Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 4311
  • Symbol: MME
  • Description: membrane metalloendopeptidase

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4311 GO:0001786 IDA enables phosphatidylserine binding 22183801 Function
4311 GO:0004175 IDA enables endopeptidase activity 8168535,15100223,15283675,18539150,20876573 Function
4311 GO:0004175 IGI enables endopeptidase activity 14749444 Function
4311 GO:0004175 IMP enables endopeptidase activity 2531377,19057576,24825898 Function
4311 GO:0004222 IDA enables metalloendopeptidase activity 6208535,6349683,15283675,27588448 Function
4311 GO:0004222 IMP enables metalloendopeptidase activity 2521388 Function
4311 GO:0005515 IPI enables protein binding 17342744,23289620,32814053 Function
4311 GO:0008238 IDA enables exopeptidase activity 6208535 Function
4311 GO:0008270 IDA enables zinc ion binding 8168535 Function
4311 GO:0042803 IPI enables protein homodimerization activity 22183801 Function
4311 GO:1901612 IDA enables cardiolipin binding 22183801 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4311 GO:0001822 IEP involved_in kidney development 22272689 Process
4311 GO:0006508 IDA involved_in proteolysis 8168535,15100223,18539150,18602473,20876573,27588448..... Process
4311 GO:0006508 IGI involved_in proteolysis 14749444 Process
4311 GO:0006508 IMP involved_in proteolysis 19057576,24825898 Process
4311 GO:0007611 IGI involved_in learning or memory 24825898 Process
4311 GO:0010814 IDA involved_in substance P catabolic process 6208535 Process
4311 GO:0010815 IDA involved_in bradykinin catabolic process 6349683 Process
4311 GO:0042447 IDA involved_in hormone catabolic process 6349683 Process
4311 GO:0046449 IMP involved_in creatinine metabolic process 22024547 Process
4311 GO:0050769 IGI involved_in positive regulation of neurogenesis 24825898 Process
4311 GO:0061837 IGI involved_in neuropeptide processing 24825898 Process
4311 GO:0071345 IDA involved_in cellular response to cytokine stimulus 20876573 Process
4311 GO:0071492 IDA involved_in cellular response to UV-A 20876573 Process
4311 GO:0071493 IDA involved_in cellular response to UV-B 20876573 Process
4311 GO:0090399 IEP involved_in replicative senescence 20876573 Process
4311 GO:0097242 IDA involved_in amyloid-beta clearance 12657655,15100223 Process
4311 GO:0097242 IGI involved_in amyloid-beta clearance 14749444 Process
4311 GO:0150094 IDA involved_in amyloid-beta clearance by cellular catabolic process 15100223 Process
4311 GO:0150094 IGI involved_in amyloid-beta clearance by cellular catabolic process 24825898 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4311 GO:0005737 IDA located_in cytoplasm 20876573,22272689 Component
4311 GO:0005769 IDA located_in early endosome 15100223 Component
4311 GO:0005802 IDA located_in trans-Golgi network 15100223 Component
4311 GO:0005886 IDA located_in plasma membrane 20876573,22272689 Component
4311 GO:0005903 IDA located_in brush border 22272689 Component
4311 GO:0005925 HDA located_in focal adhesion 21423176 Component
4311 GO:0030424 IGI located_in axon 14749444 Component
4311 GO:0031410 IDA located_in cytoplasmic vesicle 15100223 Component
4311 GO:0043025 IDA located_in neuronal cell body 15100223 Component
4311 GO:0043025 IGI located_in neuronal cell body 24825898 Component
4311 GO:0045121 IDA located_in membrane raft 15100223,22183801 Component
4311 GO:0070062 HDA located_in extracellular exosome 19056867,23533145 Component
4311 GO:0098793 IGI located_in presynapse 14749444 Component