Gene Ontology

Gene Info

  • Species: Rat (Rattus norvegicus)
  • GeneID: 309757
  • Symbol: Sirt1
  • Description: sirtuin 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
309757 GO:0006476 IDA involved_in protein deacetylation 19356683 Process
309757 GO:0010046 IEP involved_in response to mycotoxin 18538940 Process
309757 GO:0010460 IMP involved_in positive regulation of heart rate 22113495 Process
309757 GO:0010659 IMP involved_in cardiac muscle cell apoptotic process 16207712 Process
309757 GO:0010667 IMP involved_in negative regulation of cardiac muscle cell apoptotic process 20089851 Process
309757 GO:0010976 IMP involved_in positive regulation of neuron projection development 20434449 Process
309757 GO:0014858 IMP involved_in positive regulation of skeletal muscle cell proliferation 18922599 Process
309757 GO:0031667 IEP involved_in response to nutrient levels 15205477 Process
309757 GO:0032720 IMP involved_in negative regulation of tumor necrosis factor production 19299582 Process
309757 GO:0035774 IMP involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus 16366736 Process
309757 GO:0042311 IMP involved_in vasodilation 23826814 Process
309757 GO:0043392 IMP involved_in negative regulation of DNA binding 22044919 Process
309757 GO:0043524 IMP involved_in negative regulation of neuron apoptotic process 24755072,29358553 Process
309757 GO:0045471 IDA involved_in response to ethanol 24570955 Process
309757 GO:0045722 IMP involved_in positive regulation of gluconeogenesis 21212096 Process
309757 GO:0051402 IMP involved_in neuron apoptotic process 24183892 Process
309757 GO:0060125 IMP involved_in negative regulation of growth hormone secretion 23292070 Process
309757 GO:0061051 IMP involved_in positive regulation of cell growth involved in cardiac muscle cell development 25281201 Process
309757 GO:0070301 IEP involved_in cellular response to hydrogen peroxide 17581637 Process
309757 GO:0070932 IMP involved_in histone H3 deacetylation 20089851 Process
309757 GO:0071236 IEP involved_in cellular response to antibiotic 17581637 Process
309757 GO:0071303 IEP involved_in cellular response to vitamin B3 23555824 Process
309757 GO:0071407 IEP involved_in cellular response to organic cyclic compound 18538940 Process
309757 GO:0090312 IMP involved_in positive regulation of protein deacetylation 19470756 Process
309757 GO:0097009 IMP involved_in energy homeostasis Process
309757 GO:1900181 IMP involved_in negative regulation of protein localization to nucleus 22044919 Process
309757 GO:1901984 IMP involved_in negative regulation of protein acetylation 22044919 Process
309757 GO:1902617 IEP involved_in response to fluoride 24296261 Process
309757 GO:1903427 IMP involved_in negative regulation of reactive oxygen species biosynthetic process 23422569 Process
309757 GO:1904373 IEP involved_in response to kainic acid 18538940 Process
309757 GO:1904638 IEP involved_in response to resveratrol 23555824,23747682 Process
309757 GO:1904644 IEP involved_in cellular response to curcumin 24755072 Process
309757 GO:1904646 IEP involved_in cellular response to amyloid-beta 23555824 Process
309757 GO:1904646 IMP involved_in cellular response to amyloid-beta 29358553 Process
309757 GO:1904648 IEP involved_in cellular response to rotenone 18538940 Process
309757 GO:2000270 IMP involved_in negative regulation of fibroblast apoptotic process 23479127 Process
309757 GO:2000614 IMP involved_in positive regulation of thyroid-stimulating hormone secretion 20668706 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
309757 GO:0017136 IDA enables NAD-dependent histone deacetylase activity 19356683 Function
309757 GO:0019899 IPI enables enzyme binding 19470756 Function
309757 GO:0043422 IDA enables protein kinase B binding 23475611 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
309757 GO:0030424 IDA located_in axon 23475611 Component
309757 GO:0030426 IDA located_in growth cone 23475611 Component