Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5071
  • Symbol: PRKN
  • Description: parkin RBR E3 ubiquitin protein ligase

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5071 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 23985028 Process
5071 GO:0000209 IDA involved_in protein polyubiquitination 12150907,16227987,18541373,19880420 Process
5071 GO:0000209 IMP involved_in protein polyubiquitination 32047033 Process
5071 GO:0000422 IDA involved_in autophagy of mitochondrion 25621951 Process
5071 GO:0000422 IMP involved_in autophagy of mitochondrion 19029340,23933751,24896179 Process
5071 GO:0000423 IDA involved_in mitophagy 28017329 Process
5071 GO:0001933 IDA involved_in negative regulation of protein phosphorylation 17512523 Process
5071 GO:0006511 IDA involved_in ubiquitin-dependent protein catabolic process 12925569,17097639 Process
5071 GO:0006513 IDA involved_in protein monoubiquitination 20889974 Process
5071 GO:0006513 IMP involved_in protein monoubiquitination 24660806,32047033 Process
5071 GO:0010498 IMP involved_in proteasomal protein catabolic process 19725078 Process
5071 GO:0010506 IDA involved_in regulation of autophagy 20889974 Process
5071 GO:0010628 IMP involved_in positive regulation of gene expression 19725078 Process
5071 GO:0010629 IMP involved_in negative regulation of gene expression 19725078,22314364 Process
5071 GO:0010636 IMP involved_in positive regulation of mitochondrial fusion 23453807 Process
5071 GO:0010821 IDA involved_in regulation of mitochondrion organization 21113145 Process
5071 GO:0010821 IGI involved_in regulation of mitochondrion organization 19279012 Process
5071 GO:0010994 IMP involved_in free ubiquitin chain polymerization 24660806 Process
5071 GO:0016567 IDA involved_in protein ubiquitination 10973942,11439185,12628165,17314283 Process
5071 GO:0016567 IMP involved_in protein ubiquitination 23933751,26911690,29311685 Process
5071 GO:0030163 IMP involved_in protein catabolic process 21376232 Process
5071 GO:0031396 IGI involved_in regulation of protein ubiquitination 23212910 Process
5071 GO:0031396 IMP involved_in regulation of protein ubiquitination 20871098 Process
5071 GO:0031647 IMP involved_in regulation of protein stability 26911690 Process
5071 GO:0031648 IDA involved_in protein destabilization 19591802,29311685 Process
5071 GO:0032092 IMP involved_in positive regulation of protein binding 26911690 Process
5071 GO:0032232 IDA involved_in negative regulation of actin filament bundle assembly 17512523 Process
5071 GO:0033132 IDA acts_upstream_of_or_within negative regulation of glucokinase activity 24187134 Process
5071 GO:0034976 IMP involved_in response to endoplasmic reticulum stress 21113145 Process
5071 GO:0042053 IMP involved_in regulation of dopamine metabolic process 22314364 Process
5071 GO:0043123 IDA involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 17314283,19880420 Process
5071 GO:0043123 IMP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 23453807 Process
5071 GO:0043161 IDA involved_in proteasome-mediated ubiquitin-dependent protein catabolic process 11439185,21376232 Process
5071 GO:0043388 IDA involved_in positive regulation of DNA binding 17314283 Process
5071 GO:0043524 IDA involved_in negative regulation of neuron apoptotic process 12628165,22511790,23985028 Process
5071 GO:0044828 IDA involved_in negative regulation by host of viral genome replication 25244949 Process
5071 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 23453807 Process
5071 GO:0046676 IDA acts_upstream_of_or_within negative regulation of insulin secretion 24187134 Process
5071 GO:0050821 IMP involved_in protein stabilization 19229105 Process
5071 GO:0051582 IMP involved_in positive regulation of neurotransmitter uptake 22314364 Process
5071 GO:0051865 IDA involved_in protein autoubiquitination 12628165,15728840,16352719,17512523 Process
5071 GO:0061734 IDA involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 19029340 Process
5071 GO:0070534 IDA involved_in protein K63-linked ubiquitination 15728840,17314283,19880420,25621951 Process
5071 GO:0070842 IMP involved_in aggresome assembly 14645198 Process
5071 GO:0070936 IDA involved_in protein K48-linked ubiquitination 21376232,23858059 Process
5071 GO:0070979 IDA involved_in protein K11-linked ubiquitination 25621951 Process
5071 GO:0085020 IDA involved_in protein K6-linked ubiquitination 25621951 Process
5071 GO:0090090 IDA involved_in negative regulation of canonical Wnt signaling pathway 19591802 Process
5071 GO:0090201 IDA involved_in negative regulation of release of cytochrome c from mitochondria 19880420,23453807 Process
5071 GO:0097237 IMP involved_in cellular response to toxic substance 12628165 Process
5071 GO:0098779 IDA involved_in positive regulation of mitophagy in response to mitochondrial depolarization 20457763 Process
5071 GO:0098779 IMP involved_in positive regulation of mitophagy in response to mitochondrial depolarization 20871098,23212910 Process
5071 GO:0099074 IDA involved_in mitochondrion to lysosome transport 24446486 Process
5071 GO:1900407 IDA involved_in regulation of cellular response to oxidative stress 24446486 Process
5071 GO:1900407 IMP involved_in regulation of cellular response to oxidative stress 22314364 Process
5071 GO:1901215 IGI involved_in negative regulation of neuron death 21376232 Process
5071 GO:1901800 IGI involved_in positive regulation of proteasomal protein catabolic process 23858059 Process
5071 GO:1902236 IDA involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 11439185,12150907,23453807 Process
5071 GO:1902236 IMP involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 10973942,21113145 Process
5071 GO:1902254 IMP involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 23985028 Process
5071 GO:1902283 IMP involved_in negative regulation of primary amine oxidase activity 22314364 Process
5071 GO:1902530 IGI involved_in positive regulation of protein linear polyubiquitination 23453807 Process
5071 GO:1903265 IDA involved_in positive regulation of tumor necrosis factor-mediated signaling pathway 23453807 Process
5071 GO:1903377 IDA involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 17314283 Process
5071 GO:1903542 IMP involved_in negative regulation of exosomal secretion 26911690 Process
5071 GO:1903599 IDA involved_in positive regulation of autophagy of mitochondrion 26310625 Process
5071 GO:1904049 IMP involved_in negative regulation of spontaneous neurotransmitter secretion 22314364 Process
5071 GO:1905366 IMP involved_in negative regulation of intralumenal vesicle formation 26911690 Process
5071 GO:1905477 IMP involved_in positive regulation of protein localization to membrane 26911690 Process
5071 GO:2000377 IMP involved_in regulation of reactive oxygen species metabolic process 18541373 Process
5071 GO:2000378 IGI involved_in negative regulation of reactive oxygen species metabolic process 18541373 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5071 GO:0000151 IDA part_of ubiquitin ligase complex 12150907,17314283,23933751 Component
5071 GO:0005634 IDA located_in nucleus 23985028 Component
5071 GO:0005737 IDA located_in cytoplasm 17512523,19591802,21376232,23858059,23985028,25244949..... Component
5071 GO:0005739 IDA located_in mitochondrion 18957282,19229105,20889974,23933751,25244949 Component
5071 GO:0005739 IMP colocalizes_with mitochondrion 21508222 Component
5071 GO:0005739 IMP located_in mitochondrion 19029340 Component
5071 GO:0005783 IDA located_in endoplasmic reticulum 12150907 Component
5071 GO:0005794 IDA located_in Golgi apparatus 17097639 Component
5071 GO:0005829 IDA located_in cytosol 19029340,19229105,19880420,20889974,21753002,23933751,24751536..... Component
5071 GO:0005829 IMP located_in cytosol 21508222 Component
5071 GO:0016235 IDA located_in aggresome 14645198 Component
5071 GO:0016607 IDA located_in nuclear speck Component
5071 GO:0019005 IDA NOT part_of SCF ubiquitin ligase complex 12628165 Component
5071 GO:0043005 IDA located_in neuron projection 12925569 Component
5071 GO:0048471 IDA located_in perinuclear region of cytoplasm 17097639 Component
5071 GO:0099073 IDA colocalizes_with mitochondrion-derived vesicle 24446486 Component
5071 GO:1990452 IPI part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex 12628165 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5071 GO:0001664 IPI enables G protein-coupled receptor binding 12150907 Function
5071 GO:0003714 IDA enables transcription corepressor activity 23985028 Function
5071 GO:0003779 IPI enables actin binding 21753002 Function
5071 GO:0004842 EXP enables ubiquitin-protein transferase activity 31358971 Function
5071 GO:0004842 IDA enables ubiquitin-protein transferase activity 11078524,15728840,17097639,18541373,20889974,21376232,24784582..... Function
5071 GO:0005515 IPI enables protein binding 10888878,11078524,11439185,11590439,12364339,12628165,12925569..... Function
5071 GO:0008013 IDA enables beta-catenin binding 19591802 Function
5071 GO:0015631 IPI enables tubulin binding 21753002 Function
5071 GO:0019899 IPI enables enzyme binding 19725078 Function
5071 GO:0019900 IPI enables kinase binding 17512523,19229105,19880420,24187134 Function
5071 GO:0019901 IPI enables protein kinase binding 20798600 Function
5071 GO:0030165 IPI enables PDZ domain binding 17512523 Function
5071 GO:0030544 IPI enables Hsp70 protein binding 12150907,21753002 Function
5071 GO:0031072 IPI enables heat shock protein binding 12150907 Function
5071 GO:0031624 IDA enables ubiquitin conjugating enzyme binding 10973942 Function
5071 GO:0031624 IPI enables ubiquitin conjugating enzyme binding 11439185,12628165 Function
5071 GO:0031625 IMP enables ubiquitin protein ligase binding 24751536 Function
5071 GO:0031625 IPI enables ubiquitin protein ligase binding 12150907,21532592,23453807 Function
5071 GO:0042802 IPI enables identical protein binding 21694720 Function
5071 GO:0042826 IPI enables histone deacetylase binding 21753002 Function
5071 GO:0043130 IDA enables ubiquitin binding 24784582 Function
5071 GO:0043274 IPI enables phospholipase binding 19725078 Function
5071 GO:0044877 IPI enables protein-containing complex binding 23453807 Function
5071 GO:0051087 IPI enables protein-folding chaperone binding 15603737,19725078,21753002 Function
5071 GO:0061630 IDA enables ubiquitin protein ligase activity 10973942,11439185,12150907,12628165,12925569,16227987,19229105..... Function
5071 GO:0061630 IMP enables ubiquitin protein ligase activity 32047033 Function
5071 GO:0097602 IDA enables cullin family protein binding 12628165 Function
5071 GO:1990381 IPI enables ubiquitin-specific protease binding 24063750 Function
5071 GO:1990444 IPI enables F-box domain binding 12628165 Function