Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 23385
  • Symbol: NCSTN
  • Description: nicastrin

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23385 GO:0005515 IPI enables protein binding 12297508,15322109,15890777,16641999,18201567,19376115,26094765..... Function
23385 GO:0030674 IGI enables protein-macromolecule adaptor activity 12763021 Function
23385 GO:0030674 IMP enables protein-macromolecule adaptor activity 12297508 Function
23385 GO:0051117 IPI enables ATPase binding 26094765 Function
23385 GO:0070851 IPI enables growth factor receptor binding 26094765 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23385 GO:0005765 HDA located_in lysosomal membrane 17897319 Component
23385 GO:0005783 IDA located_in endoplasmic reticulum 15274632 Component
23385 GO:0005794 IDA located_in Golgi apparatus 15274632 Component
23385 GO:0005886 IDA located_in plasma membrane 15274632 Component
23385 GO:0005925 HDA located_in focal adhesion 21423176 Component
23385 GO:0016020 HDA located_in membrane 19946888 Component
23385 GO:0016020 IDA located_in membrane 25043039,26280335 Component
23385 GO:0070062 HDA located_in extracellular exosome 19056867,20458337 Component
23385 GO:0070765 IDA part_of gamma-secretase complex 12297508,25043039,26280335 Component
23385 GO:0070765 IGI part_of gamma-secretase complex 12763021 Component
23385 GO:0070765 IPI part_of gamma-secretase complex 26280335 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23385 GO:0006509 IDA involved_in membrane protein ectodomain proteolysis 15274632 Process
23385 GO:0007220 IDA involved_in Notch receptor processing 27608597 Process
23385 GO:0007220 IMP involved_in Notch receptor processing 12297508 Process
23385 GO:0010950 IGI involved_in positive regulation of endopeptidase activity 12763021 Process
23385 GO:0010950 IMP involved_in positive regulation of endopeptidase activity 12297508 Process
23385 GO:0016485 IDA involved_in protein processing 15274632,27608597 Process
23385 GO:0016485 IGI involved_in protein processing 12763021 Process
23385 GO:0016485 IMP involved_in protein processing 12297508 Process
23385 GO:0031293 IDA involved_in membrane protein intracellular domain proteolysis 15274632 Process
23385 GO:0034205 IDA involved_in amyloid-beta formation 27608597 Process
23385 GO:0034205 IGI involved_in amyloid-beta formation 12763021 Process
23385 GO:0034205 IMP involved_in amyloid-beta formation 12297508,25043039,26280335 Process
23385 GO:0042982 IDA involved_in amyloid precursor protein metabolic process 25043039,26280335 Process
23385 GO:0042987 IDA involved_in amyloid precursor protein catabolic process 15274632,27608597 Process
23385 GO:0042987 IGI involved_in amyloid precursor protein catabolic process 12763021 Process
23385 GO:0043085 IDA involved_in positive regulation of catalytic activity 15274632 Process