Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 23621
  • Symbol: BACE1
  • Description: beta-secretase 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23621 GO:0001540 IPI enables amyloid-beta binding 16407538 Function
23621 GO:0004175 IDA enables endopeptidase activity 10677483 Function
23621 GO:0004190 IDA enables aspartic-type endopeptidase activity 10531052 Function
23621 GO:0005515 IPI enables protein binding 10677483,12901838,15286784,15466887,15886016,16407538,17573534..... Function
23621 GO:0008233 IDA enables peptidase activity 8562317 Function
23621 GO:0019899 IPI enables enzyme binding 12586838 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23621 GO:0005764 IDA located_in lysosome 16033761,23109336,27084579,27302062 Component
23621 GO:0005768 IDA located_in endosome 10531052 Component
23621 GO:0005769 IDA located_in early endosome 15886016,23109336,24305806,27084579,27302062 Component
23621 GO:0005770 IDA located_in late endosome 16033761,23109336,24612608,27084579,27302062 Component
23621 GO:0005771 IDA located_in multivesicular body 24612608 Component
23621 GO:0005794 IDA located_in Golgi apparatus 10531052,11466313,12586838 Component
23621 GO:0005802 IDA located_in trans-Golgi network 11466313,15886016,23109336 Component
23621 GO:0005886 IDA located_in plasma membrane 12586838,24612608 Component
23621 GO:0009986 IDA located_in cell surface 15886016,23109336 Component
23621 GO:0055037 IDA located_in recycling endosome 15886016,27084579,27302062 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23621 GO:0006508 IDA involved_in proteolysis 10531052,10677483 Process
23621 GO:0006509 IDA involved_in membrane protein ectodomain proteolysis 18353773 Process
23621 GO:0016485 IDA involved_in protein processing 10531052 Process
23621 GO:0034205 IDA involved_in amyloid-beta formation 24352696 Process
23621 GO:0043525 IGI involved_in positive regulation of neuron apoptotic process 29371969 Process
23621 GO:0050435 IDA involved_in amyloid-beta metabolic process 10677483,15080893 Process