Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 29110
  • Symbol: TBK1
  • Description: TANK binding kinase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
29110 GO:0002218 IDA involved_in activation of innate immune response 25636800 Process
29110 GO:0002753 IDA involved_in cytosolic pattern recognition receptor signaling pathway 29441066 Process
29110 GO:0006468 IDA involved_in protein phosphorylation 27103069 Process
29110 GO:0010508 IDA involved_in positive regulation of autophagy 28871090 Process
29110 GO:0016239 IDA involved_in positive regulation of macroautophagy 27103069 Process
29110 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 25636800,25803835,27103069 Process
29110 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 25636800,27103069 Process
29110 GO:0032479 IDA involved_in regulation of type I interferon production 25636800 Process
29110 GO:0032481 IDA involved_in positive regulation of type I interferon production 14703513,25636800,29441066 Process
29110 GO:0032727 IDA involved_in positive regulation of interferon-alpha production 16127453 Process
29110 GO:0032728 IDA involved_in positive regulation of interferon-beta production 16127453 Process
29110 GO:0043123 IEP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 12761501 Process
29110 GO:0045087 IDA involved_in innate immune response 25636800 Process
29110 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 16127453 Process
29110 GO:0140374 IDA involved_in antiviral innate immune response 14703513,22394562 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
29110 GO:0004674 EXP enables protein serine/threonine kinase activity 30420664 Function
29110 GO:0004674 IDA enables protein serine/threonine kinase activity 14703513,22394562,22921120,25636800,25803835,27103069,29441066..... Function
29110 GO:0005515 IPI enables protein binding 14743216,15841462,16281057,16306936,17568778,17599067,18307994..... Function
29110 GO:0051219 IPI enables phosphoprotein binding 14530355 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
29110 GO:0005654 IDA located_in nucleoplasm Component
29110 GO:0005737 IDA is_active_in cytoplasm 14703513 Component
29110 GO:0005737 IDA located_in cytoplasm 21813773,29251827 Component
29110 GO:0005829 IDA is_active_in cytosol 21813773 Component
29110 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component