Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 4851
  • Symbol: NOTCH1
  • Description: notch receptor 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4851 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 17984306 Process
4851 GO:0001837 IMP involved_in epithelial to mesenchymal transition 17984306 Process
4851 GO:0003151 IMP involved_in outflow tract morphogenesis 18593716 Process
4851 GO:0003180 IMP involved_in aortic valve morphogenesis 16025100,17662764,18593716 Process
4851 GO:0003184 IMP involved_in pulmonary valve morphogenesis 16025100 Process
4851 GO:0003192 IMP involved_in mitral valve formation 16025100 Process
4851 GO:0007219 IDA involved_in Notch signaling pathway 11306509,23839946 Process
4851 GO:0007219 IMP involved_in Notch signaling pathway 19682396 Process
4851 GO:0007507 IMP involved_in heart development 21457232 Process
4851 GO:0008284 IDA involved_in positive regulation of cell population proliferation 17849174 Process
4851 GO:0008284 IMP involved_in positive regulation of cell population proliferation 20613903 Process
4851 GO:0008285 IDA involved_in negative regulation of cell population proliferation 20616313 Process
4851 GO:0010629 IDA involved_in negative regulation of gene expression 11306509 Process
4851 GO:0010812 IDA involved_in negative regulation of cell-substrate adhesion 16501043 Process
4851 GO:0035148 IMP involved_in tube formation 20616313 Process
4851 GO:0035924 IDA involved_in cellular response to vascular endothelial growth factor stimulus 20616313 Process
4851 GO:0045662 IMP involved_in negative regulation of myoblast differentiation 10713164 Process
4851 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 20616313,23839946 Process
4851 GO:0046579 IDA involved_in positive regulation of Ras protein signal transduction 11306509 Process
4851 GO:0060354 IMP involved_in negative regulation of cell adhesion molecule production 17984306 Process
4851 GO:0060412 IMP involved_in ventricular septum morphogenesis 16025100 Process
4851 GO:0061314 IMP involved_in Notch signaling involved in heart development 16025100,17662764 Process
4851 GO:0070374 IDA involved_in positive regulation of ERK1 and ERK2 cascade 11306509 Process
4851 GO:0071228 IDA involved_in cellular response to tumor cell 11306509 Process
4851 GO:0071372 IDA involved_in cellular response to follicle-stimulating hormone stimulus 20613903 Process
4851 GO:0090051 IDA involved_in negative regulation of cell migration involved in sprouting angiogenesis 20616313 Process
4851 GO:0097150 IEP involved_in neuronal stem cell population maintenance 19682396 Process
4851 GO:2000048 IMP involved_in negative regulation of cell-cell adhesion mediated by cadherin 17984306 Process
4851 GO:2000737 IMP involved_in negative regulation of stem cell differentiation 19682396 Process
4851 GO:2000811 IMP involved_in negative regulation of anoikis 17984306 Process
4851 GO:2001027 IDA involved_in negative regulation of endothelial cell chemotaxis 20616313 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4851 GO:0002193 IDA part_of MAML1-RBP-Jkappa- ICN1 complex 16510869 Component
4851 GO:0043235 IDA part_of receptor complex 23382219 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4851 GO:0003713 IDA enables transcription coactivator activity 23839946 Function
4851 GO:0004888 IDA enables transmembrane signaling receptor activity 23839946 Function
4851 GO:0005515 IPI enables protein binding 10713164,11006133,11101851,11390662,12370315,16319921,16510869..... Function
4851 GO:0042802 IPI enables identical protein binding 16738328 Function