Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 348
  • Symbol: APOE
  • Description: apolipoprotein E

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
348 GO:0001540 IDA enables amyloid-beta binding 8089103,11305869,25207746 Function
348 GO:0001540 IPI enables amyloid-beta binding 9003062,9211985,22138302 Function
348 GO:0005102 IPI enables signaling receptor binding 27477018 Function
348 GO:0005319 IDA enables lipid transporter activity 17305370 Function
348 GO:0005515 IPI enables protein binding 7972031,8245722,12950167,14754908,15182176,15615705,17116874,1..... Function
348 GO:0005543 IDA enables phospholipid binding 4066713 Function
348 GO:0008201 IDA enables heparin binding 2745454,7635945 Function
348 GO:0008289 IDA enables lipid binding 4066713 Function
348 GO:0016209 IDA enables antioxidant activity 9685360 Function
348 GO:0019899 IPI enables enzyme binding 15654758 Function
348 GO:0042802 IDA enables identical protein binding 4066713,8340399 Function
348 GO:0042803 IPI enables protein homodimerization activity 8089103,8245722,9211985 Function
348 GO:0043395 IDA enables heparan sulfate proteoglycan binding 9488694,23676495 Function
348 GO:0044877 IDA enables protein-containing complex binding 25207746 Function
348 GO:0046911 IDA enables metal chelating activity 9685360 Function
348 GO:0046983 IPI enables protein dimerization activity 22138302 Function
348 GO:0048156 IPI enables tau protein binding 7566652 Function
348 GO:0050750 IDA enables low-density lipoprotein particle receptor binding 210175,1530612,7635945 Function
348 GO:0050750 IPI enables low-density lipoprotein particle receptor binding 17326667 Function
348 GO:0060228 IDA enables phosphatidylcholine-sterol O-acyltransferase activator activity 15654758 Function
348 GO:0070326 IDA enables very-low-density lipoprotein particle receptor binding 1384047 Function
348 GO:0070326 IPI enables very-low-density lipoprotein particle receptor binding 12950167 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
348 GO:0001937 IDA involved_in negative regulation of endothelial cell proliferation 9685360 Process
348 GO:0006641 IDA involved_in triglyceride metabolic process 9649566 Process
348 GO:0006641 IMP involved_in triglyceride metabolic process 3771793 Process
348 GO:0006898 IDA involved_in receptor-mediated endocytosis 1917954 Process
348 GO:0007186 IDA involved_in G protein-coupled receptor signaling pathway 16443932 Process
348 GO:0007263 IDA involved_in nitric oxide mediated signal transduction 8995232 Process
348 GO:0007616 IGI involved_in long-term memory 24412220 Process
348 GO:0008203 IDA involved_in cholesterol metabolic process 9649566 Process
348 GO:0008203 IMP involved_in cholesterol metabolic process 3771793 Process
348 GO:0010544 IDA involved_in negative regulation of platelet activation 8995232 Process
348 GO:0010596 IMP involved_in negative regulation of endothelial cell migration 23142051 Process
348 GO:0010875 IDA involved_in positive regulation of cholesterol efflux 12042316,14754908 Process
348 GO:0010875 IGI involved_in positive regulation of cholesterol efflux 12401887 Process
348 GO:0010976 IDA involved_in positive regulation of neuron projection development 7592957,23845000 Process
348 GO:0010977 IDA involved_in negative regulation of neuron projection development 7592957 Process
348 GO:0015909 IDA involved_in long-chain fatty acid transport 24345162 Process
348 GO:0017038 IDA involved_in protein import 24446231 Process
348 GO:0019068 IMP involved_in virion assembly 25122793 Process
348 GO:0019934 IDA involved_in cGMP-mediated signaling 8995232 Process
348 GO:0030195 IDA involved_in negative regulation of blood coagulation 8995232 Process
348 GO:0031175 IDA involved_in neuron projection development 8939961 Process
348 GO:0032438 IMP involved_in melanosome organization 26387950 Process
348 GO:0032489 IDA involved_in regulation of Cdc42 protein signal transduction 16443932 Process
348 GO:0032805 IDA involved_in positive regulation of low-density lipoprotein particle receptor catabolic process 15950758 Process
348 GO:0033344 IDA involved_in cholesterol efflux 11162594,16443932,23620513 Process
348 GO:0033700 IDA involved_in phospholipid efflux 11162594 Process
348 GO:0034372 IDA involved_in very-low-density lipoprotein particle remodeling 15654758 Process
348 GO:0034372 IGI involved_in very-low-density lipoprotein particle remodeling 12401887 Process
348 GO:0034375 IGI involved_in high-density lipoprotein particle remodeling 12401887 Process
348 GO:0034380 IDA involved_in high-density lipoprotein particle assembly 14754908,17305370 Process
348 GO:0034382 IDA involved_in chylomicron remnant clearance 1911868 Process
348 GO:0034382 IMP involved_in chylomicron remnant clearance 7175379 Process
348 GO:0034384 IDA involved_in high-density lipoprotein particle clearance 210175 Process
348 GO:0034447 IDA involved_in very-low-density lipoprotein particle clearance 1917954,2762297 Process
348 GO:0034447 IMP involved_in very-low-density lipoprotein particle clearance 9649566 Process
348 GO:0035641 IMP involved_in locomotory exploration behavior 24412220 Process
348 GO:0042158 IDA involved_in lipoprotein biosynthetic process 23620513 Process
348 GO:0042632 IDA involved_in cholesterol homeostasis 9649566 Process
348 GO:0042632 IGI involved_in cholesterol homeostasis 24412220 Process
348 GO:0042982 IDA involved_in amyloid precursor protein metabolic process 21593558 Process
348 GO:0043254 IDA involved_in regulation of protein-containing complex assembly 25207746 Process
348 GO:0043407 IDA involved_in negative regulation of MAP kinase activity 9685360 Process
348 GO:0043537 IDA involved_in negative regulation of blood vessel endothelial cell migration 9685360 Process
348 GO:0043691 IDA involved_in reverse cholesterol transport 8127890 Process
348 GO:0044794 IMP involved_in positive regulation by host of viral process 25122793 Process
348 GO:0045541 IDA involved_in negative regulation of cholesterol biosynthetic process 1917954 Process
348 GO:0045807 IDA involved_in positive regulation of endocytosis 7683668,8300609 Process
348 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 28111074 Process
348 GO:0046889 IDA involved_in positive regulation of lipid biosynthetic process 12042316 Process
348 GO:0050709 IMP involved_in negative regulation of protein secretion 27044754 Process
348 GO:0051000 IDA involved_in positive regulation of nitric-oxide synthase activity 8995232 Process
348 GO:0051044 IDA involved_in positive regulation of membrane protein ectodomain proteolysis 15950758 Process
348 GO:0051044 IGI involved_in positive regulation of membrane protein ectodomain proteolysis 25015123 Process
348 GO:0051246 IGI involved_in regulation of protein metabolic process 24412220 Process
348 GO:0051248 IGI involved_in negative regulation of protein metabolic process 16805831 Process
348 GO:0055089 IDA involved_in fatty acid homeostasis 24345162 Process
348 GO:0060999 IDA acts_upstream_of_or_within positive regulation of dendritic spine development 24328732 Process
348 GO:0061136 IMP involved_in regulation of proteasomal protein catabolic process 28111074 Process
348 GO:0061771 IGI involved_in response to caloric restriction 24412220 Process
348 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 28111074 Process
348 GO:0071830 IMP involved_in triglyceride-rich lipoprotein particle clearance 23676495 Process
348 GO:0071831 IDA involved_in intermediate-density lipoprotein particle clearance 1917954 Process
348 GO:0090090 IDA involved_in negative regulation of canonical Wnt signaling pathway 16805831 Process
348 GO:0090090 IGI involved_in negative regulation of canonical Wnt signaling pathway 16805831 Process
348 GO:0090181 IGI involved_in regulation of cholesterol metabolic process 24412220 Process
348 GO:0090205 IDA involved_in positive regulation of cholesterol metabolic process 15654758 Process
348 GO:0097113 IDA acts_upstream_of_or_within_positive_effect AMPA glutamate receptor clustering 24328732 Process
348 GO:0097114 IDA acts_upstream_of_or_within_positive_effect NMDA glutamate receptor clustering 24328732 Process
348 GO:1900221 IDA involved_in regulation of amyloid-beta clearance 24446231 Process
348 GO:1900272 IDA involved_in negative regulation of long-term synaptic potentiation 16273551 Process
348 GO:1902430 IDA involved_in negative regulation of amyloid-beta formation 24154541 Process
348 GO:1902952 IDA acts_upstream_of_or_within positive regulation of dendritic spine maintenance 24328732 Process
348 GO:1902991 IDA involved_in regulation of amyloid precursor protein catabolic process 28164773 Process
348 GO:1902995 IDA involved_in positive regulation of phospholipid efflux 12042316 Process
348 GO:1903002 IDA involved_in positive regulation of lipid transport across blood-brain barrier 24345162 Process
348 GO:1905855 IDA involved_in positive regulation of heparan sulfate binding 7683668 Process
348 GO:1905860 IDA involved_in positive regulation of heparan sulfate proteoglycan binding 8300609 Process
348 GO:1905890 IDA involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus 7592957 Process
348 GO:1905906 IDA involved_in regulation of amyloid fibril formation 25207746 Process
348 GO:1905920 IDA involved_in positive regulation of CoA-transferase activity 15654758 Process
348 GO:2000822 IMP involved_in regulation of behavioral fear response 24412220 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
348 GO:0005576 HDA located_in extracellular region 27068509 Component
348 GO:0005576 IDA located_in extracellular region 8089103,16805831 Component
348 GO:0005615 HDA located_in extracellular space 16502470,20551380 Component
348 GO:0005615 IDA located_in extracellular space 8340399 Component
348 GO:0005634 HDA located_in nucleus 21630459 Component
348 GO:0005783 IDA located_in endoplasmic reticulum 25122793 Component
348 GO:0005794 IDA located_in Golgi apparatus 25122793 Component
348 GO:0016020 HDA located_in membrane 19946888 Component
348 GO:0031012 IDA located_in extracellular matrix 9488694 Component
348 GO:0034361 IDA part_of very-low-density lipoprotein particle 2280190,8071364,8245722,9211985,17154273,22138302 Component
348 GO:0034362 IDA part_of low-density lipoprotein particle 2280190,8245722,9211985,22138302 Component
348 GO:0034363 IDA part_of intermediate-density lipoprotein particle 2280190,9211985,17336988,22138302 Component
348 GO:0034364 IDA part_of high-density lipoprotein particle 210174,2280190,8071364,9211985,14754908,22138302 Component
348 GO:0042470 IDA located_in melanosome 26387950 Component
348 GO:0042627 IDA part_of chylomicron 8245722,16935699 Component
348 GO:0043083 IDA is_active_in synaptic cleft 22637583 Component
348 GO:0062023 HDA located_in collagen-containing extracellular matrix 23658023,27559042 Component
348 GO:0070062 HDA located_in extracellular exosome 19056867,20458337,23533145 Component
348 GO:0070062 IDA located_in extracellular exosome 26387950 Component
348 GO:0072562 HDA located_in blood microparticle 22516433 Component
348 GO:0097487 IDA located_in multivesicular body, internal vesicle 26387950 Component
348 GO:0098978 IDA is_active_in glutamatergic synapse 22637583 Component
348 GO:1903561 HDA located_in extracellular vesicle 24769233 Component
348 GO:1990777 IDA part_of lipoprotein particle 22138302 Component