Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 4137
  • Symbol: MAPT
  • Description: microtubule associated protein tau

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4137 GO:0000226 IDA involved_in microtubule cytoskeleton organization 1057175 Process
4137 GO:0006974 IMP involved_in DNA damage response 21131359 Process
4137 GO:0007613 IMP involved_in memory 20655099 Process
4137 GO:0010506 IGI acts_upstream_of_or_within regulation of autophagy 19074461 Process
4137 GO:0010629 IMP involved_in negative regulation of gene expression 23164821 Process
4137 GO:0010917 IMP involved_in negative regulation of mitochondrial membrane potential 22920254 Process
4137 GO:0031110 IMP involved_in regulation of microtubule polymerization or depolymerization 27356871 Process
4137 GO:0031116 IDA involved_in positive regulation of microtubule polymerization 1421571,7706316 Process
4137 GO:0032930 IMP involved_in positive regulation of superoxide anion generation 22920254 Process
4137 GO:0033673 IMP involved_in negative regulation of kinase activity 20655099 Process
4137 GO:0045773 IDA involved_in positive regulation of axon extension 1389180 Process
4137 GO:0048312 IMP involved_in intracellular distribution of mitochondria 21854751 Process
4137 GO:0050808 IMP involved_in synapse organization 17270732 Process
4137 GO:0050848 IDA involved_in regulation of calcium-mediated signaling 18272392 Process
4137 GO:0051258 IMP involved_in protein polymerization 27044754 Process
4137 GO:0070507 IMP involved_in regulation of microtubule cytoskeleton organization 15147841 Process
4137 GO:0090258 IMP involved_in negative regulation of mitochondrial fission 22920254 Process
4137 GO:0097435 IDA involved_in supramolecular fiber organization 15654759 Process
4137 GO:0097435 IMP involved_in supramolecular fiber organization 14769047 Process
4137 GO:1900034 IMP involved_in regulation of cellular response to heat 21131359 Process
4137 GO:1901216 IMP involved_in positive regulation of neuron death 22920254 Process
4137 GO:1902474 IMP involved_in positive regulation of protein localization to synapse 20655099 Process
4137 GO:1903748 IMP involved_in negative regulation of establishment of protein localization to mitochondrion 22920254 Process
4137 GO:1903829 IMP involved_in positive regulation of protein localization 27356871 Process
4137 GO:1904428 IGI involved_in negative regulation of tubulin deacetylation 19457097 Process
4137 GO:1990000 IMP involved_in amyloid fibril formation 7929085 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4137 GO:0005515 IPI enables protein binding 3111527,7566652,9689133,10987820,15953362,16275660,16446437,17..... Function
4137 GO:0008017 IDA enables microtubule binding 1918161,28377597 Function
4137 GO:0008017 IMP enables microtubule binding 10747907 Function
4137 GO:0017124 IPI enables SH3 domain binding 9763511 Function
4137 GO:0019899 IPI enables enzyme binding 9736630,12888622,20133804 Function
4137 GO:0019901 IPI enables protein kinase binding 16923168,24251416 Function
4137 GO:0034185 IPI enables apolipoprotein binding 7566652 Function
4137 GO:0042802 IDA enables identical protein binding 15654759 Function
4137 GO:0042802 IMP enables identical protein binding 7929085,14769047,26014385 Function
4137 GO:0042802 IPI enables identical protein binding 16446437,27044754,30158706,30894745 Function
4137 GO:0051087 IPI enables protein-folding chaperone binding 25051234 Function
4137 GO:0051879 IPI enables Hsp90 protein binding 17517623 Function
4137 GO:0071813 IPI enables lipoprotein particle binding 7972031 Function
4137 GO:0099609 IMP enables microtubule lateral binding 15147841 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4137 GO:0005737 IDA located_in cytoplasm 23666762,27356871 Component
4137 GO:0005737 IMP located_in cytoplasm 26014385,27044754 Component
4137 GO:0005829 IDA located_in cytosol 10747907 Component
4137 GO:0005886 IDA located_in plasma membrane 8522593,10747907 Component
4137 GO:0015630 IDA located_in microtubule cytoskeleton 15147841,27356871,28377597 Component
4137 GO:0016020 IMP colocalizes_with membrane 20655099 Component
4137 GO:0016607 IDA located_in nuclear speck Component
4137 GO:0030424 IDA located_in axon 8642405 Component
4137 GO:0030425 IDA located_in dendrite 23666762,25620700 Component
4137 GO:0030426 IDA located_in growth cone 8642405 Component
4137 GO:0030673 IDA located_in axolemma 10747907 Component
4137 GO:0034399 IDA located_in nuclear periphery 19157893 Component
4137 GO:0036464 IDA located_in cytoplasmic ribonucleoprotein granule 15121898 Component
4137 GO:0036477 IMP located_in somatodendritic compartment 20655099 Component
4137 GO:0043025 IMP located_in neuronal cell body 20655099 Component
4137 GO:0044297 IDA located_in cell body 25620700 Component
4137 GO:0045298 IDA part_of tubulin complex 8642405 Component
4137 GO:0097418 IDA located_in neurofibrillary tangle 2484340 Component