Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 351
  • Symbol: APP
  • Description: amyloid beta precursor protein

Process

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
351 GO:0001774 IGI involved_in microglial cell activation 15457210,22406537 Process
351 GO:0001934 IDA involved_in positive regulation of protein phosphorylation 11404397 Process
351 GO:0001934 IGI involved_in positive regulation of protein phosphorylation 15457210 Process
351 GO:0002265 IGI involved_in astrocyte activation involved in immune response 23152628 Process
351 GO:0007611 IGI involved_in learning or memory 15457210,19587288,20164328,20445063,21113149,24012003,24052308..... Process
351 GO:0007611 IMP involved_in learning or memory 11880515,15457210 Process
351 GO:0007612 IMP involved_in learning 11140684 Process
351 GO:0008285 IDA involved_in negative regulation of cell population proliferation 22944668 Process
351 GO:0010468 IGI involved_in regulation of gene expression 21857966,26200696 Process
351 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 29274751 Process
351 GO:0010628 IGI involved_in positive regulation of gene expression 22198949,27853422,28008308,29061364 Process
351 GO:0010628 IMP involved_in positive regulation of gene expression 15457210,23164821 Process
351 GO:0010629 IGI involved_in negative regulation of gene expression 22198949,27853422,28008308,29061364 Process
351 GO:0010800 IMP involved_in positive regulation of peptidyl-threonine phosphorylation 19660551 Process
351 GO:0014005 IGI involved_in microglia development 22198949 Process
351 GO:0032092 IGI involved_in positive regulation of protein binding 24052308 Process
351 GO:0032722 IGI involved_in positive regulation of chemokine production 22406537 Process
351 GO:0032731 IGI involved_in positive regulation of interleukin-1 beta production 22406537 Process
351 GO:0032755 IGI involved_in positive regulation of interleukin-6 production 22406537 Process
351 GO:0032760 IGI involved_in positive regulation of tumor necrosis factor production 22198949,22406537,29061364 Process
351 GO:0033138 IMP involved_in positive regulation of peptidyl-serine phosphorylation 19660551 Process
351 GO:0042327 IGI involved_in positive regulation of phosphorylation 25707991 Process
351 GO:0045821 IGI involved_in positive regulation of glycolytic process 29061364 Process
351 GO:0045944 IGI involved_in positive regulation of transcription by RNA polymerase II 23921129 Process
351 GO:0046330 IGI involved_in positive regulation of JNK cascade 23921129 Process
351 GO:0048143 IGI involved_in astrocyte activation 15457210,20445063 Process
351 GO:0048169 IGI involved_in regulation of long-term neuronal synaptic plasticity 23921129 Process
351 GO:0050729 IMP involved_in positive regulation of inflammatory response 29961672 Process
351 GO:0050730 IGI involved_in regulation of peptidyl-tyrosine phosphorylation 21857966 Process
351 GO:0050808 IGI involved_in synapse organization 19587288,24012003 Process
351 GO:0051091 IGI involved_in positive regulation of DNA-binding transcription factor activity 23921129 Process
351 GO:0051092 IGI involved_in positive regulation of NF-kappaB transcription factor activity 15457210 Process
351 GO:0051247 IMP involved_in positive regulation of protein metabolic process 11404397 Process
351 GO:0051402 IMP involved_in neuron apoptotic process 19225519 Process
351 GO:0070374 IGI involved_in positive regulation of ERK1 and ERK2 cascade 15457210 Process
351 GO:0098815 IGI involved_in modulation of excitatory postsynaptic potential 20974225 Process
351 GO:0150003 IGI involved_in regulation of spontaneous synaptic transmission 15457210 Process
351 GO:1900272 IGI involved_in negative regulation of long-term synaptic potentiation 15457210,16636059 Process
351 GO:1900273 IGI involved_in positive regulation of long-term synaptic potentiation 20974225 Process
351 GO:1901224 IGI involved_in positive regulation of NIK/NF-kappaB signaling 15457210 Process
351 GO:1901224 IMP involved_in positive regulation of NIK/NF-kappaB signaling 29961672 Process
351 GO:1904646 IGI involved_in cellular response to amyloid-beta 23152628 Process
351 GO:1905598 IGI NOT involved_in negative regulation of low-density lipoprotein receptor activity 20005821 Process
351 GO:1905606 IDA involved_in regulation of presynapse assembly 19726636 Process
351 GO:1905606 IMP involved_in regulation of presynapse assembly 19726636 Process
351 GO:1905908 IMP involved_in positive regulation of amyloid fibril formation 19660551 Process
351 GO:1990000 EXP involved_in amyloid fibril formation 9737846 Process
351 GO:1990000 IMP involved_in amyloid fibril formation 25620700 Process
351 GO:1990535 IGI involved_in neuron projection maintenance 20445063 Process
351 GO:2000406 IMP involved_in positive regulation of T cell migration 19660551 Process

Function

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
351 GO:0004867 IDA enables serine-type endopeptidase inhibitor activity 10652580 Function
351 GO:0005102 IPI enables signaling receptor binding 19849849 Function
351 GO:0005515 IPI enables protein binding 2119582,8626687,8855266,8887653,9223340,9338779,9461550,977438..... Function
351 GO:0019899 IPI enables enzyme binding 17112471,24499793 Function
351 GO:0042802 IPI enables identical protein binding 16286452,18805418,19549187,19754881,20573181,20818335,21113149..... Function
351 GO:0048018 IDA enables receptor ligand activity 29518356 Function
351 GO:0051425 IPI enables PTB domain binding 12805363 Function

Component

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
351 GO:0005615 HDA located_in extracellular space 16502470 Component
351 GO:0005615 IDA is_active_in extracellular space 29518356 Component
351 GO:0005615 IDA located_in extracellular space 23921129 Component
351 GO:0005641 IDA located_in nuclear envelope lumen 21989385 Component
351 GO:0005737 IDA located_in cytoplasm 18509662 Component
351 GO:0005768 IDA located_in endosome 18353773 Component
351 GO:0005769 IDA located_in early endosome 14527950 Component
351 GO:0005783 IDA located_in endoplasmic reticulum 14527950 Component
351 GO:0005794 IDA located_in Golgi apparatus 14527950,20427278 Component
351 GO:0005886 IDA located_in plasma membrane 12805363,20164328,20427278,28164773,28855300 Component
351 GO:0009986 IDA located_in cell surface 7593229,18353773 Component
351 GO:0043197 IDA located_in dendritic spine 11988176 Component
351 GO:0043198 IDA located_in dendritic shaft 11988176 Component
351 GO:0043235 IDA part_of receptor complex 23382219 Component
351 GO:0045121 IDA located_in membrane raft 24499793 Component
351 GO:0045202 IDA located_in synapse 11988176 Component
351 GO:0048471 IDA located_in perinuclear region of cytoplasm 20427278 Component
351 GO:0070062 HDA located_in extracellular exosome 19199708 Component