Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 3717
• Symbol: JAK2
• Description: Janus kinase 2

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
3717	GO:0004713	EXP	enables	protein tyrosine kinase activity	9111318,15143187,19665053,20304997	Function
3717	GO:0004713	IDA	enables	protein tyrosine kinase activity	8007942,23061660	Function
3717	GO:0005102	IPI	enables	signaling receptor binding	11201744	Function
3717	GO:0005515	IPI	enables	protein binding	9516124,11679576,11694501,11970898,15821101,16437163,17474147,.....	Function
3717	GO:0019901	IDA	enables	protein kinase binding	10925297	Function
3717	GO:0020037	IDA	enables	heme binding	21036157	Function
3717	GO:0035401	IDA	enables	histone H3Y41 kinase activity	19783980	Function
3717	GO:0042169	IPI	enables	SH2 domain binding	9727029	Function
3717	GO:0042393	IDA	enables	histone binding	19783980	Function
3717	GO:0042802	IPI	enables	identical protein binding	21841788,22820988	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
3717	GO:0005634	IDA	located_in	nucleus	10502458,19783980	Component
3717	GO:0005654	IDA	located_in	nucleoplasm		Component
3717	GO:0005737	IDA	located_in	cytoplasm	10502458	Component
3717	GO:0005886	IDA	located_in	plasma membrane		Component
3717	GO:0005925	IDA	located_in	focal adhesion		Component
3717	GO:0019897	IDA	is_active_in	extrinsic component of plasma membrane	8007942	Component
3717	GO:0030526	IDA	part_of	granulocyte macrophage colony-stimulating factor receptor complex	27396825	Component
3717	GO:0031234	IDA	is_active_in	extrinsic component of cytoplasmic side of plasma membrane	8007942	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
3717	GO:0006468	IDA	involved_in	protein phosphorylation	18692472	Process
3717	GO:0007259	IDA	involved_in	receptor signaling pathway via JAK-STAT	18692472,31145836	Process
3717	GO:0010572	IDA	acts_upstream_of_or_within	positive regulation of platelet activation	31145836	Process
3717	GO:0010811	IDA	involved_in	positive regulation of cell-substrate adhesion	10925297	Process
3717	GO:0019221	IDA	involved_in	cytokine-mediated signaling pathway	8609418	Process
3717	GO:0032729	IDA	involved_in	positive regulation of type II interferon production	12023369,19088061	Process
3717	GO:0032819	IDA	involved_in	positive regulation of natural killer cell proliferation	19088061	Process
3717	GO:0033209	IDA	involved_in	tumor necrosis factor-mediated signaling pathway	8609418	Process
3717	GO:0034612	IDA	involved_in	response to tumor necrosis factor	8609418	Process
3717	GO:0035722	IDA	involved_in	interleukin-12-mediated signaling pathway	7528775	Process
3717	GO:0038043	IDA	involved_in	interleukin-5-mediated signaling pathway	7613138	Process
3717	GO:0038065	IMP	involved_in	collagen-activated signaling pathway	31145836	Process
3717	GO:0038156	IDA	involved_in	interleukin-3-mediated signaling pathway	8007942	Process
3717	GO:0038157	IDA	involved_in	granulocyte-macrophage colony-stimulating factor signaling pathway	18692472	Process
3717	GO:0042102	IDA	involved_in	positive regulation of T cell proliferation	11114383	Process
3717	GO:0043687	IDA	involved_in	post-translational protein modification	19783980	Process
3717	GO:0046427	IDA	involved_in	positive regulation of receptor signaling pathway via JAK-STAT	7638186,12023369	Process
3717	GO:0046677	IDA	acts_upstream_of_or_within	response to antibiotic	16280321	Process
3717	GO:0050727	IDA	involved_in	regulation of inflammatory response	10925297	Process
3717	GO:0051142	IDA	involved_in	positive regulation of NK T cell proliferation	19088061	Process
3717	GO:0060391	IGI	acts_upstream_of_or_within	positive regulation of SMAD protein signal transduction	28334068	Process
3717	GO:0060396	IDA	involved_in	growth hormone receptor signaling pathway	10925297	Process
3717	GO:0070665	IDA	involved_in	positive regulation of leukocyte proliferation	18692472	Process
3717	GO:0070671	IDA	involved_in	response to interleukin-12	7528775	Process
3717	GO:1901731	IDA	acts_upstream_of	positive regulation of platelet aggregation	31145836	Process