Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 2629
• Symbol: GBA
• Description: glucosylceramidase beta

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
2629	GO:0004348	IDA	enables	glucosylceramidase activity	9201993,16293621,19279011,24211208	Function
2629	GO:0004348	IMP	enables	glucosylceramidase activity	15916907,21700325,23580063	Function
2629	GO:0005124	IPI	enables	scavenger receptor binding	25202012	Function
2629	GO:0005515	IPI	enables	protein binding	21098288,24162852,27789271	Function
2629	GO:0046527	IDA	enables	glucosyltransferase activity	24211208,26724485	Function
2629	GO:0050295	IDA	enables	steryl-beta-glucosidase activity	24211208,26724485	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
2629	GO:0005764	IMP	located_in	lysosome	25202012	Component
2629	GO:0005765	HDA	located_in	lysosomal membrane	17897319	Component
2629	GO:0005765	IDA	located_in	lysosomal membrane	17187079	Component
2629	GO:0070062	HDA	located_in	extracellular exosome	23533145	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
2629	GO:0006680	IDA	involved_in	glucosylceramide catabolic process	9201993,16293621,24211208	Process
2629	GO:0006680	IMP	involved_in	glucosylceramide catabolic process	19279011,21700325,24022302	Process
2629	GO:0006914	IMP	involved_in	autophagy	27378698	Process
2629	GO:0007005	IMP	NOT involved_in	mitochondrion organization	25456120	Process
2629	GO:0007040	IMP	involved_in	lysosome organization	27378698	Process
2629	GO:0008203	IDA	involved_in	cholesterol metabolic process	24211208,26724485	Process
2629	GO:0023021	IMP	involved_in	termination of signal transduction	19279008	Process
2629	GO:0030259	IDA	involved_in	lipid glycosylation	24211208,26724485	Process
2629	GO:0031175	IMP	NOT involved_in	neuron projection development	25456120	Process
2629	GO:0031333	IDA	involved_in	negative regulation of protein-containing complex assembly	26392287	Process
2629	GO:0032006	IMP	involved_in	regulation of TOR signaling	27378698	Process
2629	GO:0032715	IDA	involved_in	negative regulation of interleukin-6 production	19279008	Process
2629	GO:0035307	IMP	involved_in	positive regulation of protein dephosphorylation	19279008	Process
2629	GO:0043243	IDA	involved_in	positive regulation of protein-containing complex disassembly	26392287	Process
2629	GO:0043407	IMP	involved_in	negative regulation of MAP kinase activity	19279008	Process
2629	GO:0046512	IMP	involved_in	sphingosine biosynthetic process	19279011	Process
2629	GO:0046513	IMP	involved_in	ceramide biosynthetic process	19279011	Process
2629	GO:0051246	IMP	involved_in	regulation of protein metabolic process	25456120	Process
2629	GO:0051247	IGI	involved_in	positive regulation of protein metabolic process	26392287	Process
2629	GO:0071356	IMP	involved_in	cellular response to tumor necrosis factor	19279008	Process
2629	GO:1901215	IGI	involved_in	negative regulation of neuron death	26392287	Process
2629	GO:1903052	IMP	involved_in	positive regulation of proteolysis involved in protein catabolic process	21700325	Process
2629	GO:1903061	IGI	involved_in	positive regulation of protein lipidation	26392287	Process
2629	GO:1904457	IMP	involved_in	positive regulation of neuronal action potential	25456120	Process