Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 4221
  • Symbol: MEN1
  • Description: menin 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4221 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 9989505,12837246,22327296,23784080 Process
4221 GO:0000165 IDA involved_in MAPK cascade 12226747 Process
4221 GO:0001933 IDA involved_in negative regulation of protein phosphorylation 12226747 Process
4221 GO:0002076 IGI acts_upstream_of_or_within osteoblast development 15563473 Process
4221 GO:0006974 IDA involved_in DNA damage response 16690369 Process
4221 GO:0008285 IDA involved_in negative regulation of cell population proliferation 15331604 Process
4221 GO:0009411 IDA involved_in response to UV 16690369 Process
4221 GO:0010332 IDA involved_in response to gamma radiation 12874027 Process
4221 GO:0030511 IMP involved_in positive regulation of transforming growth factor beta receptor signaling pathway 11274402 Process
4221 GO:0043433 IDA involved_in negative regulation of DNA-binding transcription factor activity 11526476,12226747 Process
4221 GO:0045064 IDA involved_in T-helper 2 cell differentiation 20484083 Process
4221 GO:0045668 IGI acts_upstream_of_or_within negative regulation of osteoblast differentiation 15563473 Process
4221 GO:0045736 IMP involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity 15640349 Process
4221 GO:0045786 IDA involved_in negative regulation of cell cycle 15331604 Process
4221 GO:0045815 IMP involved_in transcription initiation-coupled chromatin remodeling 14992727 Process
4221 GO:0045892 IDA involved_in negative regulation of DNA-templated transcription 12226747 Process
4221 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 15199122 Process
4221 GO:0046329 IDA involved_in negative regulation of JNK cascade 12226747 Process
4221 GO:0051974 IMP involved_in negative regulation of telomerase activity 12837246 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4221 GO:0000400 IDA enables four-way junction DNA binding 15331604 Function
4221 GO:0000403 IDA enables Y-form DNA binding 15331604 Function
4221 GO:0000976 IDA enables transcription cis-regulatory region binding 20484083 Function
4221 GO:0003690 IDA enables double-stranded DNA binding 15331604 Function
4221 GO:0005515 IPI enables protein binding 9989505,11500056,11526476,12509449,12874027,14508515,14992727,..... Function
4221 GO:0030674 IDA enables protein-macromolecule adaptor activity 20484083 Function
4221 GO:0051219 IPI enables phosphoprotein binding 14992727 Function
4221 GO:0070412 IPI enables R-SMAD binding 11274402 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4221 GO:0000785 IDA part_of chromatin 12837246,12874027 Component
4221 GO:0005634 IDA located_in nucleus 9465067,14508515,15199122,15640349,17500065 Component
4221 GO:0005654 IDA located_in nucleoplasm Component
4221 GO:0005737 IDA located_in cytoplasm 11500056 Component
4221 GO:0005829 IDA located_in cytosol 14508515 Component
4221 GO:0016363 IDA located_in nuclear matrix 12874027 Component
4221 GO:0017053 IPI part_of transcription repressor complex 22327296 Component
4221 GO:0032154 IDA located_in cleavage furrow 14508515 Component
4221 GO:0032991 IDA part_of protein-containing complex 15199122 Component
4221 GO:0035097 IDA part_of histone methyltransferase complex 17500065 Component
4221 GO:0044665 IPI part_of MLL1/2 complex 23508102 Component
4221 GO:0071339 IPI part_of MLL1 complex 23508102 Component