Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 4361
  • Symbol: MRE11
  • Description: MRE11 homolog, double strand break repair nuclease

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4361 GO:0000014 IDA enables single-stranded DNA endodeoxyribonuclease activity 9705271 Function
4361 GO:0003677 IDA contributes_to DNA binding 15790808 Function
4361 GO:0003678 IMP contributes_to DNA helicase activity 15790808 Function
4361 GO:0004520 IDA enables DNA endonuclease activity 9705271 Function
4361 GO:0005515 IPI enables protein binding 9590181,12419185,15916964,16377563,17428914,17500065,17500595,..... Function
4361 GO:0008408 IDA enables 3'-5' exonuclease activity 9651580,9705271 Function
4361 GO:0008409 IDA enables 5'-3' exonuclease activity 29670289 Function
4361 GO:0042802 IPI enables identical protein binding 22078559 Function
4361 GO:0045296 HDA enables cadherin binding 25468996 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4361 GO:0000724 IDA involved_in double-strand break repair via homologous recombination 29670289,30612738 Process
4361 GO:0006303 IDA involved_in double-strand break repair via nonhomologous end joining 9651580 Process
4361 GO:0006974 IDA acts_upstream_of_or_within DNA damage response 17500065 Process
4361 GO:0006974 IDA involved_in DNA damage response 29670289 Process
4361 GO:0007062 IMP involved_in sister chromatid cohesion 15917200 Process
4361 GO:0031860 IMP involved_in telomeric 3' overhang formation 16374507 Process
4361 GO:0031954 IDA involved_in positive regulation of protein autophosphorylation 15790808 Process
4361 GO:0032206 IMP involved_in positive regulation of telomere maintenance 16374507 Process
4361 GO:0032508 IMP involved_in DNA duplex unwinding 15790808 Process
4361 GO:0033674 IDA involved_in positive regulation of kinase activity 15790808 Process
4361 GO:0043066 IMP involved_in negative regulation of apoptotic process 16374507 Process
4361 GO:0110025 IDA involved_in DNA strand resection involved in replication fork processing 29670289 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4361 GO:0000781 HDA located_in chromosome, telomeric region 19135898 Component
4361 GO:0000781 IDA colocalizes_with chromosome, telomeric region 15149599,24270157 Component
4361 GO:0000781 IDA located_in chromosome, telomeric region 10811102 Component
4361 GO:0005654 IDA located_in nucleoplasm Component
4361 GO:0005657 IDA located_in replication fork 29290612 Component
4361 GO:0005737 IDA located_in cytoplasm 25468996 Component
4361 GO:0016605 IDA located_in PML body 10811102 Component
4361 GO:0030870 IDA part_of Mre11 complex 10888888,19151086 Component
4361 GO:0030870 IPI part_of Mre11 complex 31147924 Component
4361 GO:0035861 IDA located_in site of double-strand break 15916964,30612738 Component
4361 GO:0070533 IPI part_of BRCA1-C complex 16391231 Component