Gene Ontology

Gene Info

  • Species: Rat (Rattus norvegicus)
  • GeneID: 50557
  • Symbol: Pten
  • Description: phosphatase and tensin homolog

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
50557 GO:0005161 IDA enables platelet-derived growth factor receptor binding 14718524 Function
50557 GO:0005515 IPI enables protein binding 16474401,18082612,18550519,20628354,23940795 Function
50557 GO:0016314 IDA enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 17324556 Function
50557 GO:0016314 IMP enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 20628354 Function
50557 GO:0030165 IPI enables PDZ domain binding 20628354 Function
50557 GO:0035255 IDA enables ionotropic glutamate receptor binding 15102920 Function
50557 GO:1990782 IDA enables protein tyrosine kinase binding 22609523 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
50557 GO:0006470 IMP involved_in protein dephosphorylation 22609523 Process
50557 GO:0007584 IEP involved_in response to nutrient 17166883 Process
50557 GO:0007613 IMP involved_in memory 15317872 Process
50557 GO:0008285 IDA involved_in negative regulation of cell population proliferation 14656929 Process
50557 GO:0009410 IEP involved_in response to xenobiotic stimulus 16188065 Process
50557 GO:0009749 IEP involved_in response to glucose 16804083 Process
50557 GO:0010033 IEP involved_in response to organic substance 16807353 Process
50557 GO:0010035 IEP involved_in response to inorganic substance 17302912 Process
50557 GO:0010043 IEP involved_in response to zinc ion 18054565 Process
50557 GO:0010628 IMP involved_in positive regulation of gene expression 20578043 Process
50557 GO:0010666 IMP involved_in positive regulation of cardiac muscle cell apoptotic process 22609523,30783439 Process
50557 GO:0010977 IDA involved_in negative regulation of neuron projection development 28008308 Process
50557 GO:0014070 IEP involved_in response to organic cyclic compound 18095365 Process
50557 GO:0014823 IEP involved_in response to activity 23812090 Process
50557 GO:0031175 IDA involved_in neuron projection development 14990793 Process
50557 GO:0032355 IEP involved_in response to estradiol 15482376 Process
50557 GO:0032755 IMP involved_in positive regulation of interleukin-6 production 30783439 Process
50557 GO:0032760 IMP involved_in positive regulation of tumor necrosis factor production 30783439 Process
50557 GO:0032869 IDA involved_in cellular response to insulin stimulus 12700235 Process
50557 GO:0033198 IEP involved_in response to ATP 17132626 Process
50557 GO:0043065 IMP involved_in positive regulation of apoptotic process 16502258 Process
50557 GO:0043066 IMP involved_in negative regulation of apoptotic process 30783439 Process
50557 GO:0044320 IMP involved_in cellular response to leptin stimulus 24103758 Process
50557 GO:0045471 IEP involved_in response to ethanol 12939597 Process
50557 GO:0045666 IMP involved_in positive regulation of neuron differentiation 10662831 Process
50557 GO:0045786 IMP involved_in negative regulation of cell cycle 30783439 Process
50557 GO:0046685 IEP involved_in response to arsenic-containing substance 14713550 Process
50557 GO:0046856 IDA involved_in phosphatidylinositol dephosphorylation 17324556 Process
50557 GO:0046856 IMP involved_in phosphatidylinositol dephosphorylation 20628354 Process
50557 GO:0048008 IDA involved_in platelet-derived growth factor receptor signaling pathway 14718524 Process
50557 GO:0060044 IMP involved_in negative regulation of cardiac muscle cell proliferation 30783439 Process
50557 GO:0060292 IMP involved_in long-term synaptic depression 20628354 Process
50557 GO:0071361 IDA involved_in cellular response to ethanol 12700235 Process
50557 GO:0071545 IDA involved_in inositol phosphate catabolic process 18056380 Process
50557 GO:1900425 IMP involved_in negative regulation of defense response to bacterium 18056380 Process
50557 GO:1901017 IMP involved_in negative regulation of potassium ion transmembrane transporter activity 24103758 Process
50557 GO:1903860 IMP involved_in negative regulation of dendrite extension 23028614 Process
50557 GO:1905450 IMP involved_in negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis 18056380 Process
50557 GO:1990090 IEP involved_in cellular response to nerve growth factor stimulus 10662831 Process
50557 GO:1990314 IDA involved_in cellular response to insulin-like growth factor stimulus 12700235 Process
50557 GO:2000272 IMP involved_in negative regulation of signaling receptor activity 24044036 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
50557 GO:0043197 IDA located_in dendritic spine 20628354 Component
50557 GO:0045211 IDA located_in postsynaptic membrane 20628354 Component
50557 GO:0099524 IDA is_active_in postsynaptic cytosol 26780512 Component
50557 GO:0099524 IMP is_active_in postsynaptic cytosol 26780512 Component