Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 3667
  • Symbol: IRS1
  • Description: insulin receptor substrate 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3667 GO:0001784 IPI enables phosphotyrosine residue binding 20624904 Function
3667 GO:0005158 IPI enables insulin receptor binding 7493946,7537849 Function
3667 GO:0005159 IPI enables insulin-like growth factor receptor binding 7541045 Function
3667 GO:0005515 IPI enables protein binding 7513703,7542742,7559478,7680095,7680644,7935368,8382612,838838..... Function
3667 GO:0030159 IDA enables signaling receptor complex adaptor activity 7493946 Function
3667 GO:0043548 IPI enables phosphatidylinositol 3-kinase binding 7782332,16043515 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3667 GO:0005654 IDA located_in nucleoplasm Component
3667 GO:0005829 IDA located_in cytosol Component
3667 GO:0005886 IDA located_in plasma membrane Component
3667 GO:0005901 IDA located_in caveola 15182363 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3667 GO:0008286 IDA involved_in insulin receptor signaling pathway 16516141,23401856 Process
3667 GO:0008286 IMP involved_in insulin receptor signaling pathway 16814735 Process
3667 GO:0008286 IPI involved_in insulin receptor signaling pathway 7537849,7559478 Process
3667 GO:0010907 IMP involved_in positive regulation of glucose metabolic process 16814735 Process
3667 GO:0014065 IDA involved_in phosphatidylinositol 3-kinase signaling 7782332 Process
3667 GO:0032000 IMP involved_in positive regulation of fatty acid beta-oxidation 16814735 Process
3667 GO:0032868 IDA involved_in response to insulin 16516141 Process
3667 GO:0032869 IMP involved_in cellular response to insulin stimulus 16814735 Process
3667 GO:0045725 IMP involved_in positive regulation of glycogen biosynthetic process 16814735 Process
3667 GO:0046326 IDA involved_in positive regulation of glucose import 7493946 Process
3667 GO:0046326 IMP involved_in positive regulation of glucose import 16814735 Process
3667 GO:0046628 IDA involved_in positive regulation of insulin receptor signaling pathway 7493946 Process
3667 GO:0046676 IDA involved_in negative regulation of insulin secretion 15572028 Process
3667 GO:0048009 IPI involved_in insulin-like growth factor receptor signaling pathway 7541045 Process