Gene Ontology

Gene Info

• Species: Rat (Rattus norvegicus)
• GeneID: 25700
• Symbol: Ide
• Description: insulin degrading enzyme

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
25700	GO:0001540	IPI	enables	amyloid-beta binding	18411275	Function
25700	GO:0004222	IDA	enables	metalloendopeptidase activity	15494400	Function
25700	GO:0004222	IMP	enables	metalloendopeptidase activity	15749695	Function
25700	GO:0005524	IMP	enables	ATP binding	15749695	Function
25700	GO:0005524	IPI	enables	ATP binding	17259336	Function
25700	GO:0008270	IMP	enables	zinc ion binding	15749695	Function
25700	GO:0016887	IDA	enables	ATP hydrolysis activity	17259336	Function
25700	GO:0017046	IPI	enables	peptide hormone binding	15494400	Function
25700	GO:0031626	IMP	enables	beta-endorphin binding	15749695	Function
25700	GO:0042802	IPI	enables	identical protein binding	15494400	Function
25700	GO:0043559	IMP	enables	insulin binding	15749695	Function
25700	GO:0044877	IDA	enables	protein-containing complex binding	9000694	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
25700	GO:0005615	IDA	located_in	extracellular space	10684867	Component
25700	GO:0005782	IDA	located_in	peroxisomal matrix	11235899	Component
25700	GO:0009986	IDA	located_in	cell surface	10684867	Component
25700	GO:0031597	IDA	part_of	cytosolic proteasome complex	9000694	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
25700	GO:0030163	IDA	involved_in	protein catabolic process	11235899	Process
25700	GO:0042447	IDA	involved_in	hormone catabolic process	15494400	Process
25700	GO:0045861	IDA	involved_in	negative regulation of proteolysis	9000694	Process
25700	GO:0050435	IMP	involved_in	amyloid-beta metabolic process	15749695,18411275	Process
25700	GO:0051603	IMP	involved_in	proteolysis involved in protein catabolic process	15749695	Process
25700	GO:0097242	IGI	involved_in	amyloid-beta clearance	19406747	Process
25700	GO:0097242	IMP	involved_in	amyloid-beta clearance	10684867	Process
25700	GO:0150094	IMP	involved_in	amyloid-beta clearance by cellular catabolic process	18941241	Process