Gene Ontology

Gene Info

  • Species: Rat (Rattus norvegicus)
  • GeneID: 25608
  • Symbol: Lep
  • Description: leptin

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25608 GO:0001542 IDA involved_in ovulation from ovarian follicle 17071778 Process
25608 GO:0001666 IEP involved_in response to hypoxia 15284063 Process
25608 GO:0001819 IEP involved_in positive regulation of cytokine production 19922787 Process
25608 GO:0002021 IMP involved_in response to dietary excess 19726711 Process
25608 GO:0003300 IDA involved_in cardiac muscle hypertrophy 20738325 Process
25608 GO:0006112 IDA involved_in energy reserve metabolic process 12058043 Process
25608 GO:0006114 IDA involved_in glycerol biosynthetic process 21068181 Process
25608 GO:0006909 IDA involved_in phagocytosis 9438411 Process
25608 GO:0007565 IEP involved_in female pregnancy 21303957 Process
25608 GO:0007584 IEP involved_in response to nutrient 15616803,29089335 Process
25608 GO:0007623 IEP involved_in circadian rhythm 21164040 Process
25608 GO:0008217 IDA involved_in regulation of blood pressure 20059648 Process
25608 GO:0008284 IDA involved_in positive regulation of cell population proliferation 18978578 Process
25608 GO:0009062 IDA involved_in fatty acid catabolic process 12058043 Process
25608 GO:0009892 IDA involved_in negative regulation of metabolic process 12130569 Process
25608 GO:0010888 IDA involved_in negative regulation of lipid storage 17024416 Process
25608 GO:0014068 IDA involved_in positive regulation of phosphatidylinositol 3-kinase signaling 11677594 Process
25608 GO:0014823 IEP involved_in response to activity 23178146 Process
25608 GO:0031667 IEP involved_in response to nutrient levels 21060836,25943649 Process
25608 GO:0032355 IEP involved_in response to estradiol 12412816 Process
25608 GO:0033197 IEP involved_in response to vitamin E 20404018 Process
25608 GO:0033210 IDA involved_in leptin-mediated signaling pathway 9070213,9618284,11677594 Process
25608 GO:0033686 IEP involved_in positive regulation of luteinizing hormone secretion 19112389 Process
25608 GO:0035360 IDA involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway 20738325 Process
25608 GO:0035556 IDA involved_in intracellular signal transduction 12130569 Process
25608 GO:0035630 IDA involved_in bone mineralization involved in bone maturation 21353474 Process
25608 GO:0038108 IDA involved_in negative regulation of appetite by leptin-mediated signaling pathway 11677594 Process
25608 GO:0042531 IMP involved_in positive regulation of tyrosine phosphorylation of STAT protein 19726711 Process
25608 GO:0043066 IDA involved_in negative regulation of apoptotic process 19730157 Process
25608 GO:0043270 IDA involved_in positive regulation of monoatomic ion transport 20203064 Process
25608 GO:0043410 IDA involved_in positive regulation of MAPK cascade 9618284 Process
25608 GO:0045471 IEP involved_in response to ethanol 23380443,29089335 Process
25608 GO:0045906 IDA involved_in negative regulation of vasoconstriction 20978518 Process
25608 GO:0046427 IMP involved_in positive regulation of receptor signaling pathway via JAK-STAT 21250909 Process
25608 GO:0046628 IDA involved_in positive regulation of insulin receptor signaling pathway 20977462 Process
25608 GO:0046881 IEP involved_in positive regulation of follicle-stimulating hormone secretion 19112389 Process
25608 GO:0050901 IDA involved_in leukocyte tethering or rolling 20150963 Process
25608 GO:0060587 IDA involved_in regulation of lipoprotein lipid oxidation 21068181 Process
25608 GO:0061037 IDA involved_in negative regulation of cartilage development 19876764 Process
25608 GO:0071298 IEP involved_in cellular response to L-ascorbic acid 20400526 Process
25608 GO:0071300 IEP involved_in cellular response to retinoic acid 19212007 Process
25608 GO:1904651 IDA involved_in positive regulation of fat cell apoptotic process 17024416 Process
25608 GO:2000379 IDA involved_in positive regulation of reactive oxygen species metabolic process 20738325 Process
25608 GO:2000486 IMP involved_in negative regulation of glutamine transport 20448142 Process
25608 GO:2000491 IDA involved_in positive regulation of hepatic stellate cell activation 19299451 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25608 GO:0005102 IPI enables signaling receptor binding 15131016 Function
25608 GO:0005179 IDA enables hormone activity 9070213 Function
25608 GO:0005515 IPI enables protein binding 17324488 Function
25608 GO:0051428 IDA enables peptide hormone receptor binding 9070213 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25608 GO:0005615 IDA located_in extracellular space 9590691,21060836,25943649,29089335 Component
25608 GO:0005829 IDA located_in cytosol 17324488 Component