Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 25836
• Symbol: NIPBL
• Description: NIPBL cohesin loading factor

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
25836	GO:0000122	IDA	involved_in	negative regulation of transcription by RNA polymerase II	18854353	Process
25836	GO:0003007	IMP	involved_in	heart morphogenesis	8291537	Process
25836	GO:0003151	IMP	involved_in	outflow tract morphogenesis	19242925	Process
25836	GO:0006974	IMP	involved_in	DNA damage response	17468178	Process
25836	GO:0007064	IDA	involved_in	mitotic sister chromatid cohesion	22628566	Process
25836	GO:0007064	IMP	involved_in	mitotic sister chromatid cohesion	16100726	Process
25836	GO:0007420	IMP	involved_in	brain development	8291537	Process
25836	GO:0007605	IMP	involved_in	sensory perception of sound	15146186	Process
25836	GO:0008104	IMP	involved_in	protein localization	17468178	Process
25836	GO:0031065	IDA	involved_in	positive regulation of histone deacetylation	18854353	Process
25836	GO:0034088	IMP	involved_in	maintenance of mitotic sister chromatid cohesion	16682347	Process
25836	GO:0035115	IMP	involved_in	embryonic forelimb morphogenesis	8291537,19242925	Process
25836	GO:0035136	IMP	involved_in	forelimb morphogenesis	15146186	Process
25836	GO:0035261	IMP	involved_in	external genitalia morphogenesis	15146186,19242925	Process
25836	GO:0042471	IMP	involved_in	ear morphogenesis	8291537	Process
25836	GO:0042634	IMP	involved_in	regulation of hair cycle	15146186	Process
25836	GO:0045892	IDA	involved_in	negative regulation of DNA-templated transcription	18854353	Process
25836	GO:0045995	IMP	involved_in	regulation of embryonic development	19242925	Process
25836	GO:0048557	IMP	involved_in	embryonic digestive tract morphogenesis	8291537,19242925	Process
25836	GO:0048589	IMP	involved_in	developmental growth	15146186	Process
25836	GO:0048592	IMP	involved_in	eye morphogenesis	8291537	Process
25836	GO:0048638	IMP	involved_in	regulation of developmental growth	19242925	Process
25836	GO:0050890	IMP	involved_in	cognition	15146186	Process
25836	GO:0060325	IMP	involved_in	face morphogenesis	15146186,19242925	Process
25836	GO:0061010	IMP	involved_in	gallbladder development	19242925	Process
25836	GO:0061038	IMP	involved_in	uterus morphogenesis	19242925	Process
25836	GO:0071481	IMP	involved_in	cellular response to X-ray	17468178	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
25836	GO:0005515	IPI	enables	protein binding	16682347,16802858,17577209,21934712,22628566,26496610.....	Function
25836	GO:0042826	IPI	enables	histone deacetylase binding	18854353	Function
25836	GO:0061775	IMP	enables	cohesin loader activity	22628566	Function
25836	GO:0070087	IPI	enables	chromo shadow domain binding	15882967	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
25836	GO:0005634	IDA	located_in	nucleus	16802858	Component
25836	GO:0005654	IDA	located_in	nucleoplasm		Component
25836	GO:0005829	IDA	located_in	cytosol		Component
25836	GO:0032116	IDA	part_of	SMC loading complex	16682347	Component
25836	GO:0043231	IDA	located_in	intracellular membrane-bounded organelle		Component
25836	GO:0070062	HDA	located_in	extracellular exosome	19056867	Component
25836	GO:0090694	IDA	part_of	Scc2-Scc4 cohesin loading complex	22628566	Component