Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 4864
  • Symbol: NPC1
  • Description: NPC intracellular cholesterol transporter 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4864 GO:0005515 IPI enables protein binding 16757520,19583955,20674861,25285302,26771495,27238017,28336668..... Function
4864 GO:0015485 IDA enables cholesterol binding 18772377 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4864 GO:0005635 IDA located_in nuclear envelope 12554680 Component
4864 GO:0005765 HDA located_in lysosomal membrane 17897319 Component
4864 GO:0005765 IDA located_in lysosomal membrane 9927649,28784760 Component
4864 GO:0005783 IDA located_in endoplasmic reticulum 12554680 Component
4864 GO:0005886 IDA located_in plasma membrane 10821832 Component
4864 GO:0016020 HDA located_in membrane 19946888 Component
4864 GO:0048471 IDA located_in perinuclear region of cytoplasm 12554680 Component
4864 GO:0070062 HDA located_in extracellular exosome 19056867 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4864 GO:0006486 IDA involved_in protein glycosylation 10821832 Process
4864 GO:0006914 IGI acts_upstream_of_or_within autophagy 19074461 Process
4864 GO:0030301 IDA involved_in cholesterol transport 18772377 Process
4864 GO:0031579 IMP involved_in membrane raft organization 23360953 Process
4864 GO:0032367 IMP involved_in intracellular cholesterol transport 9211849,27238017,28784760 Process
4864 GO:0033344 IDA involved_in cholesterol efflux 16141411 Process
4864 GO:0042632 IDA involved_in cholesterol homeostasis 12719428 Process
4864 GO:0042632 IMP involved_in cholesterol homeostasis 9211849,9927649,28784760 Process
4864 GO:0046718 IMP involved_in viral entry into host cell 21866101,21866103 Process
4864 GO:0090150 IDA involved_in establishment of protein localization to membrane 23360953 Process
4864 GO:1904262 IDA involved_in negative regulation of TORC1 signaling 28336668 Process