Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 3643
  • Symbol: INSR
  • Description: insulin receptor

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3643 GO:0001540 IPI enables amyloid-beta binding 19406747 Function
3643 GO:0004713 IDA enables protein tyrosine kinase activity 8496180 Function
3643 GO:0004713 IMP enables protein tyrosine kinase activity 7537849 Function
3643 GO:0005009 IDA enables insulin receptor activity 6849137,8440175 Function
3643 GO:0005159 IDA enables insulin-like growth factor receptor binding 8452530 Function
3643 GO:0005515 IPI enables protein binding 7493946,7537849,7935368,8452530,8702689,8999839,9506989,959372..... Function
3643 GO:0005524 IDA enables ATP binding 6849137 Function
3643 GO:0005525 IDA enables GTP binding 9092559 Function
3643 GO:0019904 IPI enables protein domain specific binding 16246733 Function
3643 GO:0031994 IPI enables insulin-like growth factor I binding 8452530 Function
3643 GO:0031995 IPI enables insulin-like growth factor II binding 12138094 Function
3643 GO:0043548 IPI enables phosphatidylinositol 3-kinase binding 7537849,8276809 Function
3643 GO:0043559 IDA enables insulin binding 8440175 Function
3643 GO:0043559 IPI enables insulin binding 8452530 Function
3643 GO:0043560 IPI enables insulin receptor substrate binding 7493946,7537849,7559478 Function
3643 GO:0044877 IPI enables protein-containing complex binding 19406747 Function
3643 GO:0051425 IPI enables PTB domain binding 7559478 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3643 GO:0001934 IDA involved_in positive regulation of protein phosphorylation 7556070 Process
3643 GO:0002092 IDA involved_in positive regulation of receptor internalization 25401701 Process
3643 GO:0003007 IMP involved_in heart morphogenesis 7693131 Process
3643 GO:0006355 IMP involved_in regulation of DNA-templated transcription 12881524 Process
3643 GO:0007186 IDA involved_in G protein-coupled receptor signaling pathway 9092559 Process
3643 GO:0008284 IDA involved_in positive regulation of cell population proliferation 17925406 Process
3643 GO:0008284 IMP involved_in positive regulation of cell population proliferation 12138094 Process
3643 GO:0008286 IDA involved_in insulin receptor signaling pathway 6849137,8440175,20455999 Process
3643 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 8496180 Process
3643 GO:0030335 IMP involved_in positive regulation of cell migration 12138094 Process
3643 GO:0032147 IMP involved_in activation of protein kinase activity 9819385 Process
3643 GO:0032148 IDA involved_in activation of protein kinase B activity 7556070 Process
3643 GO:0032869 IDA involved_in cellular response to insulin stimulus 8440175 Process
3643 GO:0042593 IMP involved_in glucose homeostasis 7693131 Process
3643 GO:0043406 IMP acts_upstream_of positive regulation of MAP kinase activity 17001305 Process
3643 GO:0043410 IDA involved_in positive regulation of MAPK cascade 20455999 Process
3643 GO:0043410 IMP involved_in positive regulation of MAPK cascade 11500939 Process
3643 GO:0045429 IMP involved_in positive regulation of nitric oxide biosynthetic process 10747347 Process
3643 GO:0045725 IDA involved_in positive regulation of glycogen biosynthetic process 17925406 Process
3643 GO:0045821 IMP involved_in positive regulation of glycolytic process 7693131 Process
3643 GO:0045840 IMP involved_in positive regulation of mitotic nuclear division 11500939 Process
3643 GO:0045995 IMP involved_in regulation of embryonic development 7693131 Process
3643 GO:0046326 IDA involved_in positive regulation of glucose import 3518947 Process
3643 GO:0046718 IMP involved_in viral entry into host cell 17001305 Process
3643 GO:0046777 IDA involved_in protein autophosphorylation 6849137,8496180 Process
3643 GO:0046777 IMP involved_in protein autophosphorylation 7537849 Process
3643 GO:0048639 IMP involved_in positive regulation of developmental growth 7693131 Process
3643 GO:0051897 IMP involved_in positive regulation of protein kinase B signaling 11500939 Process
3643 GO:0060267 IDA involved_in positive regulation of respiratory burst 9092559 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3643 GO:0005635 IDA colocalizes_with nuclear envelope 19406747 Component
3643 GO:0005886 IDA located_in plasma membrane 9092559,23137377 Component
3643 GO:0005899 IDA part_of insulin receptor complex 1898103,19406747 Component
3643 GO:0005899 IMP part_of insulin receptor complex 15069075 Component
3643 GO:0005901 IDA located_in caveola 15182363 Component
3643 GO:0016020 IDA located_in membrane 8452530 Component
3643 GO:0031981 IDA colocalizes_with nuclear lumen 19406747 Component
3643 GO:0043235 IDA part_of receptor complex 23382219 Component
3643 GO:0070062 HDA located_in extracellular exosome 20458337 Component