Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 2395
  • Symbol: FXN
  • Description: frataxin

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2395 GO:0004322 IDA enables ferroxidase activity 15641778 Function
2395 GO:0005515 IPI enables protein binding 15123683,15961414,26702583,31101807,32296183,32814053..... Function
2395 GO:0008198 IDA enables ferrous iron binding 12785837,15123683,17285345,29576242 Function
2395 GO:0008199 IDA enables ferric iron binding 12785837,18537827 Function
2395 GO:0034986 IDA enables iron chaperone activity 15123683 Function
2395 GO:0051537 IDA enables 2 iron, 2 sulfur cluster binding 12785837 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2395 GO:0005739 IDA located_in mitochondrion 17468497,21298097 Component
2395 GO:0005829 IDA located_in cytosol 17468497 Component
2395 GO:0099128 IDA part_of mitochondrial iron-sulfur cluster assembly complex 21298097,31101807 Component
2395 GO:1990221 IDA part_of L-cysteine desulfurase complex 29491838 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2395 GO:0006879 IMP involved_in intracellular iron ion homeostasis 18160053 Process
2395 GO:0008284 IMP involved_in positive regulation of cell population proliferation 18160053 Process
2395 GO:0010039 IMP involved_in response to iron ion 18424449 Process
2395 GO:0010722 IDA involved_in regulation of ferrochelatase activity 15123683 Process
2395 GO:0016226 IDA involved_in iron-sulfur cluster assembly 29491838 Process
2395 GO:0016540 IDA involved_in protein autoprocessing 12785837 Process
2395 GO:0018283 IDA involved_in iron incorporation into metallo-sulfur cluster 12785837 Process
2395 GO:0030307 IMP involved_in positive regulation of cell growth 15509595 Process
2395 GO:0043066 IMP involved_in negative regulation of apoptotic process 16608849 Process
2395 GO:0043085 IMP involved_in positive regulation of catalytic activity 15509595 Process
2395 GO:0044571 IDA involved_in [2Fe-2S] cluster assembly 24971490,29576242 Process
2395 GO:0044572 IDA acts_upstream_of [4Fe-4S] cluster assembly 29576242 Process
2395 GO:0051349 IDA involved_in positive regulation of lyase activity 20053667 Process
2395 GO:0051349 IMP involved_in positive regulation of lyase activity 18160053 Process
2395 GO:0070301 IDA involved_in cellular response to hydrogen peroxide 15641778 Process
2395 GO:0090201 IMP involved_in negative regulation of release of cytochrome c from mitochondria 16608849 Process
2395 GO:1904231 IMP involved_in positive regulation of succinate dehydrogenase activity 18160053 Process
2395 GO:1904234 IMP involved_in positive regulation of aconitate hydratase activity 18160053 Process