Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 23411
  • Symbol: SIRT1
  • Description: sirtuin 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23411 GO:0000012 IMP involved_in single strand break repair 20097625 Process
23411 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 12535671,15692560,20955178 Process
23411 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 21947282 Process
23411 GO:0000183 IDA involved_in rDNA heterochromatin formation 18485871 Process
23411 GO:0000183 IMP involved_in rDNA heterochromatin formation 18485871 Process
23411 GO:0000720 IMP involved_in pyrimidine dimer repair by nucleotide-excision repair 21149730 Process
23411 GO:0001525 IDA involved_in angiogenesis 20620956 Process
23411 GO:0001938 IMP involved_in positive regulation of endothelial cell proliferation 20203304 Process
23411 GO:0002821 IDA involved_in positive regulation of adaptive immune response 21890893 Process
23411 GO:0006325 IMP involved_in chromatin organization 22956909 Process
23411 GO:0006476 IDA involved_in protein deacetylation 18203716,18662546,20027304,20100829,20955178,31722219..... Process
23411 GO:0006476 IMP involved_in protein deacetylation 11672523,20424141,24824780 Process
23411 GO:0006974 IDA involved_in DNA damage response 18203716 Process
23411 GO:0006979 IDA involved_in response to oxidative stress 14976264 Process
23411 GO:0007179 IDA involved_in transforming growth factor beta receptor signaling pathway 23960241 Process
23411 GO:0007346 IDA involved_in regulation of mitotic cell cycle 15692560 Process
23411 GO:0008284 IMP involved_in positive regulation of cell population proliferation 21807113 Process
23411 GO:0010629 IMP involved_in negative regulation of gene expression 17916362,20203304 Process
23411 GO:0010824 IDA involved_in regulation of centrosome duplication 31722219 Process
23411 GO:0010868 IDA involved_in negative regulation of triglyceride biosynthetic process 29765047 Process
23411 GO:0016239 IDA involved_in positive regulation of macroautophagy 18296641 Process
23411 GO:0016567 IDA involved_in protein ubiquitination 21841822 Process
23411 GO:0016567 IMP involved_in protein ubiquitination 20203304 Process
23411 GO:0016575 IDA involved_in histone deacetylation 12006491,15469825 Process
23411 GO:0018394 IMP involved_in peptidyl-lysine acetylation 18004385 Process
23411 GO:0030308 IMP involved_in negative regulation of cell growth 17505061 Process
23411 GO:0031062 IMP involved_in positive regulation of histone methylation 18485871 Process
23411 GO:0031065 IMP involved_in positive regulation of histone deacetylation 18485871 Process
23411 GO:0031507 IDA involved_in heterochromatin formation 15469825 Process
23411 GO:0032007 IMP involved_in negative regulation of TOR signaling 20169165 Process
23411 GO:0032071 IMP involved_in regulation of endodeoxyribonuclease activity 19934257 Process
23411 GO:0032088 IDA involved_in negative regulation of NF-kappaB transcription factor activity 15152190 Process
23411 GO:0032922 IMP involved_in circadian regulation of gene expression 18662546 Process
23411 GO:0034983 IDA involved_in peptidyl-lysine deacetylation 15469825 Process
23411 GO:0042127 IMP involved_in regulation of cell population proliferation 12006491 Process
23411 GO:0042149 IMP involved_in cellular response to glucose starvation 18485871 Process
23411 GO:0042326 IMP involved_in negative regulation of phosphorylation 17612497 Process
23411 GO:0042542 IDA involved_in response to hydrogen peroxide 19934257 Process
23411 GO:0042771 IMP involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 20100829 Process
23411 GO:0042981 IMP involved_in regulation of apoptotic process 19934257 Process
23411 GO:0043065 IDA involved_in positive regulation of apoptotic process 15152190 Process
23411 GO:0043065 IMP involved_in positive regulation of apoptotic process 19047049 Process
23411 GO:0043066 IMP involved_in negative regulation of apoptotic process 16892051,21775285 Process
23411 GO:0043124 IDA involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling 17680780 Process
23411 GO:0043161 IMP involved_in proteasome-mediated ubiquitin-dependent protein catabolic process 21841822 Process
23411 GO:0043280 IMP involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 19047049 Process
23411 GO:0043433 IDA involved_in negative regulation of DNA-binding transcription factor activity 11672523,20955178 Process
23411 GO:0043433 IMP involved_in negative regulation of DNA-binding transcription factor activity 17505061 Process
23411 GO:0043518 IDA involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator 11672523 Process
23411 GO:0043536 IDA involved_in positive regulation of blood vessel endothelial cell migration 23960241 Process
23411 GO:0045348 IDA involved_in positive regulation of MHC class II biosynthetic process 21890893 Process
23411 GO:0045722 IDA involved_in positive regulation of gluconeogenesis 15692560,23142079,30193097 Process
23411 GO:0045739 IMP involved_in positive regulation of DNA repair 19934257 Process
23411 GO:0045766 IDA involved_in positive regulation of angiogenesis 23960241,25217442 Process
23411 GO:0045766 IMP involved_in positive regulation of angiogenesis 20424141,24048733 Process
23411 GO:0045786 IMP involved_in negative regulation of cell cycle 18485871 Process
23411 GO:0045892 IDA involved_in negative regulation of DNA-templated transcription 11672523,20074560 Process
23411 GO:0045892 IMP involved_in negative regulation of DNA-templated transcription 18485871 Process
23411 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 12837246,21807113 Process
23411 GO:0046015 IMP involved_in regulation of transcription by glucose 18485871 Process
23411 GO:0046628 IDA involved_in positive regulation of insulin receptor signaling pathway 21241768 Process
23411 GO:0051097 IDA involved_in negative regulation of helicase activity 18203716 Process
23411 GO:0051658 IDA involved_in maintenance of nucleus location 15692560 Process
23411 GO:0051898 IMP involved_in negative regulation of protein kinase B signaling 21149730 Process
23411 GO:0060766 IMP involved_in negative regulation of androgen receptor signaling pathway 17505061 Process
23411 GO:0070301 IDA involved_in cellular response to hydrogen peroxide 20027304 Process
23411 GO:0070914 IMP involved_in UV-damage excision repair 20670893 Process
23411 GO:0070932 IDA involved_in histone H3 deacetylation 20027304 Process
23411 GO:0070932 IMP involved_in histone H3 deacetylation 17505061 Process
23411 GO:0071356 IDA involved_in cellular response to tumor necrosis factor 15152190 Process
23411 GO:0071456 IMP involved_in cellular response to hypoxia 20620956 Process
23411 GO:0071900 IMP involved_in regulation of protein serine/threonine kinase activity 20203304 Process
23411 GO:0090400 IMP involved_in stress-induced premature senescence 17916362 Process
23411 GO:0097009 IMP involved_in energy homeostasis 18485871 Process
23411 GO:1901984 IMP involved_in negative regulation of protein acetylation 17916362,20203304 Process
23411 GO:1902176 IMP involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 17317627 Process
23411 GO:2000480 IDA involved_in negative regulation of cAMP-dependent protein kinase activity 20203304 Process
23411 GO:2000481 IMP involved_in positive regulation of cAMP-dependent protein kinase activity 18687677 Process
23411 GO:2000655 IMP involved_in negative regulation of cellular response to testosterone stimulus 17505061 Process
23411 GO:2000757 IDA involved_in negative regulation of peptidyl-lysine acetylation 20100829 Process
23411 GO:2000773 IDA involved_in negative regulation of cellular senescence 20203304 Process
23411 GO:2000773 IMP involved_in negative regulation of cellular senescence 20424141 Process
23411 GO:2000774 IDA involved_in positive regulation of cellular senescence 18687677 Process
23411 GO:2000781 IDA involved_in positive regulation of double-strand break repair 32538779 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23411 GO:0000785 IDA part_of chromatin 17505061,22956909 Component
23411 GO:0000791 IDA part_of euchromatin 15469825 Component
23411 GO:0000792 IDA part_of heterochromatin 15469825 Component
23411 GO:0001650 IDA located_in fibrillar center Component
23411 GO:0005634 IDA located_in nucleus 11672523,19934257,20027304,20167603,20955178 Component
23411 GO:0005635 IDA located_in nuclear envelope 15469825 Component
23411 GO:0005637 IDA located_in nuclear inner membrane 15469825 Component
23411 GO:0005654 IDA located_in nucleoplasm 16079181 Component
23411 GO:0005677 IDA part_of chromatin silencing complex 18485871 Component
23411 GO:0005730 IDA NOT located_in nucleolus 16079181 Component
23411 GO:0005730 IDA located_in nucleolus 15469825,18485871 Component
23411 GO:0005737 IDA NOT located_in cytoplasm 15469825 Component
23411 GO:0005737 IDA located_in cytoplasm 20027304 Component
23411 GO:0005739 IDA located_in mitochondrion Component
23411 GO:0005829 IDA is_active_in cytosol 20027304 Component
23411 GO:0005829 IDA located_in cytosol Component
23411 GO:0016605 IDA located_in PML body 12006491 Component
23411 GO:0033553 IDA part_of rDNA heterochromatin 18485871 Component
23411 GO:0061773 IPI part_of eNoSc complex 18485871 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23411 GO:0002039 IPI enables p53 binding 11672523 Function
23411 GO:0003714 IDA enables transcription corepressor activity 12535671 Function
23411 GO:0004407 EXP enables histone deacetylase activity 18485871 Function
23411 GO:0004407 IDA enables histone deacetylase activity 20027304 Function
23411 GO:0005515 IPI enables protein binding 11672523,12006491,12535671,14976264,15126506,15152190,15175761..... Function
23411 GO:0016922 IPI enables nuclear receptor binding 24043310 Function
23411 GO:0017136 IDA enables NAD-dependent histone deacetylase activity 12006491,15469825,16079181,16959573,28497810 Function
23411 GO:0019213 IDA enables deacetylase activity 18203716 Function
23411 GO:0019899 IPI enables enzyme binding 23382074 Function
23411 GO:0033558 IDA enables protein lysine deacetylase activity 19934257,20027304,21807113,23056314 Function
23411 GO:0033558 IMP enables protein lysine deacetylase activity 20424141,20670893 Function
23411 GO:0034979 IDA enables NAD-dependent protein deacetylase activity 15692560,20100829,20955178,21775285,23142079,29765047,30193097..... Function
23411 GO:0034979 IMP enables NAD-dependent protein deacetylase activity 11672523 Function
23411 GO:0042393 IPI enables histone binding 15469825,22956909 Function
23411 GO:0042802 IPI enables identical protein binding 15469825 Function
23411 GO:0043398 IPI enables HLH domain binding 12535671 Function
23411 GO:0043425 IPI enables bHLH transcription factor binding 12535671,21807113 Function
23411 GO:0051019 IPI enables mitogen-activated protein kinase binding 20027304 Function
23411 GO:0140297 IPI enables DNA-binding transcription factor binding 20955178,23382074 Function
23411 GO:0160012 IDA enables NAD-dependent histone decrotonylase activity 28497810 Function
23411 GO:1990254 IPI enables keratin filament binding 23382074 Function