Gene Ontology

Gene Info

• Species: Mouse (Mus musculus)
• GeneID: 384783
• Symbol: Irs2
• Description: insulin receptor substrate 2

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
384783	GO:0002053	IGI	acts_upstream_of_or_within	positive regulation of mesenchymal cell proliferation	17662267	Process
384783	GO:0002903	IMP	involved_in	negative regulation of B cell apoptotic process	15572028	Process
384783	GO:0007420	IMP	acts_upstream_of_or_within	brain development	12904469	Process
384783	GO:0008283	IGI	acts_upstream_of	cell population proliferation	17636024	Process
384783	GO:0008283	IMP	acts_upstream_of	cell population proliferation	12904469	Process
384783	GO:0008284	IMP	acts_upstream_of_or_within	positive regulation of cell population proliferation	12904469	Process
384783	GO:0008286	IDA	acts_upstream_of_or_within	insulin receptor signaling pathway	9813005	Process
384783	GO:0008286	IDA	involved_in	insulin receptor signaling pathway	7534300,8649419	Process
384783	GO:0008286	IMP	acts_upstream_of_or_within	insulin receptor signaling pathway	12488434	Process
384783	GO:0009749	IDA	involved_in	response to glucose	15572028	Process
384783	GO:0010631	IGI	acts_upstream_of	epithelial cell migration	17662267	Process
384783	GO:0010634	IGI	acts_upstream_of_or_within	positive regulation of epithelial cell migration	17662267	Process
384783	GO:0016477	IGI	acts_upstream_of	cell migration	17662267	Process
384783	GO:0030879	IGI	acts_upstream_of_or_within	mammary gland development	17662267	Process
384783	GO:0030890	IDA	involved_in	positive regulation of B cell proliferation	15572028	Process
384783	GO:0032024	IMP	involved_in	positive regulation of insulin secretion	15572028	Process
384783	GO:0032869	IDA	acts_upstream_of_or_within	cellular response to insulin stimulus	11375348	Process
384783	GO:0033673	IMP	involved_in	negative regulation of kinase activity	19523444	Process
384783	GO:0044342	IGI	acts_upstream_of	type B pancreatic cell proliferation	17636024	Process
384783	GO:1904692	IGI	acts_upstream_of_or_within	positive regulation of type B pancreatic cell proliferation	17636024	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
384783	GO:0005068	IDA	enables	transmembrane receptor protein tyrosine kinase adaptor activity	7534300	Function
384783	GO:0005515	IPI	enables	protein binding	9813005,17901049,18278056	Function
384783	GO:0019901	IDA	enables	protein kinase binding	14733908	Function
384783	GO:0030674	IDA	enables	protein-macromolecule adaptor activity	8649419	Function
384783	GO:0043548	IDA	enables	phosphatidylinositol 3-kinase binding	11375348	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
384783	GO:0005829	IDA	located_in	cytosol	17636024	Component
384783	GO:0005886	IDA	located_in	plasma membrane	11375348	Component