDA involved_in positive regulation of translation 19097999,19166269 Process
2332 GO:0051489 IDA involved_in regulation of filopodium assembly 16631377 Process
2332 GO:0060964 IMP involved_in regulation of miRNA-mediated gene silencing 25464849 Process
2332 GO:0060998 IDA involved_in regulation of dendritic spine development 16631377 Process
2332 GO:0098586 IDA involved_in cellular response to virus 24514761 Process
2332 GO:0098908 IDA involved_in regulation of neuronal action potential 25561520 Process
2332 GO:0140694 IDA involved_in non-membrane-bounded organelle assembly 30765518,31439799 Process
2332 GO:1901254 IMP involved_in positive regulation of intracellular transport of viral material 24514761 Process
2332 GO:1902373 IMP involved_in negative regulation of mRNA catabolic process 25225333 Process
2332 GO:1902416 IDA involved_in positive regulation of mRNA binding 25464849 Process
2332 GO:2000637 IDA involved_in positive regulation of miRNA-mediated gene silencing 17057366 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2332 GO:0002151 EXP enables G-quadruplex RNA binding 21642970,26374839 Function
2332 GO:0002151 IDA enables G-quadruplex RNA binding 18653529,25464849 Function
2332 GO:0003677 EXP enables DNA binding 10496225 Function
2332 GO:0003723 HDA enables RNA binding 22658674,22681889 Function
2332 GO:0003723 IDA enables RNA binding 15381419 Function
2332 GO:0003723 IMP enables RNA binding 10496225,25225333 Function
2332 GO:0003729 IDA enables mRNA binding 11157796,18936162,25561520,30765518,31439799 Function
2332 GO:0003730 IDA enables mRNA 3'-UTR binding 17417632 Function
2332 GO:0005515 IPI enables protein binding 7489725,10556305,11157796,11438699,12837692,15380484,15381419,..... Function
2332 GO:0008266 IDA enables poly(U) RNA binding 7688265,8156595 Function
2332 GO:0030371 IDA enables translation repressor activity 11157796 Function
2332 GO:0031369 IPI enables translation initiation factor binding 24658146 Function
2332 GO:0033592 IDA enables RNA strand annealing activity 17057366 Function
2332 GO:0034046 IDA enables poly(G) binding 7688265 Function
2332 GO:0035064 IDA enables methylated histone binding 24813610 Function
2332 GO:0035197 IDA enables siRNA binding 17057366 Function
2332 GO:0035198 IDA enables miRNA binding 17057366 Function
2332 GO:0035591 IDA enables signaling adaptor activity 31439799 Function
2332 GO:0035613 IDA enables RNA stem-loop binding 15805463,19166269 Function
2332 GO:0042802 IDA enables identical protein binding 11157796 Function
2332 GO:0042802 IPI enables identical protein binding 17850748,21446998,31413325 Function
2332 GO:0042803 IDA enables protein homodimerization activity 7489725 Function
2332 GO:0043022 IPI enables ribosome binding 24658146 Function
2332 GO:0044325 IPI enables transmembrane transporter binding 25561520 Function
2332 GO:0046982 IDA enables protein heterodimerization activity 7489725 Function
2332 GO:0048027 IDA enables mRNA 5'-UTR binding 19166269 Function
2332 GO:0140693 EXP enables molecular condensate scaffold activity 31439799 Function
2332 GO:0140693 IDA enables molecular condensate scaffold activity 30765518,31439799 Function
2332 GO:1990247 IDA enables N6-methyladenosine-containing RNA binding 31753916 Function
2332 GO:1990825 IDA enables sequence-specific mRNA binding 12927206,23235829 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2332 GO:0005634 IDA is_active_in nucleus 31753916 Component
2332 GO:0005634 IDA located_in nucleus 18936162 Component
2332 GO:0005654 IDA located_in nucleoplasm 16571602 Component
2332 GO:0005730 IDA located_in nucleolus 16571602,24658146 Component
2332 GO:0005737 IDA is_active_in cytoplasm 9259278 Component
2332 GO:0005737 IDA located_in cytoplasm 9659908,15381419,16571602,18936162 Component
2332 GO:0005829 IDA located_in cytosol Component
2332 GO:0005844 IDA part_of polysome 9659908,19097999,25464849,25561520 Component
2332 GO:0010494 IDA is_active_in cytoplasmic stress granule 12417522 Component
2332 GO:0016020 HDA located_in membrane 19946888 Component
2332 GO:0030426 IDA located_in growth cone 15380484 Component
2332 GO:0036464 IDA located_in cytoplasmic ribonucleoprotein granule 15121898,15380484,18093976 Component
2332 GO:0042995 IDA located_in cell projection 15380484 Component
2332 GO:0043005 IDA located_in neuron projection 18093976 Component
2332 GO:0043204 IDA located_in perikaryon 15380484,18093976 Component
2332 GO:0043232 IDA is_active_in intracellular non-membrane-bounded organelle 30765518,31439799 Component
2332 GO:0048471 IDA located_in perinuclear region of cytoplasm 24658146 Component
2332 GO:0071598 IDA is_active_in neuronal ribonucleoprotein granule 30765518 Component
2332 GO:1990124 IDA part_of messenger ribonucleoprotein complex 25225333 Component
2332 GO:1990904 IDA part_of ribonucleoprotein complex 9659908,19097999 Component