Gene Ontology

Gene Info

  • Species: Rat (Rattus norvegicus)
  • GeneID: 25467
  • Symbol: Irs1
  • Description: insulin receptor substrate 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25467 GO:0005068 IMP enables transmembrane receptor protein tyrosine kinase adaptor activity 18285345 Function
25467 GO:0005080 IPI enables protein kinase C binding 18285345 Function
25467 GO:0005158 IMP enables insulin receptor binding 12850498 Function
25467 GO:0005159 IPI enables insulin-like growth factor receptor binding 15272025 Function
25467 GO:0005515 IPI enables protein binding 1380456,7504175,8491186,8631859,9295312,10660596,11018022,1113..... Function
25467 GO:0019901 IPI enables protein kinase binding 15701573 Function
25467 GO:0019904 IPI enables protein domain specific binding 12891559 Function
25467 GO:0042169 IPI enables SH2 domain binding 8491186 Function
25467 GO:0043548 IDA enables phosphatidylinositol 3-kinase binding 1380456 Function
25467 GO:0043548 IMP enables phosphatidylinositol 3-kinase binding 12850498 Function
25467 GO:0043548 IPI enables phosphatidylinositol 3-kinase binding 12891559 Function
25467 GO:0044877 IDA enables protein-containing complex binding 15272025 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25467 GO:0005899 IMP part_of insulin receptor complex 15069075 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25467 GO:0008286 IDA involved_in insulin receptor signaling pathway 17925406 Process
25467 GO:0014823 IEP involved_in response to activity 22015326 Process
25467 GO:0031000 IDA involved_in response to caffeine 21940847 Process
25467 GO:0031000 IEP involved_in response to caffeine 22995397 Process
25467 GO:0042327 IDA involved_in positive regulation of phosphorylation 12435589 Process
25467 GO:0043434 IDA involved_in response to peptide hormone 9295312 Process
25467 GO:0043552 IDA involved_in positive regulation of phosphatidylinositol 3-kinase activity 1380456 Process
25467 GO:0046627 IMP involved_in negative regulation of insulin receptor signaling pathway 15069075 Process
25467 GO:0046628 IMP involved_in positive regulation of insulin receptor signaling pathway 18285345 Process
25467 GO:0046676 IMP involved_in negative regulation of insulin secretion 12435589 Process
25467 GO:0070094 IMP involved_in positive regulation of glucagon secretion 12435589 Process
25467 GO:0071478 IEP involved_in cellular response to radiation 17427956 Process
25467 GO:0090275 IMP involved_in negative regulation of somatostatin secretion 12435589 Process
25467 GO:1904385 IEP involved_in cellular response to angiotensin 8579617 Process
25467 GO:1990416 IEP involved_in cellular response to brain-derived neurotrophic factor stimulus 17467122 Process