Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 472
  • Symbol: ATM
  • Description: ATM serine/threonine kinase

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
472 GO:0000077 IDA involved_in DNA damage checkpoint signaling 30886146 Process
472 GO:0000425 IDA involved_in pexophagy 26344566 Process
472 GO:0006468 IDA involved_in protein phosphorylation 15448695,15916964 Process
472 GO:0006468 IMP involved_in protein phosphorylation 17694070,29203878 Process
472 GO:0006974 IDA involved_in DNA damage response 9733515,16213212 Process
472 GO:0006974 IMP acts_upstream_of_or_within DNA damage response 24550317 Process
472 GO:0006974 IMP involved_in DNA damage response 15790808,17875758 Process
472 GO:0007094 IMP involved_in mitotic spindle assembly checkpoint signaling 11943150 Process
472 GO:0007095 IMP involved_in mitotic G2 DNA damage checkpoint signaling 15149599 Process
472 GO:0010212 IDA involved_in response to ionizing radiation 9733515,11375976 Process
472 GO:0010506 IMP involved_in regulation of autophagy 23878245 Process
472 GO:0010628 IMP involved_in positive regulation of gene expression 28344092 Process
472 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 9733515,26323318 Process
472 GO:0030335 IMP involved_in positive regulation of cell migration 28344092 Process
472 GO:0030889 IMP involved_in negative regulation of B cell proliferation 17875758 Process
472 GO:0032210 IGI involved_in regulation of telomere maintenance via telomerase 26586433 Process
472 GO:0034614 IDA involved_in cellular response to reactive oxygen species 26344566 Process
472 GO:0036289 IMP acts_upstream_of_or_within peptidyl-serine autophosphorylation 24550317 Process
472 GO:0042770 IDA involved_in signal transduction in response to DNA damage 26774286 Process
472 GO:0042770 IMP involved_in signal transduction in response to DNA damage 27664052 Process
472 GO:0043065 IMP involved_in positive regulation of apoptotic process 17875758 Process
472 GO:0043517 IMP involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator 9733515 Process
472 GO:0046777 IDA involved_in protein autophosphorylation 9733515,15790808 Process
472 GO:0046777 IMP involved_in protein autophosphorylation 27664052 Process
472 GO:0051726 IMP involved_in regulation of cell cycle 15149599 Process
472 GO:0051972 IMP NOT involved_in regulation of telomerase activity 26586427 Process
472 GO:0071044 IDA involved_in histone mRNA catabolic process 16086026 Process
472 GO:0071480 IDA involved_in cellular response to gamma radiation 9925639,16213212 Process
472 GO:0071481 IDA involved_in cellular response to X-ray 26323318 Process
472 GO:0071500 IDA involved_in cellular response to nitrosative stress 23878245 Process
472 GO:0090399 IMP involved_in replicative senescence 15149599 Process
472 GO:0097694 IMP involved_in establishment of RNA localization to telomere 26586433 Process
472 GO:0097695 IMP involved_in establishment of protein-containing complex localization to telomere 26586433 Process
472 GO:1904262 IMP involved_in negative regulation of TORC1 signaling 23878245 Process
472 GO:1904354 IMP involved_in negative regulation of telomere capping 17694070 Process
472 GO:1904358 IMP involved_in positive regulation of telomere maintenance via telomere lengthening 17694070,26586427 Process
472 GO:1904884 IMP involved_in positive regulation of telomerase catalytic core complex assembly 26586433 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
472 GO:0000781 IDA colocalizes_with chromosome, telomeric region 15149599 Component
472 GO:0005634 IDA located_in nucleus 26323318 Component
472 GO:0005654 IDA located_in nucleoplasm Component
472 GO:0005730 IDA located_in nucleolus 27829214 Component
472 GO:0005782 IDA is_active_in peroxisomal matrix 26344566 Component
472 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
472 GO:1990391 IDA part_of DNA repair complex 24217620 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
472 GO:0004674 IDA enables protein serine/threonine kinase activity 9733515,11375976,20096447,26323318,26344566,26774286,30612738,..... Function
472 GO:0004677 IDA enables DNA-dependent protein kinase activity 15790808 Function
472 GO:0005515 IPI enables protein binding 9168117,9733515,11375976,12607005,15314656,16452482,17157788,1..... Function
472 GO:0016303 IMP enables 1-phosphatidylinositol-3-kinase activity 11375976 Function
472 GO:0042802 IPI enables identical protein binding 15790808 Function
472 GO:0044877 IDA enables protein-containing complex binding 15790808 Function