Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 3416
  • Symbol: IDE
  • Description: insulin degrading enzyme

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3416 GO:0004175 IDA enables endopeptidase activity 20364150 Function
3416 GO:0004222 IDA enables metalloendopeptidase activity 17051221,17613531 Function
3416 GO:0005515 IPI enables protein binding 17055432,17715127,20959807,32814053 Function
3416 GO:0005524 IDA enables ATP binding 17613531 Function
3416 GO:0008270 IDA enables zinc ion binding 17613531,19321446 Function
3416 GO:0042277 IPI enables peptide binding 20082125 Function
3416 GO:0042803 IDA enables protein homodimerization activity 17613531,19321446 Function
3416 GO:0043559 IDA enables insulin binding 17051221 Function
3416 GO:0043559 IPI enables insulin binding 20082125 Function
3416 GO:0140036 IPI enables ubiquitin-dependent protein binding 21185309 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3416 GO:0005615 IDA located_in extracellular space 9830016 Component
3416 GO:0005634 IDA NOT located_in nucleus 18226493 Component
3416 GO:0005634 IDA located_in nucleus 9231799,15285718 Component
3416 GO:0005737 IDA located_in cytoplasm 9231799,18226493,23525105 Component
3416 GO:0005739 IDA located_in mitochondrion 15285718,23525105 Component
3416 GO:0005777 IDA located_in peroxisome 9231799 Component
3416 GO:0005829 IDA located_in cytosol 9830016,15285718,20364150 Component
3416 GO:0009897 IDA located_in external side of plasma membrane 16511862 Component
3416 GO:0009986 IDA located_in cell surface 16511862,17055432 Component
3416 GO:0016323 IMP located_in basolateral plasma membrane 16511862 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3416 GO:0006508 IDA involved_in proteolysis 18602473,20082125,21185309 Process
3416 GO:0010815 IDA involved_in bradykinin catabolic process 17613531,21185309 Process
3416 GO:0010992 IDA involved_in ubiquitin recycling 21185309 Process
3416 GO:0019885 IMP involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I 20364150 Process
3416 GO:0030163 IMP involved_in protein catabolic process 20364150 Process
3416 GO:0032092 IDA involved_in positive regulation of protein binding 9830016 Process
3416 GO:0042447 IDA involved_in hormone catabolic process 19321446 Process
3416 GO:0043171 IDA involved_in peptide catabolic process 20364150 Process
3416 GO:0050435 IDA involved_in amyloid-beta metabolic process 9830016,17613531,26968463 Process
3416 GO:0051603 IDA involved_in proteolysis involved in protein catabolic process 9830016 Process
3416 GO:0097242 IMP involved_in amyloid-beta clearance 10684867,16511862 Process
3416 GO:0150094 IMP involved_in amyloid-beta clearance by cellular catabolic process 23525105 Process
3416 GO:1901142 IDA involved_in insulin metabolic process 18448515 Process
3416 GO:1901143 IDA involved_in insulin catabolic process 9231799,9830016,19321446 Process
3416 GO:1903715 IGI involved_in regulation of aerobic respiration 23525105 Process