Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 23821
  • Symbol: Bace1
  • Description: beta-site APP cleaving enzyme 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23821 GO:0004175 IDA enables endopeptidase activity 15123597 Function
23821 GO:0004175 IMP enables endopeptidase activity 17099708 Function
23821 GO:0004190 IDA enables aspartic-type endopeptidase activity 25592972 Function
23821 GO:0004190 IMP enables aspartic-type endopeptidase activity 29325091 Function
23821 GO:0005515 IPI enables protein binding 15606899,19935654,29325091 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23821 GO:0005768 IDA located_in endosome 19074428 Component
23821 GO:0005769 IDA located_in early endosome 25592972 Component
23821 GO:0005802 IDA located_in trans-Golgi network 19074428 Component
23821 GO:0005886 IDA located_in plasma membrane 29325091 Component
23821 GO:0005886 IMP is_active_in plasma membrane 17099708 Component
23821 GO:0009986 IDA located_in cell surface 26467158 Component
23821 GO:0016020 IDA located_in membrane 15886206 Component
23821 GO:0030424 IDA located_in axon 11740561 Component
23821 GO:0031410 IDA located_in cytoplasmic vesicle 11740561 Component
23821 GO:0055037 IDA located_in recycling endosome 23931995 Component
23821 GO:0098686 IDA is_active_in hippocampal mossy fiber to CA3 synapse 18753368,23820808 Component
23821 GO:0098686 IMP is_active_in hippocampal mossy fiber to CA3 synapse 18753368 Component
23821 GO:0098793 IDA is_active_in presynapse 23820808 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
23821 GO:0006508 IDA acts_upstream_of_or_within proteolysis 15123597 Process
23821 GO:0006509 IMP involved_in membrane protein ectodomain proteolysis 29325091 Process
23821 GO:0042987 IGI involved_in amyloid precursor protein catabolic process 20704561 Process
23821 GO:0050435 IDA acts_upstream_of_or_within amyloid-beta metabolic process 25592972 Process
23821 GO:0050804 IGI involved_in modulation of chemical synaptic transmission 20943921 Process
23821 GO:0099171 IDA involved_in presynaptic modulation of chemical synaptic transmission 18753368 Process
23821 GO:0099171 IMP involved_in presynaptic modulation of chemical synaptic transmission 18753368 Process
23821 GO:0140448 IMP involved_in signaling receptor ligand precursor processing 17099708 Process